FlyBase Allele Report: Scer\GAL4[Ilp2.PR]

Drives larval expression in a small cluster of insulin-producing cells in each brain lobe; processes from these neurons extend to the heart. Drives adult expression in cells of the pars intercerebralis.

(FlyBase Curators, 2017)

ScerGAL4^Ilp2.PR-driven expression does not overlap with Ddc expression in the pupal or adult brain or larval ventral nerve cord.

(Agrawal et al., 2010)

ScerGAL4^Ilp2.PR is expressed in insulin-like producing cells.

(Agrawal et al., 2010)

ScerGAL4^Ilp2.PR drives expression in cells of the pars intercerebralis. Most of these cells co-express PICK1 protein.

(Jansen et al., 2009)

Larval expression is observed in a cluster of seven neurosecretory cells in each brain lobe.

(Colombani et al., 2003)

Larval expression is observed in a small cluster of insulin-producing cells in each brain lobe. Processes from these neurons extend to the heart.

(Rulifson et al., 2002)

Larval expression is observed in a small cluster of insulin-producing cells in each brain lobe.

(Rulifson et al., 2002)

Marker for

insulin secreting cell of pars intercerebralis

(Meiselman et al., 2022)

neurosecretory neuron

(Rulifson et al., 2002, Rulifson et al., 2002)

Reflects expression of

Ilp2

(Meiselman et al., 2022, Buhler et al., 2018, Davis et al., 2014, Agrawal et al., 2010, Crocker et al., 2010, Jansen et al., 2009, Colombani et al., 2003, Rulifson et al., 2002, Rulifson et al., 2002)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | male limited, with 5-HT1A^JF01852

(Williams et al., 2014)

abnormal behavior | male limited, with Bhal\NaChBac^UAS.EGFP

(Davis et al., 2014)

abnormal behavior | male limited, with Dsk^UAS.cCa

(Williams et al., 2014)

abnormal behavior | male limited, with Ktl^JF01869

(Williams et al., 2014)

abnormal behavior | male limited, with tll^JF02545

(Davis et al., 2014)

abnormal body size, with foxo^UAS.Tag:FLAG

(Nielsen et al., 2008)

abnormal body size, with Itpr^UAS.cVa, Itpr^sv35/Itpr^ug3

(Agrawal et al., 2009)

abnormal circadian rhythm | oogenesis, with AstC-R1^GD659

(Zhang et al., 2021)

abnormal circadian rhythm | oogenesis, with AstC-R2^GD17055

(Zhang et al., 2021)

abnormal courtship behavior | male limited, with 5-HT1A^JF01852

(Williams et al., 2014)

abnormal courtship behavior | male limited, with Ktl^JF01869

(Williams et al., 2014)

abnormal developmental rate, with Erk7^{UAS.Tag:V5,Tag:polyHis}

(Hasygar and Hietakangas, 2014)

abnormal developmental rate, with p53^UAS.Ex

(Hasygar and Hietakangas, 2014)

abnormal developmental rate, with RIOK2^KK101850

(Hasygar and Hietakangas, 2014)

abnormal developmental rate, with RIOK2^NIG.11859R

(Hasygar and Hietakangas, 2014)

abnormal developmental rate, with rpr^UAS.C

(Wessells et al., 2004, Rulifson et al., 2002)

abnormal feeding behavior | male limited, with Dsk^JF01908

(Williams et al., 2014)

abnormal feeding behavior | third instar larval stage, with flz^GD1886

(Pathak et al., 2021)

abnormal locomotor behavior | adult stage, with InR^K1409A.UAS

(Yamaguchi et al., 2022)

abnormal locomotor behavior | male limited, with Dsk^UAS.cCa

(Williams et al., 2014)

abnormal locomotor behavior | male limited, with Ktl^JF01869

(Williams et al., 2014)

abnormal memory, with pain^RNAi.UAS

(Sakai et al., 2012)

abnormal neuroanatomy | adult stage, with Nrg^180.I.UAS

(Clements et al., 2021)

abnormal neuroanatomy | adult stage, with Nrg^GD82

(Clements et al., 2021)

abnormal neuroanatomy | adult stage, with PlexA^HM05221

(Clements et al., 2021)

abnormal neuroanatomy | adult stage, with Sema1a^HMS01307

(Clements et al., 2021)

abnormal neurophysiology, with Itpr^NIG.1063R

(Agrawal et al., 2010)

abnormal neurophysiology, with Mmus\Ucp1^UAS.cFa

(Fridell et al., 2009)

abnormal neurophysiology, with Slob^UAS.cSa

(Shahidullah et al., 2009)

abnormal oxidative stress response | adult stage, with Hsap\UCP2^UAS.cFa

(Fridell et al., 2009)

abnormal oxidative stress response | adult stage, with Mmus\Ucp1^UAS.cFa

(Fridell et al., 2009)

abnormal oxidative stress response | adult stage, with Nrg^GD82

(Clements et al., 2021)

abnormal oxidative stress response | male limited, with Cbl^GD12111

(Yu et al., 2012)

abnormal sleep, with Bhal\NaChBac^UAS.EGFP

(Crocker et al., 2010)

abnormal sleep, with Pka-R1^{BDK.UAS.Tag:HA}

(Crocker et al., 2010)

abnormal sleep, with Sh^{EKO.UAS.GFP(GL)}

(Crocker et al., 2010)

abnormal sleep | male limited, with Ktl^JF01869

(Williams et al., 2014)

abnormal starvation stress response, with Aps^KK108331

(Williams et al., 2015)

abnormal starvation stress response, with Tmem18^GD4536

(Wiemerslage et al., 2016)

abnormal starvation stress response | adult stage, with flz^GD1886

(Pathak et al., 2021)

abnormal starvation stress response | adult stage, with Hsap\UCP2^UAS.cFa

(Fridell et al., 2009)

abnormal starvation stress response | adult stage, with Mmus\Ucp1^UAS.cFa

(Fridell et al., 2009)

abnormal starvation stress response | adult stage, with NPFR^JF01959

(Yoshinari et al., 2021)

abnormal starvation stress response | adult stage, with Nrg^GD82

(Clements et al., 2021)

abnormal starvation stress response | adult stage, with PlexA^HM05221

(Clements et al., 2021)

abnormal starvation stress response | adult stage, with promL^GD2271

(Ryu et al., 2019)

abnormal starvation stress response | adult stage | nutrition conditional, with Lkr^HMC06205

(Zandawala et al., 2018)

abnormal starvation stress response | adult stage | nutrition conditional, with Lkr^JF01956

(Zandawala et al., 2018)

abnormal stress response, with bsk^GD10555

(Karpac et al., 2009)

abnormal stress response, with bsk^K53R.UAS

(Karpac et al., 2009)

abnormal stress response, with Ilp2^UAS.cBa

(Karpac et al., 2009)

chemical resistant, with Egfr^UAS.cBa

(Corl et al., 2009)

chemical resistant, with Ilp5^UAS.cIa

(McClure et al., 2011)

chemical resistant, with Ilp6^UAS.cIa

(McClure et al., 2011)

chemical resistant | adult stage, with Hmgcr^RNAi.UAS.cUa

(Williams et al., 2022)

chemical resistant | larval stage, with Ilp2^UAS.cBa

(McClure et al., 2011)

chemical sensitive, with Egfr^DN.UAS

(Corl et al., 2009)

decreased body size, with Hsap\IDE^UAS.cTa

(Tsuda et al., 2010)

decreased body size, with Hsap\INS^{LB15YB16delinsH.UAS}

(Yamazoe et al., 2021)

decreased body size, with Ide^UAS.cHa

(Hyun and Hashimoto, 2011)

decreased body size, with Ide^UAS.cTa

(Tsuda et al., 2010)

decreased body size, with Ilp1^GD2398

(Lee et al., 2008)

decreased body size, with Ilp2^GD15756

(Lee et al., 2008)

decreased body size, with rpr^UAS.C

(Wessells et al., 2004, Rulifson et al., 2002)

decreased body size, with sNPF-R^DN.UAS

(Lee et al., 2008)

decreased body size | adult stage, with Adck1^KK102382

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Adck1^NIG.3608R

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with btl^KK100331

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with btl^NIG.32134R

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Cdk12^GD9926

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with CG3527^KK102664

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with CG5033^KK102696

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with CG7006^KK100710

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with CG7246^GD10658

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with CG8939^KK100755

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with CG11583^GD10836

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with dbe^KK102268

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Drak^GL00087

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Drak^KK101989

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Dsor1^GD9123

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Dsor1^KK102276

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with flz^GD1886

(Pathak et al., 2021)

decreased body size | adult stage, with flz^KK105169

(Pathak et al., 2021)

decreased body size | adult stage, with foxo^UAS.cPa

(Wang et al., 2005)

decreased body size | adult stage, with hep^Act.UAS

(Wang et al., 2005)

decreased body size | adult stage, with Hmgcr^RNAi.UAS.cUa

(Williams et al., 2022)

decreased body size | adult stage, with mTor^HMS00904

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with mTor^HMS01114

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Myc^KK103869

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Ns1^KK102000

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Ns2^KK100382

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Ns3^KK100380

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Pdk1^GD7480

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Pdk1^KK108363

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Pkc98E^GD9685

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Pkc98E^KK107658

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Pkc98E^NIG.1954R

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with raptor^JF01087

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with raptor^JF01088

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Rbm13^KK101004

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RIOK1^GD8541

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RIOK1^KK100810

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RIOK2^KK101850

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RIOK2^NIG.11859R

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RpL22^HMS00143

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RpL22^KK109432

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RpL24-like^KK107783

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with RpL35A^KK108710

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Rs1^KK102837

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with sxc^GD6968

(Sekine et al., 2010)

decreased body size | adult stage, with Tlk^KK108036

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Tlk^NIG.2829R

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with trc^GD13993

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with trc^KK109419

(Hasygar and Hietakangas, 2014)

decreased body size | adult stage, with Tsr1^GD12206

(Hasygar and Hietakangas, 2014)

decreased body size | male limited, with Egfr^DN.UAS.cBa

(Yu et al., 2012)

decreased body size | nutrition conditional, with JhI-21^KK112996

(Ziegler et al., 2018)

decreased body size | P-stage, with Erk7^{UAS.Tag:V5,Tag:polyHis}

(Hasygar et al., 2021)

decreased body size | pupal stage, with Erk7^{UAS.Tag:V5,Tag:polyHis}

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with flz^GD1886

(Pathak et al., 2021)

decreased body size | pupal stage, with flz^KK105169

(Pathak et al., 2021)

decreased body size | pupal stage, with grnd^intra.UAS

(de Vreede et al., 2018)

decreased body size | pupal stage, with grnd^{N63A.UAS.Tag:V5}

(de Vreede et al., 2018)

decreased body size | pupal stage, with p53^UAS.Ex

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with RIOK1^GD8541

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with RIOK1^KK100810

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with RIOK2^KK101850

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with RIOK2^NIG.11859R

(Hasygar and Hietakangas, 2014)

decreased body size | pupal stage, with slif^UY681

(Pathak et al., 2021)

decreased body size | third instar larval stage, with sxc^GD6968

(Sekine et al., 2010)

decreased body weight | adult stage, with Hmgcr^RNAi.UAS.cUa

(Williams et al., 2022)

decreased cell number, with mir-9a^{UAS.cSa.DsRed2}

(Suh et al., 2015)

decreased cell number, with rpr^UAS.C

(Rulifson et al., 2002)

decreased cell size, with mir-9a^{UAS.cSa.DsRed2}

(Suh et al., 2015)

decreased cell size, with rpr^UAS.C

(Rulifson et al., 2002)

decreased cell size | third instar larval stage, with flz^GD1886

(Pathak et al., 2021)

decreased fecundity | female, with Ide^UAS.cHa

(Hyun and Hashimoto, 2011)

decreased sleep | adult stage, with InR^K1409A.UAS

(Yamaguchi et al., 2022)

increased body size, with Ide^RNAi.513.UAS

(Hyun and Hashimoto, 2011)

increased body size, with mir-9a^{sponge.UAS.mCherry}

(Suh et al., 2015)

increased body size, with sNPF-R^UAS.cLa

(Lee et al., 2008)

increased body size | adult stage, with Hsap\INS^UAS.cYa

(Yamazoe et al., 2021)

increased body size | adult stage, with Oga^GD10644

(Sekine et al., 2010)

increased body size | adult stage, with sxc^UAS.Tag:MYC

(Sekine et al., 2010)

increased body size | male limited, with Cbl^GD12111

(Yu et al., 2012)

increased body size | third instar larval stage, with Oga^GD10644

(Sekine et al., 2010)

increased body size | third instar larval stage, with sxc^UAS.Tag:MYC

(Sekine et al., 2010)

increased body weight, with Ilp2^UAS.cRa

(Ren et al., 2018)

increased body weight, with TBC1d7^125Q.UAS

(Ren et al., 2018)

increased body weight, with TBC1d7^{RNAi.UAS.TH04339}

(Ren et al., 2018)

increased body weight | adult stage, with dcma^GD15126

(Wilson et al., 2020)

increased cell number, with mir-9a^{sponge.UAS.mCherry}

(Suh et al., 2015)

increased cell size, with mir-9a^{sponge.UAS.mCherry}

(Suh et al., 2015)

increased fecundity | female, with AstC-R1^GD659

(Zhang et al., 2021)

increased fecundity | female, with AstC-R1^JF02656

(Zhang et al., 2021)

increased fecundity | female, with AstC-R2^GD17055

(Zhang et al., 2021)

increased fecundity | female, with AstC-R2^JF01960

(Zhang et al., 2021)

increased fecundity | female, with Ide^RNAi.513.UAS

(Hyun and Hashimoto, 2011)

increased fecundity | female, with TrpA1^UAS.(B).cKa

(Zhang et al., 2021)

increased rate of feeding behavior | adult stage, with Hmgcr^KK101807

(Williams et al., 2022)

increased rate of feeding behavior | adult stage, with Hmgcr^NIG.10367R

(Williams et al., 2022)

increased rate of feeding behavior | adult stage, with NPFR^JF01959

(Yoshinari et al., 2021)

increased size | adult stage, with Hsap\INS^C96Y.UAS.cYa

(Yamazoe et al., 2021)

increased size | adult stage, with Hsap\INS^UAS.cYa

(Yamazoe et al., 2021)

increased sleep, with mir-276a^UAS.pLUC

(Zhang et al., 2021)

lethal, with Rcom\RT^A.UAS

(Lien et al., 2020)

long lived, with dcma^GD15126

(Wilson et al., 2020)

long lived, with Hsap\UCP2^UAS.cFa

(Fridell et al., 2009)

long lived, with Mmus\Ucp1^UAS.cFa

(Fridell et al., 2009)

long lived, with PGRP-LE^HMC05031

(Xu et al., 2023)

long lived, with promL^GD2271

(Ryu et al., 2019)

long lived | female limited, with Hsap\IDE^UAS.cHa

(Hyun and Hashimoto, 2011)

long lived | female limited, with Ide^UAS.cHa

(Hyun and Hashimoto, 2011)

long lived | nutrition conditional, with AstA-R2^GD339

(Hentze et al., 2015)

partially lethal - majority die, with dcma^GD15126

(Wilson et al., 2020)

short lived, with Ilp2^UAS.cRa

(Ren et al., 2018)

short lived, with TBC1d7^{RNAi.UAS.TH04339}

(Ren et al., 2018)

short lived | female limited, with Ide^RNAi.513.UAS

(Hyun and Hashimoto, 2011)

short lived | male limited, with Cbl^GD12111

(Yu et al., 2012)

viable, with rpr^UAS.C

(Wessells et al., 2004)

visible, with mir-9a^{sponge.UAS.mCherry}

(Suh et al., 2015)

visible, with mir-9a^{UAS.cSa.DsRed2}

(Suh et al., 2015)

visible, with mir-9b^{UAS.cluster.cSa.DsRed2}

(Suh et al., 2015)

visible, with mir-79^{UAS.cluster.cSa.DsRed2}

(Suh et al., 2015)

visible, with mir-306^{UAS.cluster.cSa.DsRed2}

(Suh et al., 2015)

Phenotype Manifest In

adult insulin secreting cell of pars intercerebralis, with NPFR^JF01959

(Yoshinari et al., 2021)

adult insulin secreting cell of pars intercerebralis, with Nrg^180.I.UAS

(Clements et al., 2021)

adult insulin secreting cell of pars intercerebralis, with Nrg^GD82

(Clements et al., 2021)

adult insulin secreting cell of pars intercerebralis, with PlexA^HM05221

(Clements et al., 2021)

adult insulin secreting cell of pars intercerebralis, with Sema1a^HMS01307

(Clements et al., 2021)

adult pars intercerebralis, with Slob^UAS.cSa

(Shahidullah et al., 2009)

anterior crossvein, with mir-9a^{UAS.cSa.DsRed2}

(Suh et al., 2015)

anterior crossvein, with mir-9b^{UAS.cluster.cSa.DsRed2}

(Suh et al., 2015)

anterior crossvein, with mir-79^{UAS.cluster.cSa.DsRed2}

(Suh et al., 2015)

anterior crossvein, with mir-306^{UAS.cluster.cSa.DsRed2}

(Suh et al., 2015)

egg chamber | decreased number | oogenesis, with AstC-R1^GD659

(Zhang et al., 2021)

egg chamber | decreased number | oogenesis, with AstC-R2^GD17055

(Zhang et al., 2021)

follicle cell, with rpr^UAS.C

(LaFever and Drummond-Barbosa, 2005)

hemolymph, with Ide^RNAi.513.UAS

(Hyun and Hashimoto, 2011)

neurite | adult stage, with Nrg^180.I.UAS

(Clements et al., 2021)

neurite | adult stage | ectopic, with Nrg^GD82

(Clements et al., 2021)

neurite | adult stage | ectopic, with PlexA^HM05221

(Clements et al., 2021)

neurite | adult stage | ectopic, with Sema1a^HMS01307

(Clements et al., 2021)

polar primary spermatocyte, with rpr^UAS.C

(Ueishi et al., 2009)

terminal tracheal cell | third instar larval stage, with flz^GD1886

(Pathak et al., 2021)

tracheal branch | third instar larval stage, with flz^GD1886

(Pathak et al., 2021)

wing, with Eps-15^UAS.cLa

(Li et al., 2015)

wing, with hppy^UAS.cZa

(Zheng et al., 2015)

wing, with Hsap\INS^C96Y.UAS.cYa

(Yamazoe et al., 2021)

wing, with Hsap\INS^UAS.cYa

(Yamazoe et al., 2021)

wing, with mir-9a^{sponge.UAS.mCherry}

(Suh et al., 2015)

wing, with mir-9a^{UAS.cSa.DsRed2}

(Suh et al., 2015)

wing, with rpr^UAS.C

(Rulifson et al., 2002)

Detailed Description

Statement

Reference

Activation of Scer\GAL4^Ilp2.PR-positive neurons (by the expression of TrpA1^UAS.(B).cKa under the control of Scer\GAL4^Ilp2.PR) leads to increased female fecundity.

(Zhang et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^Ilp2.PR, dcma^GD15126 has long lived phenotype, suppressible by Ilp2^UAS.cBa, Scer\GAL4^Ilp2.PR

(Wilson et al., 2020)

Scer\GAL4^Ilp2.PR, mir-9a^{UAS.cSa.DsRed2} has visible phenotype, suppressible by Scer\GAL4^Ilp2.PR/sNPF-R^UAS.cSa

(Suh et al., 2015)

Scer\GAL4^Ilp2.PR, mir-9a^{sponge.UAS.mCherry} has visible phenotype, suppressible by sNPF-R[+]/sNPF-R^MI00427

(Suh et al., 2015)

RIOK1^KK100810, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^JF02513, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK1^KK100810, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^KK113065, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK1^GD8541, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^JF02513, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK1^GD8541, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^KK113065, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^KK101850, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^JF02513, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^KK101850, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^KK113065, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^KK101850, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by Erk7^KK102574, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^KK101850, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by Erk7^HMS00222, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^JF02513, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by p53^KK113065, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by Erk7^KK102574, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR has decreased body size | pupal stage phenotype, suppressible | partially by Erk7^HMS00222, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Scer\GAL4^Ilp2.PR, p53^UAS.Ex has decreased body size | pupal stage phenotype, suppressible | partially by Erk7^KK102574, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Scer\GAL4^Ilp2.PR, p53^UAS.Ex has abnormal developmental rate phenotype, suppressible | partially by Erk7^KK102574, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Scer\GAL4^Ilp2.PR, p53^UAS.Ex has decreased body size | pupal stage phenotype, suppressible | partially by Erk7^HMS00222, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Scer\GAL4^Ilp2.PR, p53^UAS.Ex has abnormal developmental rate phenotype, suppressible | partially by Erk7^HMS00222, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Cbl^GD12111, Scer\GAL4^Ilp2.PR has increased body size | male limited phenotype, suppressible by Egfr^DN.UAS.cBa, Scer\GAL4^Ilp2.PR

(Yu et al., 2012)

Scer\GAL4^Ilp2.PR, bsk^K53R.UAS has abnormal stress response phenotype, suppressible by Ilp2^GD15756, Scer\GAL4^Ilp2.PR

(Karpac et al., 2009)

Scer\GAL4^Ilp2.PR, foxo^UAS.Tag:FLAG has abnormal body size phenotype, suppressible by 14-3-3ε^UAS.cCa, Scer\GAL4^Ilp2.PR

(Nielsen et al., 2008)

Scer\GAL4^Ilp2.PR, hep^Act.UAS has decreased body size | adult stage phenotype, suppressible | partially by foxo²⁵/foxo[+]

(Wang et al., 2005)

Scer\GAL4^Ilp2.PR, rpr^UAS.C has decreased body size phenotype, suppressible by Ilp2^hs.PR

(Rulifson et al., 2002)

Scer\GAL4^Ilp2.PR, rpr^UAS.C has abnormal developmental rate phenotype, suppressible | heat sensitive by Ilp2^hs.PR

(Rulifson et al., 2002)

Scer\GAL4^Ilp2.PR, rpr^UAS.C has decreased cell number phenotype, suppressible | heat sensitive by Ilp2^hs.PR

(Rulifson et al., 2002)

Scer\GAL4^Ilp2.PR, rpr^UAS.C has decreased cell size phenotype, suppressible | heat sensitive by Ilp2^hs.PR

(Rulifson et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^Ilp2.PR, flz^GD1886 has decreased body size | adult stage phenotype, non-suppressible by Ilp2^UAS.cUa, Scer\GAL4^Ilp2.PR

(Pathak et al., 2021)

Ilp2^GD15756, Scer\GAL4^Ilp2.PR has decreased body size phenotype, non-suppressible by sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

Ilp1^GD2398, Scer\GAL4^Ilp2.PR has decreased body size phenotype, non-suppressible by sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

Suppressor of

Statement

Reference

Scer\GAL4^Ilp2.PR/Ilp2^UAS.cBa is a suppressor of abnormal starvation stress response | semidominant | adult stage phenotype of mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^Ilp2.PR/Ilp2^UAS.cBa is a suppressor of abnormal starvation stress response | semidominant | adult stage phenotype of mir-137^KO

(Saedi et al., 2024)

CRMP^TH02545.N/Scer\GAL4^Ilp2.PR is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Scer\GAL4^Ilp2.PR/CRMP^KK108924 is a suppressor | partially of abnormal circadian rhythm | adult stage phenotype of Fmr1^Δ50M/Fmr1³

(Zhao et al., 2021)

Ilp2^UAS.cBa, Scer\GAL4^Ilp2.PR is a suppressor of long lived phenotype of Scer\GAL4^Ilp2.PR, dcma^GD15126

(Wilson et al., 2020)

Scer\GAL4^Ilp2.PR/Hsap\TBC1D7^UAS.cRa is a suppressor of abnormal size | cell non-autonomous | adult stage phenotype of TBC1d7^KO

(Ren et al., 2018)

Scer\GAL4^Ilp2.PR/Hsap\TBC1D7^UAS.cRa is a suppressor | partially of abnormal size | adult stage phenotype of TBC1d7^KO

(Ren et al., 2018)

Scer\GAL4^Ilp2.PR/sNPF-R^UAS.cSa is a suppressor of visible phenotype of Scer\GAL4^Ilp2.PR, mir-9a^{UAS.cSa.DsRed2}

(Suh et al., 2015)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK1^KK100810, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^KK113065, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK1^KK100810, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK1^GD8541, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^KK113065, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK1^GD8541, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^KK101850, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^KK113065, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^KK101850, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Erk7^KK102574, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^KK101850, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Erk7^HMS00222, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^KK101850, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^JF02513, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

p53^KK113065, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Erk7^KK102574, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Erk7^HMS00222, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of RIOK2^NIG.11859R, Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

Erk7^KK102574, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of Scer\GAL4^Ilp2.PR, p53^UAS.Ex

(Hasygar and Hietakangas, 2014)

Erk7^KK102574, Scer\GAL4^Ilp2.PR is a suppressor | partially of abnormal developmental rate phenotype of Scer\GAL4^Ilp2.PR, p53^UAS.Ex

(Hasygar and Hietakangas, 2014)

Erk7^HMS00222, Scer\GAL4^Ilp2.PR is a suppressor | partially of decreased body size | pupal stage phenotype of Scer\GAL4^Ilp2.PR, p53^UAS.Ex

(Hasygar and Hietakangas, 2014)

Erk7^HMS00222, Scer\GAL4^Ilp2.PR is a suppressor | partially of abnormal developmental rate phenotype of Scer\GAL4^Ilp2.PR, p53^UAS.Ex

(Hasygar and Hietakangas, 2014)

Scer\GAL4^Ilp2.PR/Ilp2^UAS.cBa is a suppressor of abnormal starvation stress response phenotype of Itpr^ug3/Itpr^ka1091

(Subramanian et al., 2013)

Scer\GAL4^Ilp2.PR/Ilp2^UAS.cBa is a suppressor of increased body size phenotype of Itpr^ug3/Itpr^ka1091

(Subramanian et al., 2013)

Scer\GAL4^Ilp2.PR/Ilp2^UAS.cBa is a suppressor of abnormal feeding behavior phenotype of Itpr^ug3/Itpr^ka1091

(Subramanian et al., 2013)

Scer\GAL4^Ilp2.PR/bsk^K53R.UAS is a suppressor of abnormal starvation stress response phenotype of Itpr^ug3/Itpr^ka1091

(Subramanian et al., 2013)

Egfr^DN.UAS.cBa, Scer\GAL4^Ilp2.PR is a suppressor of increased body size | male limited phenotype of Cbl^GD12111, Scer\GAL4^Ilp2.PR

(Yu et al., 2012)

Stim^UAS.cAa, Scer\GAL4^Ilp2.PR, Orai^UAS.cZa is a suppressor of visible phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa, Scer\GAL4^Ilp2.PR, Orai^UAS.cZa is a suppressor of abnormal neurophysiology phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa/Scer\GAL4^Ilp2.PR is a suppressor of visible phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa/Scer\GAL4^Ilp2.PR is a suppressor of abnormal neurophysiology phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa, Scer\GAL4^Ilp2.PR, Orai^UAS.cZa is a suppressor of abnormal flight phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa/Scer\GAL4^Ilp2.PR is a suppressor of abnormal flight phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Ilp2^GD15756, Scer\GAL4^Ilp2.PR is a suppressor of abnormal stress response phenotype of Scer\GAL4^Ilp2.PR, bsk^K53R.UAS

(Karpac et al., 2009)

14-3-3ε^UAS.cCa, Scer\GAL4^Ilp2.PR is a suppressor of abnormal body size phenotype of Scer\GAL4^Ilp2.PR, foxo^UAS.Tag:FLAG

(Nielsen et al., 2008)

NOT Suppressor of

Statement

Reference

Ilp2^UAS.cUa, Scer\GAL4^Ilp2.PR is a non-suppressor of decreased body size | adult stage phenotype of Scer\GAL4^Ilp2.PR, flz^GD1886

(Pathak et al., 2021)

sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR is a non-suppressor of decreased body size phenotype of Ilp2^GD15756, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

sNPF-R^UAS.cLa, Scer\GAL4^Ilp2.PR is a non-suppressor of decreased body size phenotype of Ilp1^GD2398, Scer\GAL4^Ilp2.PR

(Lee et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Ilp2.PR, rpr^UAS.C has wing phenotype, suppressible | heat sensitive by Ilp2^hs.PR

(Rulifson et al., 2002)

NOT suppressed by

Statement

Reference

Scer\GAL4^Ilp2.PR, rpr^UAS.C has follicle cell phenotype, non-suppressible by Ilp2^hs.PR

(LaFever and Drummond-Barbosa, 2005)

Suppressor of

Statement

Reference

Scer\GAL4^Ilp2.PR/Hsap\TBC1D7^UAS.cRa is a suppressor of ommatidium | cell non-autonomous phenotype of TBC1d7^KO

(Ren et al., 2018)

Scer\GAL4^Ilp2.PR/Hsap\TBC1D7^UAS.cRa is a suppressor | partially of wing phenotype of TBC1d7^KO

(Ren et al., 2018)

Stim^UAS.cAa, Scer\GAL4^Ilp2.PR, Orai^UAS.cZa is a suppressor of wing phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Stim^UAS.cAa/Scer\GAL4^Ilp2.PR is a suppressor of wing phenotype of Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Partially rescues

Scer\GAL4^Ilp2.PR/Dop2R^UAS.cDa partially rescues Dop2R^attP

(Deng et al., 2019)

TBC1d7^UAS.cRa/Scer\GAL4^Ilp2.PR partially rescues TBC1d7^KO

(Ren et al., 2018)

TBC1d7^125Q.UAS/Scer\GAL4^Ilp2.PR partially rescues TBC1d7^KO

(Ren et al., 2018)

Scer\GAL4^Ilp2.PR/Itpr^UAS.cVa partially rescues Itpr^ug3/Itpr^ka1091

(Subramanian et al., 2013)

Scer\GAL4^Ilp2.PR/Itpr^UAS.cVa partially rescues Itpr^ug3/Itpr^ka1091

(Agrawal et al., 2010)

Scer\GAL4^Ilp2.PR/Itpr^UAS.cVa partially rescues Itpr^wc703/Itpr^ug3

(Agrawal et al., 2010)

Scer\GAL4^Ilp2.PR/Itpr^UAS.cVa partially rescues Itpr^sv35/Itpr^ug3

(Agrawal et al., 2009)

Scer\GAL4^Ilp2.PR, Scer\GAL4^Ddc.PL, Itpr^UAS.cVa partially rescues Itpr^sv35/Itpr^ug3

(Agrawal et al., 2009)

Fails to rescue

Nrg^167.UAS/Scer\GAL4^Ilp2.PR fails to rescue Nrg⁸⁴⁹

(Clements et al., 2021)

Nrg^180.I.UAS/Scer\GAL4^Ilp2.PR fails to rescue Nrg⁸⁴⁹

(Clements et al., 2021)

Scer\GAL4^Ilp2.PR/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

dysc^UAS.long/Scer\GAL4^Ilp2.PR fails to rescue dysc^s168/dysc^c03838

(Jepson et al., 2012)

Scer\GAL4^Ilp2.PR, inc^f00285 fails to rescue inc^f00285

(Stavropoulos and Young, 2011)

ERR^UAS.cTa/Scer\GAL4^Ilp2.PR fails to rescue ERR²/ERR¹

(Tennessen et al., 2011)

Scer\GAL4^Ilp2.PR/Ns3^UAS.Venus fails to rescue Ns3^G0431

(Kaplan et al., 2008)

homer^UAS.Tag:MYC/Scer\GAL4^Ilp2.PR fails to rescue homer^R102

(Urizar et al., 2007)

Nf1^UAS.cWa/Scer\GAL4^Ilp2.PR fails to rescue Nf1^unspecified

(Walker et al., 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37516

w^*; P{Ilp2-GAL4.R}2/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Scer\GAL4^IRP.PR

Scer\GAL4^Ilp2.PR

dilp2^Gal4

(Devineni et al., 2013)

Name Synonyms

Insulin-related peptide promoter construct of Rulifson

(Rulifson et al., 2002, Rulifson et al., 2002)

Secondary FlyBase IDs

References (186)

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