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General Information
Symbol
Dmel\commE39
Species
D. melanogaster
Name
FlyBase ID
FBal0141222
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Deletion of the comm transcription unit.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    commE39 mutants exhibit commissural defects but have no salivary gland defects.

    The commissures fail to form in mutant embryos.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    NOT suppressed by
    Enhancer of
    Statement
    Reference

    commE39/comm[+] is an enhancer of EW neuron phenotype of fra6/fra4

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Expression of either robo2ΔIg1.10xScer\UAS.T:Ivir\HA1,T:SS-wg, robo2ΔIg2.10xScer\UAS.T:Ivir\HA1,T:SS-wg or robo1::robo2R1I1+2.Scer\UAS.T:Ivir\HA1,T:SS-wg under the control of Scer\GAL4elav.PLu does not suppress the loss of commissure phenotype of homozygous commE39 embryos.

    Expression of robo1::robo2R2I1+2.Scer\UAS.T:Ivir\HA1,T:SS-wg under the control of Scer\GAL4elav.PLu strongly suppresses the loss of commissure phenotype of homozygous commE39 embryos.

    Expression of robo2Scer\UAS.T:Ivir\HA1,T:SS-wg under the control of Scer\GAL4sli.PS suppresses the loss of commissure phenotype of homozygous commE39 embryos.

    The commissural defects seen in fra4/fra6 embryos are enhanced in a heterozygous commE39/+ genetic background as shown by missing and thin commissures in many segments, as well as an increased frequency of non-crossing defects in a subset of of commissural neurons.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (4)