adult males show significantly decreased survival under starvation conditions at 3 weeks (but not 2 weeks) old, compared to controls (relative feeding rate is similar to controls at 1 or 2 weeks old). Sirt14.5
males fed ad libitum show significantly higher levels of glucose and glycogen (at 1 and 2 weeks old) and triglycerides (at 2 but not 1 weeks old) compared to wild type. In fasting conditions, mutants show significantly higher glucose levels (at 2 but not 1 week old), compared to wild type. Sirt14.5
mutants are insulin resistant by 2 weeks of age.
The median lifespan of Sir24.5
flies (mutant line generated by outcrossing the mutation into the Canton S background) responds in the same way as that of Canton S controls to a range of diets (from dietary restriction to fully-fed conditions).
Unlike wild-type flies, the lifespan of Sirt14.5
flies is not extended by a diet of low-calorie food.
flies are phenotypically normal. Under nonstress environmental conditions, the average median life span of Sir24.5
males is slightly, but significantly less than that of heterozygous controls. The average life span is not significantly different from controls. Under stress conditions, the mean life span of Sir24.5
males is not significantly different from controls. The median life span of Sir24.5
males is significantly longer than that of controls.