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General Information
Symbol
Dmel\Syx5EP2313
Species
D. melanogaster
Name
FlyBase ID
FBal0141353
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP(2)2313
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{EP} insertion is in the 5' regulatory region of Syx5, 803 bp upstream of the ATG, and in the correct orientation for expression of Syx5.

Insertion components
P{EP}Syx5EP2313
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Syx5EP2313 homozygotes exhibit small and irregularly shaped rhabdomeres, and the photoreceptor cells show an accumulation of ER and lipid droplets, as compared to controls.

Expression via Scer\GAL4fkh.PH results in a weakly penetrant 'degenerating glands' phenotype in the embryonic salivary gland.

Syx5EP2313/Syx5AR113 mutant males (with no Scer\GAL4 driver) have no motile sperm and appear to be defective in spermatid elongation. Mutant testes contain predominantly large, oval cysts and a few elongated bundles. Mutant testes also have abnormally large mitochondrial derivatives that are associated with multiple nuclei, indicative of a failure in cytokinesis. Mutant testes also exhibit an accumulation of unusual ovoid spermatid cysts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

The addition of Scer\GAL4da.G32 to Syx5EP2313/Syx5AR113 animals rescues the semilethality, mostly rescues the cytokinesis phenotype and the bundle elongation defects, but no motile sperm are seen, and males remain sterile.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Syx5EP2313 is homozygous lethal, but this lethality is likely to be due to second site mutations or the effect of the P{EP} element on adjacent genes, as it is only semilethal in combination with Syx5AR113. Driving Syx5EP2313 with Scer\GAL4da.G32 cannot rescue the lethality, also suggesting second site mutations.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
EP(2)2313
Syx5 EP2313P
Syx5EP2313
Name Synonyms
Secondary FlyBase IDs
    References (3)