Allele Dmel\Snr1^E1

General Information
Symbol	Dmel\Snr1^E1	Species	D. melanogaster
Name		FlyBase ID	FBal0141382
Feature type	allele	Associated gene	Dmel\Snr1
Also Known As	snr1^E1

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Zraly et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G256?. (Curtis et al., 2011) Single amino acid substitution in the conserved Repeat 2 region, implicated in a variety of protein-protein interactions. (Marenda et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	large body (Zraly et al., 2004) lethal \| recessive (Zraly et al., 2003) visible (with Snr1^R3) (Marenda et al., 2004) visible (with Snr1^SR21) (Zraly et al., 2004) visible \| dominant (Zraly et al., 2004, Marenda et al., 2004) visible \| dominant \| heat sensitive (Curtis et al., 2011)
Phenotype Manifest In
	wing (Zraly et al., 2004, Marenda et al., 2004) wing (with Snr1^R3) (Marenda et al., 2004) wing vein (with Snr1^SR21) (Zraly et al., 2004) wing vein \| ectopic (Zraly et al., 2004, Marenda et al., 2004) wing vein \| ectopic (with Snr1^R3) (Marenda et al., 2004) wing vein \| ectopic \| heat sensitive (Curtis et al., 2011)
Detailed Description
	Statement Reference Heterozygotes have ectopic wing vein material perpendicular to the posterior crossvein and anterior to longitudinal vein L2. These defects are seen at the permissive temperature (18[o]), with increased penetrance at the restrictive temperature (29[o]C). (Curtis et al., 2011) Heterozygotes show a weak extra vein extending distally from the posterior crossvein. Snr1^R3/Snr1^E1 flies have an extra vein phenotype in the wings, with extra vein material posterior to wing vein L5 and extending distally from the posterior crossvein. (Marenda et al., 2004) At 29^oC, 68% of heterozygous flies have an ectopic vein emanating from the posterior crossvein of the wing and 32% have wild-type wings. Snr1^SR21/Snr1^E1 adults have extensive disruptions of wing vein patterning at 29^oC. Heterozygous and homozygous adults have an increased body mass and wing size at 18^oC compared to controls. Homozygous flies have an increased cell number (cells per unit area in the wing) compared to controls. Homozygous stage P3 pupae have a significantly increased body mass compared to control pupae. (Zraly et al., 2004) Snr1^E1 is a temperature-sensitive allele of Snr1. Genetic analyses of Snr1^E1 reveal that it functions as an antimorph. (Marenda et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Snr1^E1 has visible \| dominant phenotype, enhanceable by aos[+]/aos⁰⁵⁸⁴⁵ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by aos[+]/aos^Δ7 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by Df(3L)81k19/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by Df(3L)AC1/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by Df(3L)vin5/+ (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, enhanceable by Df(3L)vin7/+ (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, enhanceable by Df(3R)by10/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by Df(3R)Exel7327/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by Hdac3^B/Hdac3[+] (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, enhanceable by Hdac3^N/Hdac3[+] (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, enhanceable by Jarid2[+]/Jarid2^EY02717 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by JHDM2[+]/JHDM2^EY01319 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by mor[+]/mor¹ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by mor³/mor[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by mor⁵/mor[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by mor⁶/mor[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by PSR^EY07193/PSR[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, enhanceable by Rpd3^5-5/Rpd3[+] (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, enhanceable by Rpd3⁰⁴⁵⁵⁶/Rpd3[+] (Zraly et al., 2004)
NOT Enhanced by
Statement Reference Snr1^E1 has visible \| dominant phenotype, non-enhanceable by CG10133[+]/CG10133^KG04150 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-enhanceable by Df(1)19/+ (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, non-enhanceable by Jarid2[+]/Jarid2^EY02717-REV (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-enhanceable by Kdm4A[+]/Kdm4A^KG04636 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-enhanceable by lid^2REV/lid[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-enhanceable by Su(var)3-3[+]/Su(var)3-3^ΔN (Curtis et al., 2011)
Suppressed by
Statement Reference Hdac3^B, Snr1^E1/Snr1[+] has visible \| dominant phenotype, suppressible \| partially by brm² (Zraly et al., 2004) Rpd3⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has visible \| dominant phenotype, suppressible \| partially by brm² (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, suppressible \| partially by cdc2c[+]/cdc2c¹ (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, suppressible \| partially by CycE^JP/CycE^JP (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, suppressible \| partially by mor[+]/mor⁴ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by brm[+]/brm² (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by cdc2c³/cdc2c[+] (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, suppressible by CG2982[+]/CG2982^EP1316 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by CG13902^e01240/CG13902[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(1)ED6720/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(2L)BSC149/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(2L)BSC206/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(2L)ED354/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(2R)CX1/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(2R)Exel6055/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(2R)Exel8057/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(3L)ED4177/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(3L)Exel6119/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(3R)Exel6151/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Df(3R)Exel6190/+ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by E(Egfr)B56[+]/E(Egfr)B56^B56 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by Kdm2[+]/Kdm2^DG12810 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by lid[+]/lid¹⁰⁴²⁴ (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by lid^k06801/lid[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, suppressible by mor²/mor[+] (Curtis et al., 2011) Snr1^E1 has visible phenotype, suppressible \| partially by Df(2L)osp29/+ (Zraly et al., 2004)
NOT suppressed by
Statement Reference Snr1^E1 has visible \| dominant phenotype, non-suppressible by CG10133[+]/CG10133^KG04150 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-suppressible by Df(1)19/+ (Zraly et al., 2004) Snr1^E1 has visible \| dominant phenotype, non-suppressible by Jarid2[+]/Jarid2^EY02717-REV (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-suppressible by Kdm4A[+]/Kdm4A^KG04636 (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-suppressible by lid^2REV/lid[+] (Curtis et al., 2011) Snr1^E1 has visible \| dominant phenotype, non-suppressible by Su(var)3-3[+]/Su(var)3-3^ΔN (Curtis et al., 2011)
Enhancer of
Statement Reference Snr1^E1/Snr1[+] is an enhancer of visible \| dominant phenotype of Hdac3^B (Zraly et al., 2004)
Suppressor of
Statement Reference Snr1^E1/Snr1[+] is a suppressor of visible phenotype of Scer\GAL4^69B, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Marenda et al., 2004) Snr1^E1 is a suppressor of visible phenotype of CycE^JP (Zraly et al., 2004)
Other
Statement Reference Rpd3⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has visible \| dominant phenotype (Zraly et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference Snr1^E1 has wing phenotype, enhanceable by Df(3L)vin5/+ (Zraly et al., 2004) Snr1^E1 has wing phenotype, enhanceable by Df(3L)vin7/+ (Zraly et al., 2004) Snr1^E1 has wing phenotype, enhanceable by Hdac3^B/Hdac3[+] (Zraly et al., 2004) Snr1^E1 has wing phenotype, enhanceable by Hdac3^N/Hdac3[+] (Zraly et al., 2004) Snr1^E1 has wing phenotype, enhanceable by Rpd3^5-5/Rpd3[+] (Zraly et al., 2004) Snr1^E1 has wing phenotype, enhanceable by Rpd3⁰⁴⁵⁵⁶/Rpd3[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by +/Df(3R)6-7 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by ab¹/ab[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by aos[+]/aos⁰⁵⁸⁴⁵ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by aos[+]/aos^Δ7 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by ash1[+]/ash1¹⁷ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by ash1[+]/ash1²² (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by bs[+]/bs² (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by bs[+]/bs^k07909 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by bs⁰³²⁶⁷/bs[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by corto[+]/corto^l1 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by corto^07128b/corto[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by corto^tsT18/corto[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by cv¹/cv[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(2L)net62/+ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(2R)Px2/+ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(3L)81k19/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(3L)AC1/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(3L)vin5/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(3L)vin7/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(3R)by10/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Df(3R)Exel7327/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by E(z)[+]/E(z)⁶⁰ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Egfr[+]/Egfr^E1 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by ex⁶⁹⁷/ex[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by gro^C105/gro[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Hdac3^B/Hdac3[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Hdac3^N/Hdac3[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Jarid2[+]/Jarid2^EY02717 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by JHDM2[+]/JHDM2^EY01319 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by kis[+]/kis¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by kis^k13416/kis[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by lawc[+]/lawc^EF250 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by mor[+]/mor¹ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by mor³/mor[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by mor⁵/mor[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by mor⁶/mor[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by net¹/net[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by PSR^EY07193/PSR[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by px[+]/px⁷² (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Rpd3^5-5/Rpd3[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by Rpd3⁰⁴⁵⁵⁶/Rpd3[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by RpII215[+]/RpII215³ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by RpII215[+]/RpII215⁸ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, enhanceable by sbb[+]/sbb⁰⁴⁴⁴⁰ (Marenda et al., 2004)
NOT Enhanced by
Statement Reference Snr1^E1 has wing phenotype, non-enhanceable by Df(1)19/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by bs[+]/bs¹³⁴⁸ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by CG10133[+]/CG10133^KG04150 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Df(1)19/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Dll⁵/Dll[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Dll⁹/Dll[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by E(spl)[+]/E(spl)m8-HLH¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by en[+]/en⁴ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by gro¹/gro[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Jarid2[+]/Jarid2^EY02717-REV (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Kdm4A[+]/Kdm4A^KG04636 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by kni[+]/kni^ri-1 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by lawc^p1/lawc[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by lid^2REV/lid[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Me[+]/Me¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Pcl[+]/Pcl¹¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by RpII215[+]/RpII215¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Sce[+]/Sce^D1 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Scm^D1/Scm[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Scr[+]/Scr⁷ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Scr[+]/Scr¹⁷ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by sd[+]/sd¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Su(var)3-3[+]/Su(var)3-3^ΔN (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Su(z)2^1.a1/Su(z)2[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Taf1[+]/Taf1¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Taf1[+]/Taf1^EP421/Scer\GAL4[-] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by Taf1[+]/Taf1^XS-2232 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by tkv^k16713/tkv[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by trx[+]/trx¹ (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing phenotype, non-enhanceable by ash1⁴ (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by ash1⁴ (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, non-enhanceable by trx^E2 (Marenda et al., 2004)
Suppressed by
Statement Reference Rpd3⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing phenotype, suppressible \| partially by brm² (Zraly et al., 2004) Rpd3⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing vein \| ectopic phenotype, suppressible \| partially by brm² (Zraly et al., 2004) Snr1^E1 has wing phenotype, suppressible \| partially by cdc2c[+]/cdc2c¹ (Zraly et al., 2004) Snr1^E1 has wing phenotype, suppressible \| partially by CycE^JP/CycE^JP (Zraly et al., 2004) Snr1^E1 has wing phenotype, suppressible \| partially by Df(2L)osp29/+ (Zraly et al., 2004) Snr1^E1 has wing phenotype, suppressible by cdc2c³/cdc2c[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible \| partially by cdc2c[+]/cdc2c¹ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible \| partially by CycE^JP/CycE^JP (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible \| partially by Df(2L)osp29/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible \| partially by mor[+]/mor⁴ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by ash1[+]/ash1¹⁷ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by ash1[+]/ash1²² (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Asx[+]/Asx¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by brm[+]/brm² (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by brm² (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by cdc2c³/cdc2c[+] (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by CG2982[+]/CG2982^EP1316 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by CG13902^e01240/CG13902[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(1)ED6720/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(2L)BSC149/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(2L)BSC206/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(2L)ED354/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(2R)CX1/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(2R)Exel6055/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(2R)Exel8057/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(3L)ED4177/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(3L)Exel6119/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(3L)iro-2/+ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(3R)Exel6151/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Df(3R)Exel6190/+ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by E(Egfr)B56[+]/E(Egfr)B56^B56 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by gpp[+]/gpp^61A (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by gpp[+]/gpp^94A (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by gpp[+]/gpp^XXV (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by Kdm2[+]/Kdm2^DG12810 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by lid[+]/lid¹⁰⁴²⁴ (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by lid^k06801/lid[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by mor²/mor[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by N^Ax-tsl/N[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by S[+]/S¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, suppressible by sens^Ly-1/sens[+] (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, suppressible by dpp^d-ho/dpp^d-ho (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, suppressible by dpp^s1/dpp^s1 (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, suppressible by rho^ve-1/rho^ve-1 (Marenda et al., 2004)
NOT suppressed by
Statement Reference Snr1^E1 has wing phenotype, non-suppressible by Df(1)19/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by bs[+]/bs¹³⁴⁸ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by CG10133[+]/CG10133^KG04150 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Df(1)19/+ (Zraly et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Dll⁵/Dll[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Dll⁹/Dll[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by E(spl)[+]/E(spl)m8-HLH¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by en[+]/en⁴ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by gro¹/gro[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Jarid2[+]/Jarid2^EY02717-REV (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Kdm4A[+]/Kdm4A^KG04636 (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by kni[+]/kni^ri-1 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by lawc^p1/lawc[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by lid^2REV/lid[+] (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Me[+]/Me¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Pcl[+]/Pcl¹¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by RpII215[+]/RpII215¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Sce[+]/Sce^D1 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Scm^D1/Scm[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Scr[+]/Scr⁷ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Scr[+]/Scr¹⁷ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by sd[+]/sd¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Su(var)3-3[+]/Su(var)3-3^ΔN (Curtis et al., 2011) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Su(z)2^1.a1/Su(z)2[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Taf1[+]/Taf1¹ (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Taf1[+]/Taf1^EP421/Scer\GAL4[-] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by Taf1[+]/Taf1^XS-2232 (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by tkv^k16713/tkv[+] (Marenda et al., 2004) Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by trx[+]/trx¹ (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing phenotype, non-suppressible by ash1⁴ (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by ash1⁴ (Marenda et al., 2004) Snr1^R3/Snr1^E1 has wing vein \| ectopic phenotype, non-suppressible by trx^E2 (Marenda et al., 2004)
Enhancer of
Statement Reference Snr1^E1/Snr1[+] is an enhancer of wing phenotype of Hdac3^B (Zraly et al., 2004) Snr1^E1/Snr1[+] is an enhancer of wing vein \| ectopic phenotype of Hdac3^B (Zraly et al., 2004) Snr1^E1/Snr1[+] is an enhancer of wing vein \| ectopic phenotype of net¹ (Marenda et al., 2004) Snr1^E1/Snr1[+] is an enhancer of wing vein phenotype of tkv¹ (Marenda et al., 2004) Snr1^E1/Snr1^E1 is an enhancer of wing vein phenotype of tkv¹ (Marenda et al., 2004, Marenda et al., 2004) Snr1^E1 is an enhancer of wing vein phenotype of Dl^6B (Marenda et al., 2004) Snr1^E1 is an enhancer of wing vein phenotype of Dl^9P (Marenda et al., 2004) Snr1^R3/Snr1^E1 is an enhancer of wing vein phenotype of Dl^9P (Marenda et al., 2004) Snr1^R3/Snr1^E1 is an enhancer of wing vein phenotype of dpp^s1 (Marenda et al., 2004)
NOT Enhancer of
Statement Reference Snr1^E1 is a non-enhancer of eye phenotype of S¹ (Marenda et al., 2004)
Suppressor of
Statement Reference Snr1^E1/Snr1[+] is a suppressor of posterior crossvein phenotype of Scer\GAL4^69B, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Marenda et al., 2004) Snr1^E1/Snr1[+] is a suppressor of wing vein L5 \| distal phenotype of Scer\GAL4^69B, brm^{K804R.Scer\UAS.T:Ivir\HA1} (Marenda et al., 2004) Snr1^E1 is a suppressor of eye phenotype of CycE^JP (Zraly et al., 2004) Snr1^E1 is a suppressor of wing phenotype of CycE^JP (Zraly et al., 2004) Snr1^E1 is a suppressor of wing vein L4 phenotype of H² (Marenda et al., 2004) Snr1^E1 is a suppressor of wing vein L5 phenotype of brm², rho^ve-1 (Marenda et al., 2004) Snr1^R3/Snr1^E1 is a suppressor of wing vein L5 phenotype of rho^ve-1 (Marenda et al., 2004)
NOT Suppressor of
Statement Reference Snr1^E1 is a non-suppressor of eye phenotype of S¹ (Marenda et al., 2004)
Other
Statement Reference Df(2R)CX1/+, Snr1^E1 has wing blade \| distal phenotype (Curtis et al., 2011) Df(2R)CX1/+, Snr1^E1 has wing blade \| posterior phenotype (Curtis et al., 2011) Pc¹, Snr1^E1 has wing phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc¹, Snr1^E1 has wing vein L2 phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc¹, Snr1^E1 has wing vein L4 phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc¹, Snr1^E1 has wing vein L5 phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc⁴, Snr1^E1 has wing phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc⁴, Snr1^E1 has wing vein L3 phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc⁴, Snr1^E1 has wing vein L4 phenotype (Marenda et al., 2004, Marenda et al., 2004) Pc⁴, Snr1^E1 has wing vein L5 phenotype (Marenda et al., 2004, Marenda et al., 2004) Psc^e22, Snr1^E1 has wing vein \| ectopic phenotype (Marenda et al., 2004, Marenda et al., 2004) Rpd3⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing phenotype (Zraly et al., 2004) Rpd3⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing vein \| ectopic phenotype (Zraly et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference Df(2R)CX1 dominantly suppresses the ectopic wing vein phenotype seen in Snr1[E1]/+ animals, and the double heterozygotes also show minor notching of posterior and distal parts of the wing blade. (Curtis et al., 2011) The loss of wing vein L5 and the posterior crossvein seen in animals expressing brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^69B at 18^oC is suppressed by Snr1^E1/+. At 29^oC, ash1¹⁷ suppresses the ectopic vein that extends distally from the posterior crossvein in Snr1^E1 animals. but enhances the extra vein material seen posterior of the L5 wing vein. At 29^oC, ash1²² suppresses the ectopic vein that extends distally from the posterior crossvein in Snr1^E1 animals. but enhances the extra vein material seen posterior of the L5 wing vein. 18% of Hsc70-4^L3929/Snr1^E1 animals have an incomplete L5 wing vein. Pc⁴/Snr1^E1 animals have incomplete L3, L4 and L5 wing veins (9%, 42% and 37% respectively) and moderate curling and disruption of the wing along the posterior wing margin. Pc¹/Snr1^E1 animals have incomplete L2, L4 and L5 wing veins (6%, 38% and 22% respectively) and moderate curling and disruption of the wing along the posterior wing margin. Psc^e22/Snr1^E1 wings have an extra vein between veins L3 and L4 in 44% of cases. Asx¹/Snr1^E1 wings have an extra vein between veins L3 and L4 in 11% of cases. vn^C221/Snr1^E1 animals show an incomplete or deleted anterior crossvein in 15% of wings. The Dl^9P thick vein phenotype is enhanced by Snr1^E1, especially near the distal tips of veins L3, L4 and L5. The Dl^9P thick vein phenotype is enhanced by Snr1^E1/Snr1^R3. The Dl^6B thick vein phenotype is enhanced by Snr1^E1, especially near the distal tips of veins L3, L4 and L5. dpp^s1/dpp^s1 Snr1^E1/Snr1^R3 animals show suppression of the Snr1 extra wing vein phenotype and enhancement of the dpp loss of vein phenotype in L5. The incomplete L4 wing vein phenotype seen in H² mutants is suppressed by Snr1^E1. The dominant rough eye phenotype caused by S¹ is not affected if Snr1^E1 is also present. Snr1^E1/Snr1^R3 suppresses the loss of wing vein L5 seen in rho^ve-1 homozygotes and rho^ve-1 suppresses the Snr1^E1/Snr1^R3 extra wing vein phenotype. Snr1^E1 suppresses the shortened L5 wing vein that results from the interaction between rho^ve-1 and brm². (Marenda et al., 2004) At 29^oC, CycE^JP/CycE^JP suppresses the ectopic wing vein phenotype of Snr1^E1/+; 12% of flies have an ectopic vein emanating from the posterior crossvein and 88% have wild-type wings. At 29^oC, Df(2L)osp29/+ suppresses the ectopic wing vein phenotype of Snr1^E1; 31% of flies have an ectopic vein emanating from the posterior crossvein and 69% have wild-type wings. The eye and wing phenotypes of CycE^JP are suppressed in a dosage- and temperature-dependent manner by Snr1^E1. At 29^oC, cdc2c¹/+ suppresses the ectopic wing vein phenotype of Snr1^E1/+; 15% of flies have an ectopic vein emanating from the posterior crossvein and 85% have wild-type wings. At 29^oC, cdc2c³/+ suppresses the ectopic wing vein phenotype of Snr1^E1/+; 100% of the flies have wild-type wings. At 29^oC, Rpd3^5-5/+ enhances the ectopic wing vein phenotype of Snr1^E1/+; 8% of flies have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. At 29^oC, Rpd3⁰⁴⁵⁵⁶/+ enhances the ectopic wing vein phenotype of Snr1^E1/+; 61% have an ectopic vein emanating from the posterior crossvein and 39% of flies have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. The ectopic wing vein phenotype seen in Rpd3⁰⁴⁵⁵⁶/Snr1^E1 and Hdac3^N/Snr1^E1 double heterozygotes at 29^oC is partially suppressed by brm²/+. At 29^oC, Hdac3^N/+ enhances the ectopic wing vein phenotype of Snr1^E1/+; 100% of flies have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. At 29^oC, Hdac3^B/Snr1^E1 double heterozygotes have an ectopic wing vein phenotype; 5% have normal wings, 58% have an ectopic vein emanating from the posterior crossvein and 37% have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. (Zraly et al., 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Snr1^R3 (Zraly et al., 2003) Snr1^SR21 (Zraly et al., 2003)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	snr1^E1 (Zraly et al., 2004, Marenda et al., 2004, Zraly et al., 2003, Curtis et al., 2011, Zraly et al., 2006) Snr1^E1
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Curtis et al., 2011, Dev. Biol. 350(2): 534--547 Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development. [FBrf0212876] Zraly et al., 2006, J. Biol. Chem. 281(46): 35305--35315 Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function. [FBrf0192654] Marenda et al., 2004, Dev. Biol. 267(2): 279--293 The Drosophila Brahma (SWI/SNF) chromatin remodeling complex exhibits cell-type specific activation and repression functions. [FBrf0174517] Zraly et al., 2004, Genetics 168(1): 199--214 SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. [FBrf0180290] Zraly et al., 2003, Dev. Biol. 253(2): 291--308 SNR1 is an essential subunit in a subset of Drosophila Brm complexes, targeting specific functions during development. [FBrf0155665]
Abstract	Marenda et al., 2003, A. Dros. Res. Conf. 44: 138 SNR1, a conserved component of the Brahma (Brm) chromatin remodeling complex, functions to restrict complex activities during wing vein development. [FBrf0154439]

Allele Dmel\Snr1E1

Allele Dmel\Snr1^E1