FB2025_01 , released February 20, 2025
Allele: Dmel\qkr58E-3minus
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General Information
Symbol
Dmel\qkr58E-3minus
Species
D. melanogaster
Name
FlyBase ID
FBal0143273
Feature type
allele
Associated gene
Dmel\qkr58E-3
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Di Fruscio et al., 2003)
Progenitor genotype
qkr58E-3EP2493
(Di Fruscio et al., 2003)
Cytology
Description

Imprecise excision of the qkr58E-3EP2493 element in qkr58E-2 causes a 1.4kb deletion, spanning exons 1-5 of the qkr58E-3 gene.

(Di Fruscio et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants are viable and show no obvious morphological phenotype. Only 46% of eggs laid from homozygous females hatch. The unhatched eggs fall into three major phenotypic classes. 17.7% are short and fat in appearance, but have the proper amount of dorsal appendage material. 7% are normal in size but have little or no dorsal appendage material. The remainder have a normal appearance. Mutant animals have an increased susceptibility to E.coli infection. 30 and 40% of homozygous and heterozygous mutants survive respectively. Occassionally mutant adults exhibit cell overgrowth in the eye.

      (Di Fruscio et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      qkr58E-3[+]/qkr58E-3minus is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Suppressor of
      Statement
      Reference

      qkr58E-3minus is a suppressor of decreased cell death phenotype of rprGMR.PH

      (Di Fruscio et al., 2003)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      qkr58E-3[+]/qkr58E-3minus is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Suppressor of
      Statement
      Reference

      qkr58E-3minus is a suppressor of eye phenotype of rprGMR.PH

      (Di Fruscio et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      qkr58E-3minus is rescued by qkr58E-3Tag:MYC

      (Di Fruscio et al., 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kep1-
      (Di Fruscio et al., 2003)
      qkr58E-3minus
      (Titus et al., 2023, Feuillette et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)