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General Information
Symbol
Dmel\Wnt4C1
Species
D. melanogaster
Name
FlyBase ID
FBal0141321
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Reported as a 3 bp deletion of gluatamate 299, however, the nearest E residue is at 302.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

3bp deletion removes a highly conserved glutamate residue at position 299.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of Wnt4C1 has no effect on hemocyte proliferation in third instar larvae.

Wnt4C1/Wnt4EMS23 mutant exhibit occasional misrouting of ventral axons towards the dorsal lamina. In extreme cases, ventral axons appear as if they are about to project to ventral lamina but then veer towards the dorsal lamina. Ventral misrouting is seen in the larval optic stalk.

In ovaries from females homozygous for Wnt4C1, ovarioles exhibit a "branched ovariole" phenotype, in which multiple ovarioles are attached to one egg chamber.

Lethality acts in first or second larval instar. 10%-15% of mutants survive to adulthood. Survivors are sterile, though show no external defects. Phenotype of homozygotes is similar to that of hemizygotes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Wnt4C1 has neuroanatomy defective phenotype, enhanceable by hepr75

Enhancer of
Phenotype Manifest In
Enhanced by
Statement
Reference

Wnt4C1 has neuron phenotype, enhanceable by hepr75

Wnt4C1 has lamina phenotype, enhanceable by hepr75

Wnt4C1 has eye photoreceptor cell phenotype, enhanceable by hepr75

Enhancer of
Statement
Reference

Wnt4C1/Wnt4[+] is an enhancer of neuron phenotype of hepr75

Wnt4C1/Wnt4[+] is an enhancer of lamina phenotype of hepr75

Wnt4C1/Wnt4[+] is an enhancer of eye photoreceptor cell phenotype of hepr75

NOT Enhancer of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

No lateral transverse muscle defects are observed in Wnt2L Wnt4C1 double mutant stage 16 embryos.

Wnt2L and Wnt4C1 do not enhance the lateral transverse muscle attachment defects seen in Wnt5400 mutant stage 16 embryos.

A Wnt4C1/+ background enhances the hepr75 R axon misrouting phenotype. Along with ventral-to-dorsal misroutings, these mutants also show dorsal axons projecting to the medial region of the lamina.

A hepr75 background enhances the Wnt4C1/+ R axon misrouting phenotype. Along with ventral-to-dorsal misroutings, these mutants also show dorsal axons projecting to the medial region of the lamina.

Xenogenetic Interactions
Statement
Reference

One copy of Wnt4C1 strongly enhances the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (13)