Allele Dmel\Ubx^{YAAA.Scer\UAS}

General Information
Symbol	Dmel\Ubx^{YAAA.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0141332
Feature type	allele	Associated gene	Dmel\Ubx

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - amino acid replacement
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Galant et al., 2002) in vitro construct - regulatory fusion (Galant et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Amino acid replacement: P?A. Amino acid replacement: W?A. Amino acid replacement: M?A. Scer\UAS regulatory sequences drive expression of Ubx in which the YPWM motif has been mutated to YAAA. (Galant et al., 2002)
Carried in construct	P{UAS-Ubx.YAAA} (Galant et al., 2002, Sprecher et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryonic abdominal segment 1, with Scer\GAL4^arm.PS (Galant et al., 2002) embryonic abdominal segment 2 \| ectopic, with Scer\GAL4^arm.PS (Galant et al., 2002) embryonic brain, with Scer\GAL4^sca-537.4 (Sprecher et al., 2004) embryonic metathoracic segment, with Scer\GAL4^arm.PS (Galant et al., 2002)
Detailed Description
	Statement Reference Expression of Ubx^{YAAA.Scer\UAS} under the control of Scer\GAL4^sca-537.4 results in a lab-loss of function type phenotype in the embryonic brain. (Sprecher et al., 2004) Expression of Ubx^{YAAA.Scer\UAS} under the control of Scer\GAL4^arm.PS in embryos results in the transformation of the identity of third thoracic segment and the first abdominal segment to that of abdominal segment A2. (Galant et al., 2002)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference Ubx^{YAAA.Scer\UAS} has embryonic brain phenotype, non-suppressible by hth^Scer\UAS.cPa/Scer\GAL4^sca-537.4/exd^{Scer\UAS.NLS.T:Zzzz\FLAG} (Sprecher et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference The defect in the embryonic brain caused by expression of Ubx^{YAAA.Scer\UAS} under the control of Scer\GAL4^sca-537.4 is not suppressed if the embryos are also coexpressing both exd^{Scer\UAS.NLS.T:Zzzz\FLAG} and hth^Scer\UAS.cPa. (Sprecher et al., 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Ubx^{YAAA.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Sprecher et al., 2004, Mech. Dev. 121(6): 527--536 Hox gene cross-regulatory interactions in the embryonic brain of Drosophila. [FBrf0179451] Galant et al., 2002, Development 129(13): 3115--3126 Hox repression of a target gene: extradenticle-independent, additive action through multiple monomer binding sites. [FBrf0148969]

Allele Dmel\UbxYAAA.Scer\UAS

Allele Dmel\Ubx^{YAAA.Scer\UAS}