FlyBase Allele Report: Dmel\S6k[TE.UAS]

General Information

Symbol

Dmel\S6k^TE.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0141551

Feature type

allele

Associated gene

Dmel\S6k

Associated Insertion(s)

Carried in Construct

P{UAS-S6k.TE}

Also Known As

UAS-s6k^TE, UAS-S6K, UAS-S6K-TE, UAS-S6K^T398E, UAS-dS6K^TE

Key Links

Transgenic product class

missense_variant

(Barcelo and Stewart, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Barcelo and Stewart, 2002)

Mutagen

in vitro construct

(Barcelo and Stewart, 2002)

Progenitor genotype

Carried in construct

P{UAS-S6k.TE}

Cytology

Description

UASt regulatory sequences drive expression of a mutated form of S6k (carries the amino acid replacement T398E).

(Barcelo and Stewart, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

S6k

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

modeled by Pink1^B9

(Liu and Lu, 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

increased body size | pupal stage, with Scer\GAL4^Cg.PA

(Li et al., 2022)

increased cell size, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

visible, with Scer\GAL4^ap-md544

(Barcelo and Stewart, 2002)

Phenotype Manifest In

wing, with Scer\GAL4^ap-md544

(Barcelo and Stewart, 2002)

wing, with Scer\GAL4^nub-AC-62

(Resnik-Docampo and de Celis, 2011)

Detailed Description

Statement

Reference

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal shrinkage and disappearance of pupal neuroblasts.

(Homem et al., 2014)

Expression of S6k^TE.Scer\UAS using Scer\GAL4^nub-AC-62 results in abnormally large wings in which cell size is increased.

(Resnik-Docampo and de Celis, 2011)

Expression of S6k^TE.Scer\UAS under the control of Scer\GAL4^elav.PLu has little effect on neuromuscular junction growth.

(Shen and Ganetzky, 2009)

After 30 days of light/dark cycling, photoreceptors are preserved normally in Scer\GAL4^GMR.PU driven S6k^TE.Scer\UAS flies.

(Wang et al., 2009)

Expression of S6k^TE.Scer\UAS under the control of Scer\GAL4^ap-md544 results in wings which bend down (the wings bend down more than in flies expressing S6k^Scer\UAS.cMa under the control of Scer\GAL4^ap-md544).

(Barcelo and Stewart, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA/S6k^TE.UAS is a suppressor of decreased body size | pupal stage phenotype of Sgsf^KO

(Li et al., 2022)

Scer\GAL4^pHCl-2.PR/S6k^TE.UAS is a suppressor of abnormal developmental rate phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

Scer\GAL4^ppk.PG/S6k^TE.UAS is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of path^dg50/Df(3L)BSC773

(Lin et al., 2015)

S6k^TE.UAS, Scer\GAL4^nub-AC-62 is a suppressor of abnormal size phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

S6k^TE.UAS, Scer\GAL4^nub-AC-62 is a suppressor of decreased cell size phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

Scer\GAL4^αTub84B.PL/S6k^TE.UAS is a suppressor of abnormal cell size phenotype of mTor^ΔP

(Scott et al., 2004)

NOT Suppressor of

Statement

Reference

S6k^TE.UAS, Scer\GAL4^fln.IFM is a non-suppressor of flightless | progressive phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

S6k^TE.UAS, Scer\GAL4^ptc.PU is a non-suppressor of abnormal size | adult stage phenotype of CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

S6k^TE.UAS, Scer\GAL4^ptc.PU is a non-suppressor of abnormal size | adult stage phenotype of CCT4^NIG.5525R, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

S6k^TE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of abnormal neuroanatomy phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

S6k^TE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of increased cell growth rate phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^ppk.PG/S6k^TE.UAS is a suppressor | partially of larval multidendritic class IV neuron phenotype of path^dg50/Df(3L)BSC773

(Lin et al., 2015)

S6k^TE.UAS, Scer\GAL4^nub-AC-62 is a suppressor of wing phenotype of Scer\GAL4^nub-AC-62, hppy^UAS.cMa

(Resnik-Docampo and de Celis, 2011)

NOT Suppressor of

Statement

Reference

S6k^TE.UAS, Scer\GAL4^fln.IFM is a non-suppressor of wing phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

S6k^TE.UAS, Scer\GAL4^fln.IFM is a non-suppressor of nucleus | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

S6k^TE.UAS, Scer\GAL4^fln.IFM is a non-suppressor of myofibril | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

S6k^TE.UAS, Scer\GAL4^fln.IFM is a non-suppressor of indirect flight muscle cell | adult stage phenotype of LamC^R205W.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

S6k^TE.UAS, Scer\GAL4^fln.IFM is a non-suppressor of indirect flight muscle cell | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

S6k^TE.UAS, Scer\GAL4^ptc.PU is a non-suppressor of wing blade phenotype of CCT4^KK108551, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

S6k^TE.UAS, Scer\GAL4^ptc.PU is a non-suppressor of wing blade phenotype of CCT4^NIG.5525R, Scer\GAL4^ptc.PU

(Kim and Choi, 2019)

S6k^TE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of NMJ bouton phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

S6k^TE.UAS, Scer\GAL4^elav.PLu is a non-suppressor of neuromuscular junction phenotype of Atg1^UAS.cSa, Scer\GAL4^elav.PLu

(Shen and Ganetzky, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of LamC^UAS.cSa and S6k^TE.UAS under the control of Scer\GAL4^fln.IFM under the control of Scer\GAL4^fln.IFM does not lead to any obvious indirect flight muscle, wing posture or flight defects.

(Chandran et al., 2019)

Co-expression of S6k^TE.Scer\UAS diminishes the small wing and decreased wing cell size phenotypes seen in hppy^Scer\UAS.cMa, Scer\GAL4^nub-AC-62 wings.

(Resnik-Docampo and de Celis, 2011)

Co-expression of S6k^TE.Scer\UAS under the control of Scer\GAL4^elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1^Scer\UAS.cSa.

(Shen and Ganetzky, 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6912

w¹¹¹⁸; P{UAS-S6k.TE}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

S6k^TE.Scer\UAS

S6k^TE.UAS

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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