Allele Dmel\asf1¹

General Information
Symbol	Dmel\asf1¹	Species	D. melanogaster
Name		FlyBase ID	FBal0141250
Feature type	allele	Associated gene	Dmel\asf1

Map ( GBrowse )
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References sequence variant 3L:19,612,658..19,612,659 comment=A 2 base deletion causing a frameshift and leading to early translation termination. evidence=experimental (Moshkin et al., 2002)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The asf1¹ mutation deletes two nucleotides as base pair 380 relative to the 'start' codon, causing a frameshift after amino acid 126 and early termination. (Moshkin et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile \| germline clone (Moshkin et al., 2002) lethal \| larval stage (with Df(3L)kto2) (Moshkin et al., 2002) suppressor of variegation \| dominant, with In(1)w^m4h (Moshkin et al., 2002) suppressor of variegation \| dominant, with In(2)Heidi/+: (Moshkin et al., 2002)
Phenotype Manifest In
	ovary \| germline clone (Moshkin et al., 2002)
Detailed Description
	Statement Reference Germ-line clones of asf1¹ cause a complete block in oogenesis. asf1¹/Df(3L)kto2 is embryonic or larval lethal. asf1¹/+ suppresses PEV of eye colour in In(1)w^m4h hemizygous flies. asf1¹/+ suppresses PEV of eye colour in w¹¹⁸/Y, In(2)Heidi/+ flies. (Moshkin et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference asf1[+]/asf1¹ is a suppressor of increased cell death phenotype of Caf1-180^Scer\UAS.cSa, Scer\GAL4^ey.PH (Song et al., 2007) asf1[+]/asf1¹ is a suppressor of visible phenotype of Caf1-180^Scer\UAS.cSa, Scer\GAL4^ey.PH (Song et al., 2007)
Phenotype Manifest In
Suppressor of
Statement Reference asf1[+]/asf1¹ is a suppressor of eye phenotype of Caf1-180^Scer\UAS.cSa, Scer\GAL4^ey.PH (Song et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference Heterozygosity for asf1[1] has no effect on the ability of Caf1-180[Scer\UAS.P\T.cKa] expressed under the control of Scer\GAL4[Act5C.PI] to rescue the lethality of Caf1-180[3]/Y males. (Klapholz et al., 2009) The small-eye phenotype of flies expressing Caf1-180[Scer\UAS.cSa] under the control of Scer\GAL4[ey.PH] is suppressed by heterozygous asf1[1]. (Song et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	9547 asf1¹ red¹ e⁴/TM6B, Sb¹ Tb¹ ca¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	asf1¹ (Klapholz et al., 2009) l(3)76BDq¹ (Zhu et al., 2005)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Klapholz et al., 2009, Chromosoma 118(2): 235--248 CAF-1 is required for efficient replication of euchromatic DNA in Drosophila larval endocycling cells. [FBrf0207560] Song et al., 2007, Dev. Biol. 311(1): 213--222 CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory. [FBrf0200457] Zhu et al., 2005, Development 132(17): 3813--3822 Drosophila Pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans. [FBrf0187494] Moshkin et al., 2002, Genes Dev. 16(20): 2621--2626 Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery. [FBrf0152008]

Allele Dmel\asf11

Allele Dmel\asf1¹