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General Information
Symbol
Dmel\trolp4
Species
D. melanogaster
Name
FlyBase ID
FBal0143153
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
trol4
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

larval brain & neuroblast

Detailed Description
Statement
Reference

trolp4 homozygous first instar larvae show reduced proliferation of neuroblasts.

Hemizygous brains show a bimodal distribution of larval neuroblast proliferation; 43% show proliferation within control values, while proliferation is decreased in 57% of cases.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

trolp4 has neuroblast | larval stage phenotype, enhanceable by bnl06916/bnl[+]

trolp4 has neuroblast | larval stage phenotype, enhanceable by btlLG19/btl[+]

trolp4 has larval neuroblast | larval stage phenotype, enhanceable by ttv[+]/ttv00681b

trolp4 has larval brain & neuroblast phenotype, enhanceable by eve3/eve[+]

NOT Enhanced by
Statement
Reference

trolp4 has neuroblast | larval stage phenotype, non-enhanceable by htlAB42/htl[+]

Suppressed by
Statement
Reference

trolp4 has neuroblast | larval stage phenotype, suppressible by CycEhs.PR

Additional Comments
Genetic Interactions
Statement
Reference

Reduction in neuroblast proliferation in trolp4 homozygous larvae is suppressed by heat shock of CycEhs.PR animals. Reduction in S phase larval neuroblasts per brain lobe in trolp4 homozygotes is enhanced by heterozygosity for bnl06916 or btlLG19 but not htlAB42. Of ttv00681b/+; trolp4/trolp4 larvae, 29% show increased numbers of S phase neuroblasts per brain lobe and while 5% show decreased numbers.

The proliferation defect seen in trolp4 animals is enhanced by one copy of eve3; 100% of animals show defective proliferation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)