FlyBase Allele Report: Dmel\imd[UAS.cGa]

General Information

Symbol

Dmel\imd^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Georgel

FlyBase ID

FBal0138219

Feature type

allele

Associated gene

Dmel\imd

Associated Insertion(s)

Carried in Construct

P{UAS-imd.G}

Also Known As

UAS-imd

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Leulier et al., 2002, Georgel et al., 2001)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-imd.G}

Cytology

Nature of the lesion

Statement

Reference

Expression of the complete imd cDNA (GH20785) is under the control of UASt sequences.

(Georgel et al., 2001)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

imd

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates colorectal cancer

modeled by Ras85D^V12.UAS

(Bangi et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^hs.PB

(Georgel et al., 2001)

lethal - all die before end of larval stage, with Scer\GAL4^da.G32

(Georgel et al., 2001)

radiation sensitive, with Scer\GAL4^hs.PB

(Georgel et al., 2001)

some die during larval stage, with Scer\GAL4^da.G32

(Georgel et al., 2001)

viable, with Scer\GAL4^hs.PB

(Georgel et al., 2001)

Phenotype Manifest In

embryonic/larval fat body, with Scer\GAL4^hs.PB

(Georgel et al., 2001)

Detailed Description

Statement

Reference

Expression of imd^Scer\UAS.cGa under the control of Scer\GAL4^byn-Gal4 does not lead to any significant increase in dissemination of hindgut cells into the abdominal cavity, as compared to controls.

(Bangi et al., 2012)

Expression of imd^Scer\UAS.cGa under the control of Scer\GAL4^c564 increases the survival of flies that have been injected with both E.coli and the fungal peptide Destruxin A.

(Pal et al., 2007)

The fat bodies of imd^Scer\UAS.cGa; Scer\GAL4^hs.PB flies have increased levels of cell death compared to wild-type. The proportion of imd^Scer\UAS.cGa; Scer\GAL4^hs.PB pupae (24 hours APF) surviving to adulthood after UV irradiation (50,000 μJ/cm²) is significantly lower than for wild-type.

(Georgel et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^da.G32, imd^UAS.cGa has lethal | larval stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^da.G32

(Georgel et al., 2001)

Scer\GAL4^hs.PB, imd^UAS.cGa has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^hs.PB

(Georgel et al., 2001)

Enhancer of

Statement

Reference

imd^UAS.cGa, Scer\GAL4^byn-Gal4 is an enhancer of abnormal cell migration | adult stage | progressive phenotype of Ras85D^V12.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^da.G32, imd^UAS.cGa has embryonic/larval fat body phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^da.G32

(Georgel et al., 2001)

Enhancer of

Statement

Reference

imd^UAS.cGa, Scer\GAL4^byn-Gal4 is an enhancer of adult hindgut phenotype of Ras85D^V12.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

imd^UAS.cGa, Scer\GAL4^byn-Gal4 is an enhancer of adult abdomen phenotype of Ras85D^V12.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of imd^Scer\UAS.cGa enhances the dissemination of hindgut cells seen in flies expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^byn-Gal4.

(Bangi et al., 2012)

The larval lethality of imd^Scer\UAS.cGa; Scer\GAL4^da.G32 is rescued by BacA\p35^Scer\UAS.cHa. Increased levels of cell death seen in the fact bodies of imd^Scer\UAS.cGa; Scer\GAL4^hs.PB flies are suppressed by BacA\p35^Scer\UAS.cHa.

(Georgel et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

imd^UAS.cGa/Scer\GAL4^hs.PB rescues imd¹

(Georgel et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

imd^Scer\UAS.cGa

imd^UAS.cGa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Georgel

(Leulier et al., 2002)

Secondary FlyBase IDs

References (20)

Report Sections

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