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General Information
Symbol
Dmel\mblC.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0141036
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-MblC
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the mbl C isoform.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of mblC.Scer\UAS under the control of Scer\GAL4hs.PU results in a significant decrease in muscle area in dorsoventral sections of the thorax, and increased apoptosis and autophagy in adult muscle, after induction via heat shock, as compared to controls.

Expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev results in a rough eye phenotype.

mblE27 flies expressing mblC.Scer\UAS under the control of Scer\GAL4da.G32 do not undergo larval molting and die as first instar larvae up to three days after hatching.

Overexpression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev generates a moderately rough eye phenotype.

Targeted expression of mblC.Scer\UAS to the posterior wing compartment by Scer\GAL4e22c generates vein fusions and a lack of intervein material, affecting specially L4/5 veins.

Expression of mblC.Scer\UAS under the control of Scer\GAL4da.G32 does not result in a reduction in the fraction of embryos that are able to hatch compared to controls.

Expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev results in a rough eye phenotype. Severe polarity defects are seen and there is loss of photoreceptor cells within ommatidia. Expression of mblC.Scer\UAS under the control of Scer\GAL469B results in patches of ectopic vein material and ectopic veins in the wing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

A Df(2L)sc19-8/Df(2L)TW137 background strongly suppresses external eye morphology phenotypes found upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A Hsp70AbEY01148 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A jumuEY10708 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A jumuL70 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A jumuL70 mutant background reduces L4/L5 vein fusion events and also ameliorates several other aspects of the mblC.Scer\UAS (under the control of Scer\GAL4e22c) phenotype such as loss of laminar wing tissue or anterior intervein.

A DpEY09085 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A DpKG00660 ; Dp49Fk-1 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A amosRoi-1; amosScer\UAS.cGa mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev resulting in a lethal phenotype.

A amosTft-RM11 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A Aly02267 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A tsuEP567 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A tsuKG04415 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A aret01284 aretBG01566 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A aretGS12289 aretPA mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A nonA4b18 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

A nonAf00870 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A rprGMR.PH mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A th4 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A th5 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A Traf4GS2154 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A Traf4EP578 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A tutlGS13843 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A tutlk14703 ; tutl01085 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG15435GS11154 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG15435KG05006 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG17323NP7067 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A Elp3NP0434 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A Elp3KG02386 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG5790NP1233 mutant background results in lethality with expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG17323GS9130 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG17323KG03187 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG31751NP1565 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

A CG15625k10217 mutant background enhances the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4T80.

Xenogenetic Interactions
Statement
Reference

Co-expression of mblC.Scer\UAS partially suppresses the decreased muscle area and increased autophagy, but not the increased apoptosis seen in flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4hs.PU in response to heat shock; but does not rescue the shortened lifespan of flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4Mhc.PW.

Complementation and Rescue Data
Comments

The embryonic lethality of mblE16/mblE27 animals is partially rescued by expression of mblC.Scer\UAS under the control of Scer\GAL4da.G32; 70.9% of the embryos hatch.

The embryonic lethality of mblE16/mblE27 animals is only slightly rescued by expression of mblC.Scer\UAS under the control of Scer\GAL4Mef2.PR; 9.1% of the embryos hatch.

71.43% of mblE16/mblE27 embryos expressing mblC.Scer\UAS under the control of Scer\GAL4da.G32 hatch into larvae (in contrast to 0% of mblE16/mblE27 embryos) and the hypercontracted abdomen phenotype is greatly reduced.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
mblC.Scer\UAS
mblC.UAS
mmC.Scer\UAS
Name Synonyms
Secondary FlyBase IDs
    References (13)