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General Information
Symbol
Dmel\Chrac-14KG01051
Species
D. melanogaster
Name
FlyBase ID
FBal0138535
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{SUPor-P}mus201KG01051 insertion maps within a dicistronic processed transcript that encodes two non-overlapping open reading frames (Chrac-14 and mus201).

Insertion components
P{SUPor-P}mus201KG01051
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Chrac-14KG01051 mutant flies are viable and fertile, and do not show any obvious developmental defects.

After γ irradiation, Chrac-14KG01051 flies are unable to hatch, and virtually all flies display major developmental defects, including wing deformation and tumor formation. Most irradiated Chrac-14KG01051 mutant flies are unable to balance their bodies or fly and die within 24 hours of irradiation treatment.

Brains from irradiated Chrac-14KG01051 mutant larvae exhibit a failure to arrest damaged cells before entering mitosis, resulting in more cells undergoing mitosis, despite damage from irradiation, compared to controls. Anaphase figures in irradiated Chrac-14KG01051 mutant tissues sugget that cells do not arrest in G2/M but actually proceed through mitosis and therefore do not have a functional G2/M checkpoint. Whereas control cells display a G2-M arrest, Chrac-14KG01051 mutant cells show an almost normal cell-cycle profile with only slightly higher G2-M counts and a normal number of cells in S-phase after irradiation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Chrac-14KG01051
Chrac14KG01051
Name Synonyms
Secondary FlyBase IDs
    References (3)