FB2025_01 , released February 20, 2025
Allele: Dmel\MybUAS.cFa
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General Information
Symbol
Dmel\MybUAS.cFa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Fitzpatrick
FlyBase ID
FBal0141650
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-DMyb
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of the full length Myb coding sequence.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of MybScer\UAS.cFa under the control of Scer\GAL4en-e16E or Scer\GAL4sd-SG29.1 results in malformed wing discs which are overgrown in the area where MybScer\UAS.cFa is overexpressed. Expression of MybScer\UAS.cFa under the control of Scer\GAL4en-e16E results in an increased number of cells in S phase in the posterior compartment of wing and leg discs compared to controls. Expression of MybScer\UAS.cFa under the control of Scer\GAL4en-e16E promotes S phase in cells in the zone of non-proliferating cells (ZNC) in the wing disc. No ZNC is detected in wing discs expressing MybScer\UAS.cFa under the control of Scer\GAL4sd-SG29.1. Expression of MybScer\UAS.cFa under the control of Scer\GAL4en-e16E or Scer\GAL4sd-SG29.1 results in a slight increase in apoptosis in the wing disc. Expression of MybScer\UAS.cFa under the control of Scer\GAL4sd-SG29.1 often results in scalloping of the wing. The overall size of the salivary glands of third instar larvae and of the individual nuclei within the glands is reduced compared to controls in animals expressing MybScer\UAS.cFa under the control of Scer\GAL4sd-SG29.1. BrdU incorporation is still detected in imaginal ring cells and the endoreplicating nuclei of the salivary glands of larvae expressing MybScer\UAS.cFa under the control of Scer\GAL4sd-SG29.1 or Scer\GAL4fkh.PB, as occurs in wild-type larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
MybScer\UAS.cFa
MybUAS.cFa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Fitzpatrick
Secondary FlyBase IDs
    References (2)