Allele Dmel\Myb^MH107

General Information
Symbol	Dmel\Myb^MH107	Species	D. melanogaster
Name		FlyBase ID	FBal0141652
Feature type	allele	Associated gene	Dmel\Myb

Allele class
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	Delta2-3 (Manak et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EP}Gβ13F^EP1071 (Manak et al., 2002)
Nature of the lesion	Statement Reference Deletion removing the promoter and 5' untranslated region of Myb (and the adjacent AlkB gene). (Beall et al., 2002) Imprecise excision of P{EP}Gβ13F^EP1071 resulted in deletion of a 3' portion of the original P element along with adjacent DNA including the entire AlkB gene as well the 5' untranslated region of Myb. (Manak et al., 2002)
Caused by aberration	Df(1)MH107 (Beall et al., 2002, Manak et al., 2002, Wen et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	cell cycle defective \| recessive (Manak et al., 2007) cytokinesis defective (Manak et al., 2002) increased cell death (Manak et al., 2002) lethal (Andrejka et al., 2011) lethal \| recessive (Beall et al., 2004) mitotic cell cycle defective (Manak et al., 2002, Wen et al., 2008) mitotic cell cycle defective, with Myb^{Nterm.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^da.G32 (Andrejka et al., 2011)
Phenotype Manifest In
	centrosome (Manak et al., 2002) chorion \| somatic clone (Beall et al., 2002) chromosome (Wen et al., 2008) condensed nuclear chromosome (Manak et al., 2007) crystal cell (Davidson et al., 2005) dorsal appendage \| somatic clone (Beall et al., 2002) embryonic/larval lymph gland (Davidson et al., 2005) G2 phase (Manak et al., 2002) hemocyte & nucleus (Davidson et al., 2005) mitosis & nuclear chromosome (Manak et al., 2002) mitotic anaphase (Manak et al., 2002) mitotic cell cycle (Manak et al., 2002) M phase of mitotic cell cycle (Manak et al., 2002) neuroblast (Wen et al., 2008) plasmatocyte (Davidson et al., 2005) S phase (Manak et al., 2002) spindle (Manak et al., 2002, Wen et al., 2008)
Detailed Description
	Statement Reference Embryos derived from females carrying homozygous Myb[MH107] germline clones crossed to wild type males are able to hatch at a similar rate to wild type. (Lewis et al., 2012) Myb[MH107] mutant neuroblasts display characteristics of chromosome condensation and are dramatically delayed in prometaphase/metaphase with persistently abnormal spindles. The initially bipolar spindle poles migrate abnormally, and the spindle itself is often rotated, bowed and/or mis-attached. (Wen et al., 2008) Mosaic analysis in third instar larval imaginal eye discs of Myb[MH107] mutant clones and adjacent twin spots does not reveal any abnormalities associated with the mutant cells regarding cell size and cell number as well as cell doubling time. In Myb[MH107] mutant clones in larval brain, neither S phase nor M phase are altered, nor is there an unusual overlap of DNA synthesis and chromosome condensation. Myb[MH107] mutant cells contribute to normal appearing clones in pupal and adult eyes. Eyes composed of entirely of Myb[MH107] mutant cells appear normal. Examination of Myb[MH107] mutant eye and wing imaginal discs reveals an increased frequency of cells with condensed chromosomes compared to controls. In Myb[MH107] mutant wing imaginal discs, small clustered masses of partially condensed chromatin are observed. Many individual nuclei contain several condensed masses adjacent to and within a single nuclear envelope, consistent with arrest and /or delay in early prophase. The apoptotic response to ionizing radiation appears normal in Myb[MH107] mutant wing imaginal disc cells. (Manak et al., 2007) Homozygous larvae are completely devoid of crystal cells and plasmatocyte numbers are reduced. The lymph glands of homozygous third instar larvae are undersized compared to those of control animals. The reduced number of hemocytes in the lymph gland have aberrant nuclei. Somatic clones of homozygous hemocytes can be recovered and are seen both in the lymph gland and in the hemolymph. These hemocytes show a phagocytosis defect, showing a 57-68% decrease in phagocytosis compared to control cells. (Davidson et al., 2005) Homozygous clones in stage 10 egg chambers do not contain subnuclear foci of BrdU incorporation in contrast to surrounding normal cells. Homozygous Myb^MH107 clones (Df(1)MH107 clones in which AlkB function has been rescued by AlkB^+t9.8) in the region of the egg chamber normally responsible for dorsal appendage formation result in greatly reduced dorsal appendages. The chorion is missing under the mutant follicle cell patch. (Beall et al., 2002) Late third instar Myb^MH107 mutant wing discs have a lower proportion of cells with G2 DNA content than wild-type. These mutant wing discs also exhibit a 2-3 fold increase in the number of cells with condensed chromosomes compared to wild-type. In many cases the chromosomes in mutant cells become "hyper-condensed". Some mutant cells exhibit overlap between M-phase and S phase: chromsome condensation and DNA replication can be detected in the same cells. There is also a substantial increase in apoptosis in Myb^MH107 mutant discs. Myb^MH107 mutant cells in the third instar larval brain with condensed chromosomes often contain one or no centrosomes. Centromeres are formed in these mutant cells, but they exhibit a variety of abnormalities, including monopolar spindle attachement, multipolar spindles and abnormalities in ploidy: about 5% of all mutant mitoses are aneuploid and 1-2% are polyploid. There is also a decrease in the proportion of cells in anaphase in Myb^MH107 mutant third instar larval brains to 4%, compared with 9% in wild-type. (Manak et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Myb^MH107, lin-52⁹³ has visible \| somatic clone \| adult stage phenotype, suppressible by mip130^1-36 (Lewis et al., 2012) Myb^MH107 has lethal \| recessive phenotype, suppressible by mip130^1-36 (Beall et al., 2004) Myb^MH107 has lethal \| recessive phenotype, suppressible by mip130^{1-723+1-36.5'}/mip130^{1-723+1-36.3'} (Beall et al., 2004)
NOT Enhancer of
Statement Reference Myb^MH107 is a non-enhancer of female semi-sterile phenotype of mip130^1-36 (Beall et al., 2004)
NOT Suppressor of
Statement Reference Myb^MH107 is a non-suppressor \| germline clone \| maternal effect of lethal \| embryonic stage \| germline clone \| maternal effect phenotype of lin-52⁹³ (Lewis et al., 2012) Myb^MH107 is a non-suppressor of female semi-sterile phenotype of mip130^1-36 (Beall et al., 2004) Myb^MH107 is a non-suppressor of female sterile phenotype of mip130^{1-723+1-36.5'}/mip130^{1-723+1-36.3'} (Beall et al., 2004) Myb^MH107 is a non-suppressor of visible \| somatic clone \| adult stage phenotype of lin-52⁹³ (Lewis et al., 2012)
Phenotype Manifest In
Suppressed by
Statement Reference Myb^MH107, lin-52⁹³ has eye \| somatic clone phenotype, suppressible by mip130^1-36 (Lewis et al., 2012) Myb^MH107, lin-52⁹³ has ommatidium \| somatic clone \| adult stage phenotype, suppressible by mip130^1-36 (Lewis et al., 2012) Myb^MH107, lin-52⁹³ has rhabdomere \| somatic clone \| adult stage phenotype, suppressible by mip130^1-36 (Lewis et al., 2012) Myb^MH107 has crystal cell phenotype, suppressible by Scer\GAL4^e33C/Ggal\B-Myb^Scer\UAS.cDa (Davidson et al., 2005) Myb^MH107 has embryonic/larval lymph gland phenotype, suppressible by Scer\GAL4^e33C/Ggal\B-Myb^Scer\UAS.cDa (Davidson et al., 2005) Myb^MH107 has hemocyte & nucleus phenotype, suppressible by Scer\GAL4^e33C/Ggal\B-Myb^Scer\UAS.cDa (Davidson et al., 2005)
NOT suppressed by
Statement Reference Myb^MH107 has crystal cell phenotype, non-suppressible by Scer\GAL4^e33C/Ggal\A-Myb^Scer\UAS.cDa (Davidson et al., 2005) Myb^MH107 has crystal cell phenotype, non-suppressible by Scer\GAL4^e33C/Ggal\c-Myb^Scer\UAS.cDa (Davidson et al., 2005)
NOT Suppressor of
Statement Reference Myb^MH107 is a non-suppressor \| germline clone \| maternal effect of embryo \| germline clone \| maternal effect phenotype of lin-52⁹³ (Lewis et al., 2012) Myb^MH107 is a non-suppressor of eye \| somatic clone phenotype of lin-52⁹³ (Lewis et al., 2012) Myb^MH107 is a non-suppressor of ommatidium \| somatic clone \| adult stage phenotype of lin-52⁹³ (Lewis et al., 2012) Myb^MH107 is a non-suppressor of rhabdomere \| somatic clone \| adult stage phenotype of lin-52⁹³ (Lewis et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Homozygous Myb[MH107] does not suppress the eye phenotypes seen in lin-52[93] mutant eye clones. Homozygous mip130[1-36] suppresses the eye phenotypes seen in Myb[MH107], lin-52[93] double mutant clones. The resulting triple mutant eyes appear completely normal. Approximately 2% of embryos derived from females carrying homozygous lin-52[93] Myb[MH107] double mutant germline clones crossed to wild type males are able to hatch, a similar rate to when females are maternally mutant for lin-52[93] alone. (Lewis et al., 2012) Hemocytes in the secondary lymph gland lobes of hop^Tum Myb^MH107 double mutant larvae fail to overproliferate and do not adopt the flattened shape characteristic of differentiated lamellocytes. Abnormal differentiation of lamellocytes is not seen in the secondary lymph gland lobes of Tl⁸ Myb^MH107 double mutant larvae. The lymph gland hemocytes fail to overproliferate in the double mutant larvae. (Davidson et al., 2005)
Xenogenetic Interactions
Statement Reference Expression of Ggal\B-Myb^Scer\UAS.cDa under the control of Scer\GAL4^e33C restores circulating crystal cells and crystal cells in the lymph gland in homozygous Myb^MH107 larvae. The mutant phenotype seen in the Myb^MH107 lymph glands are also rescued by expression of Ggal\B-Myb^Scer\UAS.cDa under the control of Scer\GAL4^e33C. Expression of Ggal\c-Myb^Scer\UAS.cDa or Ggal\A-Myb^Scer\UAS.cDa under the control of Scer\GAL4^e33C does not rescue circulating crystal cells in Myb^MH107 larvae. (Davidson et al., 2005)
Complementation & Rescue Data
Rescued by	Myb^MH107 is rescued by Myb^{Cterm.Scer\UAS.T:Avic\GFP-EGFP} (Wen et al., 2008) Myb^MH107 is rescued by Myb^{K172.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is rescued by Myb^{Scer\UAS.N.T:Avic\GFP-EGFP} (Wen et al., 2008) Myb^MH107 is rescued by Myb^{Scer\UAS.N.T:Disc\RFP} (Wen et al., 2008) Myb^MH107 is rescued by Myb^{T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is rescued by Scer\GAL4^da.G32/Myb^{DKD36.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is rescued by Scer\GAL4^da.G32/Myb^{FLK393.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is rescued by Scer\GAL4^da.G32/Myb^{N180.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is rescued by Scer\GAL4^da.G32/Myb^{PP374.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is rescued by Scer\GAL4^da.G32/Myb^{Scer\UAS.N.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is rescued by Scer\GAL4^e33C/Myb^Scer\UAS.cDa (Davidson et al., 2005) Myb^MH107 is rescued by Scer\GAL4^en-e16E/Myb^Scer\UAS.cMa (Manak et al., 2007)
Partially rescued by	Myb^MH107 is partially rescued by Myb^{Cterm.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{DQ617.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{E193.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{ED94.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{EDL475.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{KW606.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{RK523.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{STP410.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Myb^{TP435.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{C174.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{Cterm.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{DE196.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{DKD36.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{DQ617.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{FLK393.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{KW606.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{PP374.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011) Myb^MH107 is partially rescued by Scer\GAL4^da.G32/Myb^{TPT445.Scer\UAS.T:Avic\GFP-EGFP} (Andrejka et al., 2011)
Not rescued by	Myb^MH107 is not rescued by Myb^{Nterm.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011) Myb^MH107 is not rescued by Myb^{TPT445.T:Avic\GFP-EGFP}/Scer\GAL4^da.G32 (Andrejka et al., 2011)
Comments	Expression of Myb[Scer\UAS.N.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] rescues Myb[MH107] mutant lethality. Expression of Myb[Cterm.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 50% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C. Expression of Myb[Nterm.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] is unable to rescue Myb[MH107] mutant lethality. An increased number of PH3 positive cells are seen in the wing discs and these cells are delayed or arrested in prophase. Expression of Myb[TPT445.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 15% of the number of adult flies seen in wild type. No rescue is seen at 29[o]C. Expression of Myb[KW606.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 5% of the number of adult flies seen in wild type. No rescue is seen at 29[o]C. Expression of Myb[DQ617.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 10% of the number of adult flies seen in wild type. No rescue is seen at 29[o]C. Expression of Myb[DKD36.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 80% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C. Expression of Myb[PP374.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 50% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C. Expression of Myb[FLK393.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 30% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C. Expression of Myb[EDL475.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 55% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C. Expression of Myb[RK523.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 55% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C. Expression of Myb[T:Avic\GFP-EGFP] fully rescues Myb[MH107] mutant lethality and fertility at 18[o]C, 25[o]C and 29[o]C. Expression of Myb[TPT445.T:Avic\GFP-EGFP] is unable to rescue Myb[MH107] mutant lethality at either 25[o]C or 29[o]C. Weak rescue is seen at 18[o]C. Expression of Myb[DQ617.T:Avic\GFP-EGFP] is unable to rescue Myb[MH107] mutant lethality at either 25[o]C or 29[o]C. Weak rescue is seen at 18[o]C. Expression of Myb[KW606.T:Avic\GFP-EGFP] is unable to rescue Myb[MH107] mutant lethality at either 25[o]C or 29[o]C. Weak rescue is seen at 18[o]C. Expression of Myb[Cterm.T:Avic\GFP-EGFP] is unable to rescue Myb[MH107] mutant lethality at either 25[o]C or 29[o]C. Partial rescue is seen at 18[o]C. Expression of Myb[DKD36.T:Avic\GFP-EGFP] rescues Myb[MH107] mutant lethality at 25[o]C and 29[o]C. Expression of Myb[PP374.T:Avic\GFP-EGFP] rescues Myb[MH107] mutant lethality at 25[o]C and 29[o]C. Expression of Myb[FLK393.T:Avic\GFP-EGFP] rescues Myb[MH107] mutant lethality at 25[o]C and 29[o]C. Expression of Myb[EDL475.T:Avic\GFP-EGFP] rescues Myb[MH107] mutant lethality at 25[o]C and 29[o]C. Expression of Myb[RK523.T:Avic\GFP-EGFP] rescues Myb[MH107] mutant lethality at 25[o]C and 29[o]C. Expression of Myb[ED94.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 60% of the number of adult flies seen in wild type. Expression of Myb[K172.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] rescues Myb[MH107] mutant lethality at 25[o]C, resulting in a similar number of adult flies as in wild type. Expression of Myb[C174.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 85% of the number of adult flies seen in wild type. Expression of Myb[N180.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] rescues Myb[MH107] mutant lethality at 25[o]C, resulting in more adult flies than are seen in wild type. Expression of Myb[E193.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 90% of the number of adult flies seen in wild type. Expression of Myb[DE196.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 65% of the number of adult flies seen in wild type. Expression of Myb[SPS389.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 85% of the number of adult flies seen in wild type. Expression of Myb[STP410.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 85% of the number of adult flies seen in wild type. Expression of Myb[TP435.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[da.G32] partially rescues Myb[MH107] mutant lethality at 25[o]C, resulting in approximately 25% of the number of adult flies seen in wild type. (Andrejka et al., 2011) Expression of Myb[Scer\UAS.cMa] driven by Scer\GAL4[en-e16E] in the posterior compartment of Myb[MH107] mutant wing discs rescues the condensed chromatin phenotype. (Manak et al., 2007)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Df(1)MH107 (Andrejka et al., 2011) MH107 (Beall et al., 2002) myb^M107 (Lewis et al., 2012) Myb^MH107 (Andrejka et al., 2011, Manak et al., 2007) myb^MH107 (Beall et al., 2007, Lewis et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Lewis et al., 2012, Mol. Cell. Biol. 32(16): 3218--3227 Drosophila Lin-52 Acts in Opposition to Repressive Components of the Myb-MuvB/dREAM Complex. [FBrf0219063] Andrejka et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(42): 17438--17443 Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. [FBrf0216444] Wen et al., 2008, Genes Dev. 22(5): 601--614 Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF via the Myb-MuvB/dREAM complex. [FBrf0202994] Beall et al., 2007, Genes Dev. 21(8): 904--919 Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. [FBrf0200827] Manak et al., 2007, Nat. Cell Biol. 9(5): 581--587 Loss of Drosophila Myb interrupts the progression of chromosome condensation. [FBrf0201787] Davidson et al., 2005, Genetics 169(1): 215--229 Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. [FBrf0182711] Beall et al., 2004, Genes Dev. 18(14): 1667--1680 Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. [FBrf0179131] Beall et al., 2002, Nature 420(6917): 833--837 Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. [FBrf0155469] Manak et al., 2002, Proc. Natl. Acad. Sci. U.S.A. 99(11): 7438--7443 Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability. [FBrf0149163]

Allele Dmel\MybMH107

Allele Dmel\Myb^MH107