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General Information
Symbol
Dmel\h674
Species
D. melanogaster
Name
FlyBase ID
FBal0141098
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos have abnormally shaped salivary glands; 40% have elongated, branched lumens, 30% have elongated, expanded lumens, 2% have short, expanded lumens and 28% are normal (elongated, unbranched lumens). The branching is due to defects in the early morphogenetic movements of salivary gland invagination; more cells appear to invaginate than normal. As in wild type, there is no cell proliferation within the salivary glands at all stages of salivary gland formation. Salivary gland cells of mutant embryos have increased apical areas compared to wild type. h22/h674, h25/h674 and hi22/h674 embryos have salivary glands with either branched or expanded lumens.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

hkb2 h674 double mutant embryos form salivary glands that are morphologically identical to those of hkb2 single mutants, although there is an increase in salivary glands that fail to internalise (from 0% in the single mutants to 19% in the double mutants).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
h674
Name Synonyms
Secondary FlyBase IDs
    References (2)