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General Information
Symbol
Dmel\sggS9E.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0140940
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a mutated form of the SGG10 sgg cDNA (carries the amino acid replacement S9E).
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of sggS9E.Scer\UAS under the control of Scer\GAL4455.2 results in a variable cleft notum phenotype and reduction in size of the scutellum. Expression of sggS9E.Scer\UAS under the control of Scer\GAL4vg.PM results in nicking of the wing margin, a reduction in wing size and wing to notum transformations. Expression of sggS9E.Scer\UAS under the control of Scer\GAL4sca-537.4 results in many animals dying as pupae. Sparse wing margin bristles and some notching of the wing and loss or tiny thoracic chaetae is seen.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Expression of one copy of dominant-negative sggS9E.Scer\UAS in the developing eye, has no effect on toxicity due to expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1. However two copies of sggS9E.Scer\UAS partially suppresses Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1-induced eye depigmentation, with decreased black spots, more regular compound eye structure, and increased pigment cells.
Expression of sggS9E.Scer\UAS partially suppresses the decrease in median and maximum lifespan seen in flies expressing Hsap\APPArctic.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav.Switch.PO from 2 day post-eclosion onwards (expression induced by feeding flies RU486). The climbing behaviour defects are fully rescued.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sggS9E.Scer\UAS
sggS9E.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)