FlyBase Allele Report: Dmel\Sirt1[ex10]

General Information

Symbol

Dmel\Sirt1^ex10

Species

D. melanogaster

Name

FlyBase ID

FBal0137348

Feature type

allele

Associated gene

Dmel\Sirt1

Associated Insertion(s)

P{?PZ}Sirt1^ex10

Carried in Construct

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Rosenberg and Parkhurst, 2002)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Sirt1^05327a

(Rosenberg and Parkhurst, 2002)

Cytology

Nature of the lesion

Statement

Reference

Excision of the P{PZ} element that results in an 8bp duplication and a 30bp insertion that disrupts the Sir2 start site.

(Rosenberg and Parkhurst, 2002)

Insertion components

P{?PZ}Sirt1^ex10

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The position effect variegation of the w gene seen in P{lacW}50C.x6, In(1)w^m4 and P{hsp26-pt-T}39C-72 is suppressed in Sir2^ex10 heterozygotes. The position effect variegation of the w gene seen in P{hsp26-pt-T}39C-5 and P{hsp26-pt-T}39C-55 is not suppressed in Sir2^ex10 heterozygotes. There is a marked decrease from the expected number of male progeny in the progeny of a cross between heterozygous males and females.

(Rosenberg and Parkhurst, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Sirt1^ex10, Sxl[+]/Sxl^f1 has viable phenotype

(Astrom et al., 2003)

Sirt1^ex10, Sxl^f1 has viable phenotype

(Astrom et al., 2003)

Polr2B^wimp, Sirt1^ex10 has lethal | dominant | embryonic stage | maternal effect phenotype

(Rosenberg and Parkhurst, 2002)

RpII140[+]/Polr2B^wimp, Sirt1^ex10 has lethal | dominant | embryonic stage | maternal effect phenotype

(Rosenberg and Parkhurst, 2002)

Phenotype Manifest In

Other

Statement

Reference

Polr2B^wimp, Sirt1^ex10 has denticle belt phenotype

(Rosenberg and Parkhurst, 2002)

Polr2B^wimp, Sirt1^ex10 has embryonic segment phenotype

(Rosenberg and Parkhurst, 2002)

RpII140[+]/Polr2B^wimp, Sirt1^ex10 has denticle belt phenotype

(Rosenberg and Parkhurst, 2002)

RpII140[+]/Polr2B^wimp, Sirt1^ex10 has embryonic segment phenotype

(Rosenberg and Parkhurst, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos derived from Sir2^ex10/+ ; RpII140^wimp/+ females (mated to wild-type males) die and show anterior-posterior patterning defects, including loss of segments and pairwise denticle band fusions.

(Rosenberg and Parkhurst, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: a second site recessive lethal mutation.

(Astrom et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sir2^ex10

Sirt1^ex10

dsir2^ex10

(Astrom et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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