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General Information
Symbol
Dmel\Traf4EP578
Species
D. melanogaster
Name
FlyBase ID
FBal0141340
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Traf1EP578, EP(2)0578, EP(2)578, EP0578
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A P{EP} element is inserted in the 5' flanking region of Traf1.

Insertion components
P{EP}Traf4EP578
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous flies are resistant to V. cholerae infection compared to controls.

Scer\GAL4GMR.PF-mediated expression of Traf4EP578 results in rough eyes with disorganized arrays of ommatidia.

Homozygous Traf4EP578 mutant embryos appear normal.

Expression via Scer\GAL4fkh.PH produces a very strongly penetrant phenotype in the embryonic salivary gland of fewer cells in the glands.

Expression of Traf4EP578 under the control of Scer\GAL4GMR.PF results in a rough eye phenotype.

Overexpression of Traf1EP578, under the regulation of Scer\GAL4ap-md544 has no effect on thorax closure.

Expression of Traf1EP578 under the control of Scer\GAL4GMR.PF leads to a rough eye phenotype. Eyes have a reduced number of ommatidia, abnormally-shaped photoreceptor cells and an overall reduction in the size of the compound eye. This phenotype is more severe when two copies of Traf1EP578 are expressed.

The eye imaginal discs from transgenic flies overexpressing Traf1EP578 under the control of Scer\GAL4GMR.PF contain a highly increased number of apoptotic cells in the region posterior to the morphogenetic furrow in a gene dosage-dependent manner.

Expression of Traf1EP578 under the control of Scer\GAL4ey.PH results in eyes that are somewhat reduced in size. Flies expressing Traf1EP578 under the control of Scer\GAL4hs.2sev have wild-type eyes. Flies expressing Traf1EP578 under the control of Scer\GAL4en-e16E have wild-type wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The reduced eye phenotype caused by expression of Rab11N124I.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by co-expression of Traf4EP578.

A Traf4EP578 mutant background suppresses the moderately rough eye phenotype observed upon expression of mblC.Scer\UAS under the control of Scer\GAL4hs.2sev.

The thoracic cleft formation observed in parkScer\UAS.T:Hsap\MYC overexpression mutants (Scer\GAL4ap-md544) is suppressed by co-expression of Traf1EP578.

Coexpression of bskScer\UAS.cBa with Traf1EP578, under the control of Scer\GAL4GMR.PF, leads to an increase in the disturbance of the ommatidial array in the compound eye in comparison to the eye phenotype resulting from one copy overexpression of Traf1EP578. When hepScer\UAS.cBa is coexpressed with one copy of Traf1EP578, driven by Scer\GAL4GMR.PF, the number of ommatidia and the size of the compound eye are reduced to similar levels seen when two copies of Traf1EP578 are expressed. Expression of Traf1EP578, under the control of Scer\GAL4GMR.PF, in a hep1/Y background, results in the recovery of an eye of wild-type appearance. The number of apoptotic cells in eye dsics of this genotype are decreased compared to Scer\GAL4GMR.PF>Traf1EP578 discs.

Coexpression of Tak1Scer\UAS.cTa, with Traf1EP578, under the control of Scer\GAL4GMR.PF, an increased eye roughness and reduced eye size compared to expression of just Traf1EP578. Scer\GAL4GMR.PF>Traf1EP578 expression in a Tak11 background block the rough-eye phenotype caused by Traf1EP578 overexpression.

Coexpression of Traf2EP1516 with Traf1EP578, under the control of Scer\GAL4GMR.PF, does not alter the rough-eye phenotype caused by sole overexpression of Traf1EP578.

The rprGMR.PW eye phenotypes are significantly suppressed by heterozygosity for Traf1EP578.

Co-expression of CycEScer\UAS.cLa suppresses the small eye phenotype caused by expression of Traf1EP578 under the control of Scer\GAL4ey.PH.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Overexpression of Traf1EP578 under the control of Scer\GAL4hs.PB following a heat shock leads to an increase in Traf2 transcript levels.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Traf4EP578
Name Synonyms
Secondary FlyBase IDs
    References (13)