The adulthood-only expression of S6kKQ.UAS under the combined control of Scer\GAL4C587 and Gal80[ts] leads to a progressive decrease in the number of germline stem cells in the germarium, and leads to defective wrapping of germ cysts by escort cells, as compared to controls.
Ectopic expression of S6kKQ.Scer\UAS under the Scer\GAL4elav-C155 driver does not alter the number of neuromuscular junction boutons in third instar larvae compared to controls.
In contrast to wild-type, transgenic flies expressing Scer\GAL4ppl.PP>S6kKQ.Scer\UAS and reared on medium supplemented with Apis mellifera royal jelly do not show increased body size. However, similarly to wild-type flies in response to royal jelly, they display shortened developmental time compared with flies reared on control medium.
Expression of S6kKQ.Scer\UAS under the control of Scer\GAL4Lsp2.PH rescues the increase in triglyceride levels and the heart defects normally caused by a high-fat diet.
Expression of S6kKQ.Scer\UAS under the simultaneous control of both Scer\GAL4Scer\UAS.cHa and Scer\GAL4tin.cBa does not rescue the increase in triglyceride levels caused by a high-fat diet. However, the heart defects normally caused by a high-fat diet are rescued in these animals.
Expression of S6kKQ.Scer\UAS, under the control of Scer\GAL4Ilp2 results in a 50% increase in the rate of third instar larval liquid-food intake and a significant feeding on solid food. No significant difference was observed in the size or developmental rate of mutant third instar larvae to wild-type controls. When fed ad libitum, S6kKQ.Scer\UAS (under the control of Scer\GAL4NPFR1.6.6) third instar larvae display hyperactive feeding of solid food. However they don't display any increase in the ingestion rate of richer liquid food.