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General Information
Symbol
Dmel\jebSH0422
Species
D. melanogaster
Name
FlyBase ID
FBal0144029
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
jebl(2)SH0422
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A P{lacW} insertion in the first intron of jeb, 6.69kb downstream of the translation start codon.

Insertion components
P{lacW}l(2)SH0422SH0422
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

axon & photoreceptor cell R1 | somatic clone

axon & photoreceptor cell R2 | somatic clone

axon & photoreceptor cell R3 | somatic clone

axon & photoreceptor cell R4 | somatic clone

axon & photoreceptor cell R5 | somatic clone

axon & photoreceptor cell R6 | somatic clone

axon & photoreceptor cell R8 | somatic clone

Detailed Description
Statement
Reference

jebSH0422 mutant embryos show visceral muscle fusion defects and an absence of Fas3-positive gut structures.

R cells, target neurons and glia are normal in jebSH0422 eye mosaic clones.

Third larval instar animals with jebSH0422 clones in the eye disc show normal R cell axon targeting. Adults that contain jebSH0422 clones in the eye exhibit strong R cell projection defects. R8 axons frequently extend to the M6 layer, fail to enter the medulla or fasciculate with R8 axons in neighbouring columns. Analysis of jebSH0422 mosaics at pupal stages shows that the R cell projection errors begin in the medulla at around 55 hours APF.

jebSH0422 clones in lamina target neurons do not affect the projection of R cells.

The size, shape and array of lamina cartridges are irregular in adults that lack jeb function due to jebSH0422 clones in the eye. These lamina cartridges contain either less or more than the wild-type R cell profile. Extensions of R1-R6 axons projecting from individual ommatidia appear irregular and shortened; some R1-R6 axons appear not to defasciculate and other growth cones extend at shorter distances.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

R cell projection defects in flies carrying jebSH0422 clones in the eye are rescued by expression of jebScer\UAS.cPa under the control of Scer\GAL4GMR.PF.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
jebSH0422
l(2)SH0422SH0422
Name Synonyms
Secondary FlyBase IDs
    References (4)