FB2025_01 , released February 20, 2025
Allele: Dmel\sggS9E.UAS
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General Information
Symbol
Dmel\sggS9E.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0140940
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{UAS-sgg.S9E}
Key Links
Transgenic product class
missense_variant
(Bourouis, 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bourouis, 2002)
Mutagen
in vitro construct
(Bourouis, 2002)
Progenitor genotype
Carried in construct
P{UAS-sgg.S9E}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of the SGG10 sgg cDNA (carries the amino acid replacement S9E).

(Bourouis, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sgg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPArctic.UAS.Tag:SS(nec)
      (Sofola et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of sggS9E.Scer\UAS under the control of Scer\GAL4455.2 results in a variable cleft notum phenotype and reduction in size of the scutellum. Expression of sggS9E.Scer\UAS under the control of Scer\GAL4vg.PM results in nicking of the wing margin, a reduction in wing size and wing to notum transformations. Expression of sggS9E.Scer\UAS under the control of Scer\GAL4sca-537.4 results in many animals dying as pupae. Sparse wing margin bristles and some notching of the wing and loss or tiny thoracic chaetae is seen.

      (Bourouis, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of one copy of dominant-negative sggS9E.Scer\UAS in the developing eye, has no effect on toxicity due to expression of Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1. However two copies of sggS9E.Scer\UAS partially suppresses Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1-induced eye depigmentation, with decreased black spots, more regular compound eye structure, and increased pigment cells.

      (Jia et al., 2013)

      Expression of sggS9E.Scer\UAS partially suppresses the decrease in median and maximum lifespan seen in flies expressing Hsap\APPArctic.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav.Switch.PO from 2 day post-eclosion onwards (expression induced by feeding flies RU486). The climbing behaviour defects are fully rescued.

      (Sofola et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sggS9E.Scer\UAS
      sggS9E.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)