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General Information
Symbol
Dmel\hamUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Moore
FlyBase ID
FBal0141095
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-ham
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a full length ham cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of hamScer\UAS.cMa under the control of Scer\GAL4pnt-14-94 (limited to a 24 hour period using Scer\GAL80ts.αTub84B) results in type II neuroblasts with a reduced diameter. A number of cells begin upregulating ase and downregulating the Scer\GAL4 driver, indicating a loss of type II neuroblast identity.

Expression of hamScer\UAS.cMa in type I neuroblasts under the control of Scer\GAL4ase.neuro (limited to a 48 hour period using Scer\GAL80ts.αTub84B) results in 80% neuroblast loss, and the remaining neuroblasts have fewer progeny, are smaller and often show nuclear pros expression.

Expressing hamUAS.cMa under the control of Scer\GAL4sca-109-68 results in disrupted notal microchaeta, with either a tormogen (socket) cell partially converted into an ectopic hair-like structure or two complete trichogen (hair) cells and no tormogen cell.

Expression of hamScer\UAS.cMa under the control of Scer\GAL4neur-GAL4-A101 results in a "balding" of the adult notum.

Expression of hamScer\UAS.cMa under the control of Scer\GAL4sca-109-68 in all cells of the external sensory organ lineage leads to the loss of both the external cell branch-derived trichogen and tormogen. Expression of hamScer\UAS.cMa under the control of Scer\GAL4neur-GAL4-A101 in clones in the notum results in the loss of external cells in almost 100% of external sensory organs in the clone.

Expression of hamScer\UAS.cMa under the control of Scer\GAL4pros.PMG results in transformation of multidendritic neurons to external sensory neurons. When hamScer\UAS.cMa is expressed under the control of Scer\GAL4elav.PLu or Scer\GAL4109(2)80 the branching morphology of the arbors of the multidendritic neurons is substantially reduced, but not eliminated.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of hamScer\UAS.cMa under the control of Scer\GAL4neur-GAL4-A101 suppresses the gain of socket cells on the adult cuticle that is seen in seqU5 clones.

Expression of both svScer\UAS.cKa and hamScer\UAS.cMa under the control of Scer\GAL4neur-GAL4-A101 in clones in the notum results in the loss of external cells in almost 100% of external sensory organs in the clone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
hamScer\UAS.cMa
hamUAS.cMa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Moore
Secondary FlyBase IDs
    References (6)