FB2025_01 , released February 20, 2025
Allele: Dmel\BsgSH1217
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General Information
Symbol
Dmel\BsgSH1217
Species
D. melanogaster
Name
FlyBase ID
FBal0143734
Feature type
allele
Associated gene
Dmel\Bsg
Associated Insertion(s)
P{lacW}BsgSH1217
Carried in Construct
Also Known As
Bsg1217
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Oh et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{lacW}BsgSH1217
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bsg1217/Df(2L)Exel7034 hemizygous flies are semi-lethal, with approximately 50% reaching third larval instar.

      Axonal targeting is not altered to a visible degree in Bsg1217/Df(2L)Exel7034 transheterozygotes. The proportion of very large boutons is greatly increased compared to controls. The observed increase in bouton size is associated with a concomitant reduction of both NMJ branching and bouton number, keeping the overall NMJ size close to normal.

      (Besse et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      BsgSH1217/Bsg[+] is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of sicilyE

      (Liu et al., 2017)

      BsgSH1217/Bsg[+] is a suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of MarfB

      (Liu et al., 2017)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      BsgSH1217/Bsg[+] is a suppressor | partially of adult optic lobe glial cell | somatic clone phenotype of sicilyE

      (Liu et al., 2017)

      BsgSH1217/Bsg[+] is a suppressor | partially of lipid droplet | somatic clone | adult stage phenotype of sicilyE

      (Liu et al., 2017)

      BsgSH1217/Bsg[+] is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of sicilyE

      (Liu et al., 2017)

      BsgSH1217/Bsg[+] is a suppressor | partially of adult optic lobe glial cell | somatic clone phenotype of MarfB

      (Liu et al., 2017)

      BsgSH1217/Bsg[+] is a suppressor | partially of lipid droplet | somatic clone | adult stage phenotype of MarfB

      (Liu et al., 2017)

      BsgSH1217/Bsg[+] is a suppressor of photoreceptor | somatic clone | adult stage | progressive phenotype of MarfB

      (Liu et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The lipid droplet accumulation in retinal glial cells as well as the photoreceptor degeneration observed in adult flies bearing ey>flip whole-eye clones mutant for either sicilyE or MarfB is ameliorated by combination with one copy of BsgSH1217.

      (Liu et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Bsg1217
      (Hunter et al., 2020, West et al., 2018, Liu et al., 2017)
      BsgSH1217
      (Liu et al., 2017)
      l(2)SH1217SH1217
      Name Synonyms
      Secondary FlyBase IDs
        References (5)