FB2025_01 , released February 20, 2025
Allele: Dmel\Sirt1UAS.DsRed(Unk)
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General Information
Symbol
Dmel\Sirt1UAS.DsRed(Unk)
Species
D. melanogaster
Name
FlyBase ID
FBal0138384
Feature type
allele
Associated gene
Dmel\Sirt1
Associated Insertion(s)
Carried in Construct
P{UAS-Sirt1-DsRed}
Key Links
Transgenic product class
wild_type
(Tulin et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tulin et al., 2002)
Mutagen
in vitro construct
(Tulin et al., 2006, Tulin et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Sirt1-DsRed}
Cytology
Description

UAS regulatory sequences drive expression of Sirt1 tagged with a DsRed(Unk) fluorescent protein.

(Tulin et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sirt1
Tagged with
DsRed(Unk)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Sir2Scer\UAS.T:Disc\RFP under the control of Scer\GAL4da.G32 causes chromatin compaction, reduces nucleolar size and induces variegation.

      (Tulin et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav-C155/Sirt1UAS.DsRed(Unk) partially rescues Sirt12A-7-11

      (Engel et al., 2016)
      Comments

      Expression of Sirt1Scer\UAS.T:Disc\RFP under the control of Scer\GAL4elav-C155 fails to rescue the reduced ethanol sensitivity, but does rescue the reduced tolerance to repeated ethanol exposure seen in Sirt12A-7-11/Sirt12A-7-11 flies.

      (Engel et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sir2Scer\UAS.T:Disc\RFP
      Sirt1Scer\UAS.T:Disc\RFP
      Sirt1UAS.DsRed(Unk)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)