FB2025_01 , released February 20, 2025
Allele: Dmel\lok+tBa
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General Information
Symbol
Dmel\lok+tBa
Species
D. melanogaster
Name
FlyBase ID
FBal0143333
Feature type
allele
Associated gene
Dmel\lok
Associated Insertion(s)
Carried in Construct
P{mnk-rescued}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Brodsky, 2003.5.16)
wild_type
(Brodsky, 2003.5.16)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Brodsky, 2003.5.16)
wild_type
(Brodsky, 2003.5.16)
Mutagen
in vitro construct
(Brodsky, 2003.5.16, Takada et al., 2003)
Progenitor genotype
Carried in construct
P{mnk-rescued}
Cytology
Description

Consists of a XbaI/NotI genomic fragment starting 523 bases 5' to the start of transcription to 72 bases 3' to the end of transcription of the lok gene.

(Brodsky, 2003.5.16)
Allele components
Component
Use(s)
Regulatory region(s)
lok
Encoded product / tool
lok
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
2L:20,060,954..20,064,555 [+]
Comment:

Genomic fragment extending from 523bp upstream of the transcription start to 72bp downstream of the polyA site.

(Brodsky, 2003.5.16, Takada et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      lok+tBa rescues lokp6

      (Titen and Golic, 2008)

      lok+tBa rescues lokp6

      (Brodsky et al., 2004)

      lok+tBa rescues lokp6

      (Takada et al., 2003)
      Comments

      Expression of lok+tBa rescues the partial suppression of apoptosis seen in lokp6 mutant cells containing dicentric chromosomes (generated using Scer\FLP1hs.PP-induced recombination in chromosomes containing inverted Scer\FRT sites).

      (Titen and Golic, 2008)

      Expression of lok+tBa rescues the reduction in X-ray induced radiation seen in lokp6 mutant third instar larvae.

      (Brodsky et al., 2004)

      lok+tBa rescues the Bleomycin resistance phenotype seen in lokp6 embryos.

      (Takada et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lok+tBa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)