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General Information
Symbol
Dmel\Sirt1ex10
Species
D. melanogaster
Name
FlyBase ID
FBal0137348
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Excision of the P{PZ} element that results in an 8bp duplication and a 30bp insertion that disrupts the Sir2 start site.

Insertion components
P{?PZ}Sirt1ex10
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The position effect variegation of the w gene seen in P{lacW}50C.x6, In(1)wm4 and P{hsp26-pt-T}39C-72 is suppressed in Sir2ex10 heterozygotes. The position effect variegation of the w gene seen in P{hsp26-pt-T}39C-5 and P{hsp26-pt-T}39C-55 is not suppressed in Sir2ex10 heterozygotes. There is a marked decrease from the expected number of male progeny in the progeny of a cross between heterozygous males and females.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Embryos derived from Sir2ex10/+ ; RpII140wimp/+ females (mated to wild-type males) die and show anterior-posterior patterning defects, including loss of segments and pairwise denticle band fusions.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Separable from: a second site recessive lethal mutation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Sir2ex10
Sirt1ex10
Name Synonyms
Secondary FlyBase IDs
    References (2)