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General Information
Symbol
Dmel\BruceE16
Species
D. melanogaster
Name
FlyBase ID
FBal0138571
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EP} in CG6293EP3731 has caused a deletion of the 3' end of Bruce, removing 10 kb of Bruce genomic DNA.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant females have a significant increase in the number of degenerating egg chambers during mid-oogenesis compared to wild type.

Well-fed BruceE16 mutant flies display increased levels of autophagy (punctate Lysotracker staining) in region two of the germarium and in stage eight degenerating egg chambers compared to controls.

In contrast to wild type, the ovaries of well-fed BruceE16 mutant flies contain a large number of degenerating stage eight egg chambers.

An increased number of apoptotic (TUNEL positive) cells are seen in region two cysts in well-fed BruceE16 mutant flies than are seen in wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

BruceE16 is a non-enhancer of increased cell death phenotype of hidGMR.PH

Phenotype Manifest In
Enhancer of
Statement
Reference

BruceE16 is an enhancer of eye phenotype of grimGMR.PH

BruceE16 is an enhancer of eye phenotype of rprGMR.PH

NOT Enhancer of
Statement
Reference

BruceE16 is a non-enhancer of eye phenotype of hidGMR.PH

Additional Comments
Genetic Interactions
Statement
Reference

The addition of BruceE16 enhances the cell death phenotype in the eye seen in grimGMR.PH or rprGMR.PH animals, but not WGMR.PH.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)