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General Information
Symbol
Dmel\runCK.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0143250
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a mutated run carrying the amino acid replacements K199A and C127S.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of runCK.Scer\UAS under the control of Scer\GAL4MT14 results in the disappearance of the lamina plexus in the optic lobe of larvae, due to the axons of photoreceptors R2-R5 terminating in the medulla (normally they terminate at the lamina plexus).

Depending on the insertion line used, expressing runCK.UAS under the control of Scer\GAL4nos.PG results in a range of defects in head development and pair rule segmentation. As opposed to a strongly expressing insertion line, weak expression of runCK.UAS only represses the initial activation of en-positive odd-numbered parasegments, which then recover during the extended germ band stage.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
runCK.Scer\UAS
runCK.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)