Flies show eye overgrowth.
Adults expressing upd1GMR.PB
have a dramatically enlarged eye.
Early third larval instar eye discs in animals expressing upd1GMR.PB
are the same size as controls. However, at approximately 110 hours after egg deposition (middle third larval instar) the eye discs become larger than those of controls.
Expression of upd1GMR.PB
results in an eye overgrowth phenotype and the formation of dorsal folds in the eye.
Flies carrying one copy of upd1GMR.PB
have greatly enlarged eyes, with dramatic dorsal outgrowths. The eyes are not rough and the external morphology of the eye and the position of the interommatidial bristles is relatively normal. Photoreceptor differentiation generally appears normal in flies carrying one copy of upd1GMR.PB
, although occasionally an ommatidium showing loss or gain of a photoreceptor is seen. There is no increase in cell volume of photoreceptors or their support cells. Rotation of the R7 photoreceptor cell occurs normally in upd1GMR.PB
third instar larvae, but abnormal ommatidial rotation is seen in both dorsal and ventral parts of the adult eye. Eye discs expressing upd1GMR.PB
have more mitotic cells in the region anterior to the morphogenetic furrow compared to wild-type discs. The second mitotic wave is not affected in upd1GMR.PB
eye discs. Cells derived from eye discs expressing upd1GMR.PB
which are derived from the part of the eye disc that is anterior to the furrow show an increase in the number of cells in G[]/M at 96 hours after egg laying (AEL) compared to wild-type discs and a further increase in the number of cells in G[]/M at 110 hours AEL. Homozygotes show pupal lethality. The enlarged eye phenotype seen in flies carrying one copy of upd1GMR.PB
is not modified if the flies are also carrying upd1YC43
/Y males are seen at low frequency, and are sterile due to defects in the development or morphogenesis of the male reproductive tract, which prevents the release of motile sperm.
Late third instar eye antennal imaginal disc complexes are overgrown.