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General Information
Symbol
Dmel\S6kSTDE.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0141553
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-S6K.STDE, UAS-S6KSTDE, UAS-S6K-STDE
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a mutated form of S6k (carries the amino acid replacements S418D and T422E).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of S6kSTDE.Scer\UAS under the control of Scer\GAL4Tab2-201Y leads to a significant increase in axonal regrowth of mushroom body gamma neurons in P-stage brains cultured ex vivo.

Expression of S6kSTDE.Scer\UAS under the control of Scer\GAL4ap-md544 results in a bending downward of the wing blade.

Expression via Scer\GAL4wor.PA and Scer\GAL80ase.PN does not prevent the normal shrinkage and disappearance of pupal neuroblasts.

Expression of S6kSTDE.Scer\UAS under the control of Scer\GAL4elav.PLu has little effect on neuromuscular junction growth.

S6kSTDE.Scer\UAS expression, under the control of Scer\GAL4Ilp2 in fasted third instar larvae results in an attenuated feeding response to both liquid and solid foods. No significant difference was observed in the size or developmental rate of mutant larvae to wild-type controls.

Expression of S6kSTDE.Scer\UAS under the control of Scer\GAL4ap-md544 results in wings which bend down (the wings bend down more than in flies expressing S6kScer\UAS.cMa under the control of Scer\GAL4ap-md544).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of S6kSTDE.Scer\UAS under the control of Scer\GAL4Tab2-201Y partially rescues the gamma lobe regrowth defects of Eip75BΔ51/Eip75BΔ51 mushroom body neuron clones.

Expression of trblScer\UAS.T:Zzzz\FLAG suppresses the bending downward of the wing blade seen when S6kSTDE.Scer\UAS is expressed under the control of Scer\GAL4ap-md544, resulting in a flat wing blade.

Expression of S6kSTDE.Scer\UAS in Hr51LL04325 MARCM neuroblast clones partially suppresses the developmental regrowth defect. In these clones, γ axons do not occupy the entire adult lobe but instead grow to the dorsal and ventral extremities of the adult γ-lobe and in some cases only to its ventral portion.

Co-expression of S6kSTDE.Scer\UAS under the control of Scer\GAL4elav.PLu, fails to suppress the neuromuscular junction overgrowth phenotype found upon expression of Atg1Scer\UAS.cSa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
S6kSTDE.Scer\UAS
S6kSTDE.UAS
Name Synonyms
Secondary FlyBase IDs
    References (12)