FB2025_01 , released February 20, 2025
Allele: Dmel\IP3K1UY530
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General Information
Symbol
Dmel\IP3K1UY530
Species
D. melanogaster
Name
FlyBase ID
FBal0141720
Feature type
allele
Associated gene
Dmel\IP3K1
Associated Insertion(s)
P{Mae-UAS.6.11}IP3K1UY530
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Monnier et al., 2002, Monnier et al., 2002)
Progenitor genotype
Associated Insertion(s)
P{Mae-UAS.6.11}IP3K1UY530
Cytology
Description

P{Mae-UAS.6.11} insertion at +3bp relative to the start of the IP3K1 EST SD07279 transcript.

(Monnier et al., 2002)

P{Mae-UAS.6.11} insertion in IP3K1, at +3bp relative to the transcription start site.

(Monnier et al., 2002)
Allele components
Component
Use(s)
Inserted element
P{Mae-UAS.6.11}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 8
      modeled by Vap33P58S.UAS.Tag:FLAG
      (Sanhueza et al., 2015)
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of IP3K1UY530 under the control of Scer\GAL4da.G32 results in a strong increase in survival on medium containing 1% H2O2 compared to control flies. Flies expressing IP3K1UY530 under the control of Scer\GAL4da.G32 show no significant difference in resistance to paraquat compared to control flies. Flies expressing IP3K1UY530 under the control of Scer\GAL4da.G32 do not show feeding defects. Homozygous IP3K1UY530 flies are slightly more sensitive to H2O2 than control flies; the time to reach 50% mortality on medium containing H2O2 is reduced on average by 15% compared to controls. The penetrance of this phenotype is not complete.

      (Monnier et al., 2002)

      Expression of IP3K1UY530 under the control of Scer\GAL4da.G32 results in increased resistance to hydrogen peroxide compared to wild type.

      (Monnier et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      IP3K1[+]/IP3K1UY530 is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      IP3K1[+]/IP3K1UY530 is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased survival on medium containing 1% H2O2 of flies expressing IP3K1UY530 under the control of Scer\GAL4da.G32 is not altered if the flies are homozygous for Gap1sxt-BJ61.

      (Monnier et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      IP3K1UY530
      (Feuillette et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)