Expression of dapScer\UAS.cdNa completely suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU. The gross neural morphogenesis defects are also suppressed.
The Scer\GAL4en.PU-driven co-expression of BacA\p35UAS.cHa and dapUAS.cdNa leads to a longer sustained DNA damage response to ionizing ration (assessed by phospho-H2Av immunostaining) in the wing disc posterior compartment as compared to the BacA\p35UAS.cHa single expression or wild-type backgrounds.
Expression of dapScer\UAS.cdNa partially rescues the cell death and R7 photoreceptor loss seen when p53GUS.PB is expressed in third instar larval eye discs under the control of Scer\GAL4GMR.PU. The adult eye ablation phenotype is also partially rescued.
Co-expression of dapScer\UAS.cdNa and RbfScer\UAS.cDa in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu significantly reduces the number of dying cells observed. Vacuolar degeneration of the lamina is rescued in these animals.
Co-expression of dapScer\UAS.cdNa and cdc2E51Q.Scer\UAS in adult brains expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PLu significantly reduces the number of dying cells observed.
The rough-eye phenotype observed in animals expressing Hsap\MAPTV337M.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by co-expression of RhebAV4. This enhancement is blocked by co-expressing dapScer\UAS.cdNa and RbfScer\UAS.cDa.
The rough-eye phenotype observed in animals expressing Hsap\MJDtr.Q78.Scer\UAS.T:Ivir\HA1 in the eye under the control of Scer\GAL4GMR.PF is not modified by co-expression of dapScer\UAS.cdNa and RbfScer\UAS.cDa.