|Feature type||allele||Associated gene||Dmel\Mekk1|
|Also Known As||dMekk1Ur36|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Mutant flies are more resistant to tunicamycin compared to controls.
Mekk1[Ur36] mutant larvae exhibit a melanotic phenotype under normal food conditions. A "black dot" is seen in the posterior hindgut. The phenotype is exacerbated in response to salt stress.
Mekk1[Ur36] heterozygotes show enhanced w silencing in the In(1)w[m4] line. In contrast to controls, Mekk1[Ur36] mutant flies do not show relieved w silencing in the In(1)w[m4] line when embryos are exposed to heat-shock 0-3 hours after egg laying.
Mutant flies show normal levels of survival after infection after infection with E.coli, E.faecalis or A.fumigatus. Homozygous flies show a strong increase in sensitivity to oxidative stress induced by paraquat compared to controls.
Shows increased susceptibility to high osmolarity (0.2M NaCl). Effect less pronounced than reported in FBrf0139644. No immune reponse deficiency could be detected. Response to bacterial infection was not compromised. Wound healing appears normal.
Homozygotes and hemizygotes show no obvious morphological abnormalities. Response to heat stress and osmotic stress is defective. Viability of mutants relative to wild type is reduced by 20% at 30oC. Mutants die before eclosion when raised on 0.2M NaCl.
Mekk1Ur36/Mekk1Ur36 is a suppressor | partially of visible phenotype of Scer\GAL4GMR.PF, ninaEG69D.Scer\UAS
|Phenotype Manifest In|
Mekk1Ur36/Mekk1Ur36 is a suppressor | partially of eye phenotype of Scer\GAL4GMR.PF, ninaEG69D.Scer\UAS
Mekk1[Ur36]/Mekk1[Ur36] partially suppresses the eye defects caused by expression of ninaE[G69D.Scer\UAS] under the control of Scer\GAL4[GMR.PF]. The massive apoptosis seen in the larval eye discs of animals expressing ninaE[G69D.Scer\UAS] under the control of Scer\GAL4[GMR.PF] is suppressed by Mekk1[Ur36]/Mekk1[Ur36]. The time course of retinal degeneration seen in ninaE[G69D]/+ flies is delayed in a Mekk1[Ur36]/Mekk1[Ur36] background.
|Complementation & Rescue Data|
|Partially rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 8 )|
|Secondary FlyBase IDs|
|References ( 11 )|