FB2025_01 , released February 20, 2025
Allele: Dmel\l(2)gd1SH0495
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General Information
Symbol
Dmel\l(2)gd1SH0495
Species
D. melanogaster
Name
FlyBase ID
FBal0143990
Feature type
allele
Associated gene
Dmel\l(2)gd1
Associated Insertion(s)
P{lacW}l(2)gd1SH0495
Carried in Construct
Also Known As
lgdSH495
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Oh et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{lacW}l(2)gd1SH0495
Cytology
Description

Insertion at the beginning of the second exon of the transcription unit.

(Jaekel and Klein, 2006)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pharates exhibit slight bristle and leg and wing defects.

      l(2)gd1SH0495/l(2)gd1d7 pharates exhibit: loss of notal bristles, duplications/quadruplications of notal socket cells at the expense of other cell fates of this organ, foreshortening (vein 4) or loss (veins 2 and 5) of vein tissue, ectopic formation of leg joints and a reduction of the tarsal region.

      (Jaekel and Klein, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      l(2)gd1d7/l(2)gd1SH0495 has leg joint | ectopic phenotype, suppressible | partially by PsnC1/Psn[+]

      (Jaekel and Klein, 2006)

      l(2)gd1d7/l(2)gd1SH0495 has tarsal segment phenotype, suppressible | partially by PsnC1/Psn[+]

      (Jaekel and Klein, 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for PsnC1 weakens the l(2)gd1SH0495/l(2)gd1d7 leg phenotypes.

      (Jaekel and Klein, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P-element is accompanied by reversion of the mutant phenotype.

      (Jaekel and Klein, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      l(2)SH0495SH0495
      l(2)gd1SH0495
      lgdSH495
      (Baeumers et al., 2020, Troost et al., 2012, Jaekel and Klein, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)