|Feature type||allele||Associated gene||Dmel\Apc2|
|Allele class||loss of function allele|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: Q406Q.
Amino acid replacement: ??@. Stop codon in Arm repeat.
|Phenotype Manifest In|
The cuticle of an average Apc2g41 maternal/zygotic embryo shows an anterior hole, is 50-60% the length of wild-type and has at most 2 patches of denticles remaining.
|Phenotype Manifest In|
|NOT suppressed by|
Apc2f90, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype
Embryos maternally and zygotically double mutant for Apc[Q8] and Apc2[f90] display a naked cuticle phenotype. Expression of Axn[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] is unable to restore normal-looking denticle belts in embryos that are maternally and zygotically mutant for Apc[Q8] and Apc2[f90]. Every single embryo exhibits a completely naked cuticle, without any sign of denticle restoration. Expression of Axn[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] restores normal-looking denticle belts in embryos derived from females containing Apc[Q8] Apc2[f90] double mutant germline clones crossed with wild type males. Expressing Axn[FGmut.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] does not suppress the naked cuticle phenotype seen in Apc[Q8] Apc2[f90] double mutant embryos. Only occasional individual denticles are seen.
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 4 )|