FlyBase Allele Report: Dmel\comm[E39]

General Information

Symbol

Dmel\comm^E39

Species

D. melanogaster

Name

FlyBase ID

FBal0141222

Feature type

allele

Associated gene

Dmel\comm

Associated Insertion(s)

Carried in Construct

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Georgiou and Tear, 2002)

Mutagen

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Deletion of the comm transcription unit.

(Georgiou and Tear, 2002)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Evans et al., 2015, Georgiou and Tear, 2002)

Phenotype Manifest In

commissure

(Evans et al., 2015, Kolesnikov and Beckendorf, 2005)

ventral nerve cord commissure

(Georgiou and Tear, 2002)

Detailed Description

Statement

Reference

comm^E39 mutants exhibit commissural defects but have no salivary gland defects.

(Kolesnikov and Beckendorf, 2005)

The commissures fail to form in mutant embryos.

(Georgiou and Tear, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

comm^E39 has abnormal neuroanatomy phenotype, suppressible by robo1::robo2^{R2I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^E39 has abnormal neuroanatomy phenotype, suppressible by robo2^{UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

NOT suppressed by

Statement

Reference

comm^E39 has abnormal neuroanatomy phenotype, non-suppressible by robo1::robo2^{R1I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^E39 has abnormal neuroanatomy phenotype, non-suppressible by robo2^{ΔIg1.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^E39 has abnormal neuroanatomy phenotype, non-suppressible by robo2^{ΔIg2.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

Enhancer of

Statement

Reference

comm^E39/comm[+] is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of fra⁶/fra⁴

(Yang et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

comm^E39 has commissure phenotype, suppressible by robo1::robo2^{R2I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^E39 has commissure phenotype, suppressible by robo2^{UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

NOT suppressed by

Statement

Reference

comm^E39 has commissure phenotype, non-suppressible by robo1::robo2^{R1I1+2.UAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^E39 has commissure phenotype, non-suppressible by robo2^{ΔIg1.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

comm^E39 has commissure phenotype, non-suppressible by robo2^{ΔIg2.10xUAS.Tag:HA,Tag:SS(wg)}/Scer\GAL4^elav.PLu

(Evans et al., 2015)

Enhancer of

Statement

Reference

comm^E39/comm[+] is an enhancer of EW neuron phenotype of fra⁶/fra⁴

(Yang et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either robo2^{ΔIg1.10xScer\UAS.T:Ivir\HA1,T:SS-wg}, robo2^{ΔIg2.10xScer\UAS.T:Ivir\HA1,T:SS-wg} or robo1::robo2^{R1I1+2.Scer\UAS.T:Ivir\HA1,T:SS-wg} under the control of Scer\GAL4^elav.PLu does not suppress the loss of commissure phenotype of homozygous comm^E39 embryos.

Expression of robo1::robo2^{R2I1+2.Scer\UAS.T:Ivir\HA1,T:SS-wg} under the control of Scer\GAL4^elav.PLu strongly suppresses the loss of commissure phenotype of homozygous comm^E39 embryos.

Expression of robo2^{Scer\UAS.T:Ivir\HA1,T:SS-wg} under the control of Scer\GAL4^sli.PS suppresses the loss of commissure phenotype of homozygous comm^E39 embryos.

(Evans et al., 2015)

The commissural defects seen in fra⁴/fra⁶ embryos are enhanced in a heterozygous comm^E39/+ genetic background as shown by missing and thin commissures in many segments, as well as an increased frequency of non-crossing defects in a subset of of commissural neurons.

(Yang et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

comm^E39 is not rescued by comm^UAS.cKa/Scer\GAL4^sim.P3.7

(Georgiou and Tear, 2002)

comm^E39 is not rescued by comm^UAS.cKa/Scer\GAL4^sli.PS

(Georgiou and Tear, 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

comm^E39

(Evans et al., 2015)

comm^e39

(Yang et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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