Open Close
General Information
Symbol
Dmel\Sirt15.26
Species
D. melanogaster
Name
FlyBase ID
FBal0141416
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sir25.26, dSir25.26
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    deletion
    Comment:
    A deletion resulting from the imprecise excision of P{PZ}Sirt105327a, removes sequences from -16 to +859 with respect to the Sirt1 transcription start. The start site was mapped to a base that corresponds to the 5' end of EST GB:LD07439.
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Imprecise excision of the P{lacW} element, resulting in a deletion of Sirt1 sequences from -16 to +859 (coding sequences of the adjacent gene, DnaJ-H, are intact).
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    Sir24.5/Sir25.26 males and females have normal lifespans.
    Unlike wild-type flies, the lifespan of Sirt14.5/Sirt15.26 flies is not extended by a diet of low-calorie food.
    Sir24.5/Sir25.26 flies are phenotypically normal. Under nonstress environmental conditions, the average median life span of Sir24.5/Sir25.26 males is slightly, but significantly less than that of heterozygous controls. The average life span is not significantly different from controls. Under stress conditions, the mean life span of Sir24.5/Sir25.26 males is not significantly different from controls. The median life span of Sir24.5/Sir25.26 males is significantly longer than that of controls.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressor of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference
    Phenotype Manifest In
    NOT Suppressor of
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    The increase in lifespan caused by expression of NaamScer\UAS.T:SV5\V5 under the control of Scer\GAL4elav.PLu is completely suppressed by Sir24.5/Sir25.26.
    Xenogenetic Interactions
    Statement
    Reference
    Sir24.5/Sir25.26 does not suppress the protective effect on axotomised olfactory receptor neurons in flies expressing Mmus\wldS.Scer\UAS under the control of Scer\GAL4Or22a.8197. No change is seen in the amount of Wallerian degeneration 15 days after injury.
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (5)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (5)