|Feature type||allele||Associated gene||Dmel\mts|
|Mutagen||in vitro construct - regulatory fusion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
mts[dn181.Scer\UAS] under the control of Scer\GAL4[Act] results in an increase in neuroblast numbers compared to controls.
Larvae expressing mts[dn181.Scer\UAS] under the control of Scer\GAL4[elav.PLu] have aberrant bouton morphology and size, and disruption to the NMJ cytoskeleton, with an 88% increase in the levels of unbundled microtubules relative to wild-type. Boutons are observed filled with an unusually high number of splayed filaments.
Flies expressing mtsdn181.Scer\UAS under the control of Scer\GAL4tim.PE are arrhythmic with respect to locomotor activity. Flies expressing mtsdn181.Scer\UAS under the control of Scer\GAL4P2.4.Pdf show an increase in the period of locomotor activity rhythms compared to controls. The rhythms appear to be unstable; some flies have long periods with interspersed days of prolonged activity and others show multiple periodicities.
|Phenotype Manifest In|
A PP2A-B' heterozygote background significantly enhances the unbundling microtubule phenotype of neuronal mts[dn181.Scer\UAS] expression (under the control of Scer\GAL4[elav.PLu]), leading to a 46% increase in unbundled microtubules relative to mts[dn181.Scer\UAS] expression alone. In addition, the cytoskeletal morphology of these double mutants is more severely disrupted than in mts[dn181.Scer\UAS] mutants. Simultaneously inhibiting mts and PP2A-B' results in synapses in which microtubules are splayed or punctate through the normally stable core region of the synaptic terminal.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 4 )|