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General Information
Symbol
Dmel\Pvrc02195
Species
D. melanogaster
Name
FlyBase ID
FBal0141570
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Pvrc2195, VegfrC2195, PBc2195
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

PBac{PB} insertion within the intron between exons 11 and 12.

Insertion components
PBac{PB}Pvrc02195
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In Pvrc02195 mutant embryos, the anterior pair of Malpighian tubules fail to migrate into the anterior half of the embryo, instead they are observed projecting posteriorly.

The hemocytes of Pvrc02195 embryos fail to migrate in a wild-type pattern, and at stage 15 these hemocytes are observed clumped together in the anterior part of the embryo. At stage 17, the ventral nerve cord (VNC) is shorter in Pvrc02195 embryos than in wild-type, indicating that the VNC fails to condense correctly in Pvrc02195 mutants. This phenotype is fully penetrant.

About 24% of Pvrc02195/+, PvrdsRNA.Scer\UAS, Scer\GAL4pnr-MD237 animals exhibit a split thorax phenotype.

Pvrc02195 homozygous clones have normal F-actin distribution, epithelial organization and polarity.

Border cell clusters in which all cells are homozygous for Pvrc02195 show delays in border cell migration, but the phenotype is incompletely penetrant and many border cell clusters complete their migration to the oocyte.

Mutants display a striking defect in hemocyte migration. Formation of hemocytes and their initial migrations are normal. By stage 11, posteriorly directed hemocytes reach the caudal margin normally. However unlike wild-type blood cells which rapidly enter the tail, blood cells in mutant embryos never enter the region, instead accumulating at the caudal margin. By stage 13 wild-type hemocytes are dispersed throughout the embryo, whereas mutant hemocytes are clumped together in aggregates concentrated in the anterior. No defects are detected in the CNS, muscles, and tracheal system, in mutant embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Pvrc02195/+, Df(3R)mbc-R1/+ animals exhibit extensive loss of larval lymph gland progenitors.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (15)