Allele Dmel\ban^EP3622

General Information
Symbol	Dmel\ban^EP3622	Species	D. melanogaster
Name		FlyBase ID	FBal0144429
Feature type	allele	Associated gene	Dmel\ban
Also Known As	EP(3)3622

Allele class	hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Hipfner et al., 2002)
Mutagen	P-element activity (Raisin et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The "EP(3)3622" line contains two P{EP} elements (P{EP}ban^EP3622a and P{EP}ban^EP3622b) inserted in a back-to-back orientation at 61C in contig AE003469. (Hipfner et al., 2002)
Caused by insertion	P{EP}ban^EP3622a (Hipfner et al., 2002, Raisin et al., 2003, Bilen et al., 2006, Thompson and Cohen, 2006, Shcherbata et al., 2007) P{EP}ban^EP3622b (Hipfner et al., 2002, Raisin et al., 2003, Thompson and Cohen, 2006)
Cytology
Phenotypic Data
Phenotypic Class
	decreased cell death, with Scer\GAL4^GMR.PF (Thompson and Cohen, 2006) decreased cell number, with Scer\GAL4[-]: (Raisin et al., 2003) decreased cell number (with ban^UY3207), with Scer\GAL4[-]: (Raisin et al., 2003) decreased cell number (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002, Raisin et al., 2003) decreased cell number \| adult stage \| somatic clone (with ban^L1170a) (Shcherbata et al., 2007) decreased cell number \| adult stage \| somatic clone (with Df(3L)ban^Δ1) (Shcherbata et al., 2007) decreased cell number \| cell non-autonomous, with Scer\GAL4^en-e16E (Resino and Garcia-Bellido, 2004) decreased cell number \| larval stage \| somatic clone (with ban^L1170a) (Shcherbata et al., 2007) decreased cell number \| larval stage \| somatic clone (with Df(3L)ban^Δ1) (Shcherbata et al., 2007) decreased cell number \| pupal stage \| somatic clone (with ban^L1170a) (Shcherbata et al., 2007) decreased cell number \| pupal stage \| somatic clone (with Df(3L)ban^Δ1) (Shcherbata et al., 2007) decreased cell size, with Scer\GAL4^ap-md544 (Resino and Garcia-Bellido, 2004) decreased cell size, with Scer\GAL4^en-e16E (Resino and Garcia-Bellido, 2004) female sterile \| partially, with Scer\GAL4[-]: (Hipfner et al., 2002) female sterile \| partially (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002) increased cell death (Jaklevic et al., 2008) increased cell death (with ban^L1170a) (Jaklevic et al., 2008) increased cell number \| cell autonomous, with Scer\GAL4^en-e16E (Resino and Garcia-Bellido, 2004) increased cell size \| somatic clone, with Scer\GAL4^Act5C.PP (Hipfner et al., 2002) locomotor rhythm defective, with Scer\GAL4^P2.4.Pdf (Kadener et al., 2009) locomotor rhythm defective, with Scer\GAL4^tim.PE (Kadener et al., 2009) small body, with Scer\GAL4[-]: (Hipfner et al., 2002, Raisin et al., 2003) small body (with ban^UY3207), with Scer\GAL4[-]: (Raisin et al., 2003) small body (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002, Raisin et al., 2003) small body (with Df(3L)emc), with Scer\GAL4[-]: (Raisin et al., 2003) viable, with Scer\GAL4[-]: (Hipfner et al., 2002) viable (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Hipfner et al., 2002) visible, with Scer\GAL4^ap-md544 (Resino and Garcia-Bellido, 2004) visible, with Scer\GAL4^Bx-MS1096 (Hipfner et al., 2002) visible, with Scer\GAL4^en-e16E (Resino and Garcia-Bellido, 2004) visible, with Scer\GAL4^GMR.PF (Hipfner et al., 2002)
Phenotype Manifest In
	eye, with Scer\GAL4^GMR.PF (Hipfner et al., 2002, Thompson and Cohen, 2006) female germline stem cell \| adult stage \| somatic clone (with ban^L1170a) (Shcherbata et al., 2007) female germline stem cell \| adult stage \| somatic clone (with Df(3L)ban^Δ1) (Shcherbata et al., 2007) female germline stem cell \| larval stage \| somatic clone (with ban^L1170a) (Shcherbata et al., 2007) female germline stem cell \| larval stage \| somatic clone (with Df(3L)ban^Δ1) (Shcherbata et al., 2007) female germline stem cell \| pupal stage \| somatic clone (with ban^L1170a) (Shcherbata et al., 2007) female germline stem cell \| pupal stage \| somatic clone (with Df(3L)ban^Δ1) (Shcherbata et al., 2007) interommatidial bristle \| supernumerary, with Scer\GAL4^GMR.PF (Thompson and Cohen, 2006, Nolo et al., 2006) mesothoracic tergum, with Scer\GAL4^ap-md544 (Resino and Garcia-Bellido, 2004) microchaeta, with Scer\GAL4^ap-md544 (Resino and Garcia-Bellido, 2004) pigment cell \| supernumerary, with Scer\GAL4^GMR.PF (Nolo et al., 2006) wing, with Scer\GAL4[-]: (Raisin et al., 2003) wing, with Scer\GAL4^Bx-MS1096 (Hipfner et al., 2002) wing, with Scer\GAL4^en-e16E (Hipfner et al., 2002) wing (with ban^UY3207), with Scer\GAL4[-]: (Raisin et al., 2003) wing (with Df(3L)ban^Δ1), with Scer\GAL4[-]: (Raisin et al., 2003) wing (with Df(3L)emc), with Scer\GAL4[-]: (Raisin et al., 2003) wing \| posterior compartment, with Scer\GAL4^en-e16E (Resino and Garcia-Bellido, 2004)
Detailed Description
	Statement Reference Expression of ban[EP3622] under the control of Scer\GAL4[tim.PE] results in a dramatically lengthened circadian period when locomotor activity is assayed (the increase is almost 3 hours). Expression of ban[EP3622] under the control of Scer\GAL4[P2.4.Pdf] results in a lengthened circadian period when locomotor activity is assayed. (Kadener et al., 2009) ban[EP3622] eye disc clones show no cell death. (Tanaka-Matakatsu et al., 2009) ban[EP3622] homozygotes or ban[EP3622]/Df(3L)ban[Δ1] hemizygotes survive to adulthood and show wild-type levels of apoptosis. Imaginal discs in ban[EP3622] homo- and hemizygotes or ban[EP3622]/ban[L1170a] transheterozygotes show significantly higher levels of AO staining than wild-type, indicating that these mutants undergo IR-induced apoptosis more readily than wild-type. Phenotypes for ban[EP3622] homozygotes are more severe than those of ban[EP3622]/Df(3L)ban[Δ1] hemizygotes. ban[EP3622] homozygotes, ban[EP3622]/ban[L1170a] transheterozygotes and ban[EP3622]/Df(3L)ban[Δ1] hemizygotes exposed to 0-8000 R of X-rays show decreased survival to adulthood after irradiation. (Jaklevic et al., 2008) ban[L1170a]/ban[EP3622] mutant germline stem cells (GSCs) show maintenance and cell division defects when clones are generated during adult stages. When ban[L1170a]/ban[EP3622] clones are generated in larval and pupal stages the GSC loss is less severe. ban[EP3622]/Df(3L)ban[Δ1] mutant germline stem cells (GSCs) show maintenance and cell division defects when clones are generated during adult stages. When ban[EP3622]/Df(3L)ban[Δ1] clones are generated in larval and pupal stages the GSC loss is less severe. (Shcherbata et al., 2007) Expression of ban^EP3622 in the developing eye, under the control of Scer\GAL4^GMR.PF, causes the generation of extra interommatidial pigment and bristle cells. (Nolo et al., 2006) Expression of ban^EP3622 in the eye, driven by Scer\GAL4^GMR.PF, leads to eye overgrowth, due mainly to excess interommatidial cells. The number of cells undergoing apoptosis is reduced in these eyes, but this reduction is not great enough to account for all of the extra cells. The morphology of the eye is not affected. (Thompson and Cohen, 2006) Cells in the posterior compartment of the wing are 30.1% smaller than in controls in flies expressing ban^EP3622 under the control of Scer\GAL4^en-e16E. The area of the posterior compartment is increased by 19.1% in these flies compared to controls, and the number of cells in the posterior compartment is increased by 68.7%. The number of cells in the anterior compartment in flies expressing ban^EP3622 under the control of Scer\GAL4^en-e16E is reduced by 12.7% compared to controls. Expression of ban^EP3622 under the control of Scer\GAL4^ap-md544 results in a large increase in notum size and reduction in cell size in the notum. The density of chaetae in the acrostical region is increased by 17.5% compared to controls and is associated with a lower number of cells between microchaetae (4.52 compared to 5.34 in wild type). The total number of chaetae per heminotum is increased by 49% compared to wild type. (Resino and Garcia-Bellido, 2004) The body mass of ban^EP3622/Df(3L)emc flies is 68% that of control flies. The wing blade surface area is 84.3% that of controls. The body mass of ban^EP3622/Df(3L)ban^Δ1 flies is 80% that of control flies. The wing blade surface area is 89.6% that of controls. Cell size in the wing blade is 99.2% of controls and cell number in the wing blade is 91.1% that of controls. Heterozygotes have a normal body mass compared to controls. The body mass of homozygotes is 82% that of control flies. The wing blade surface area is 91.2% that of controls. Cell size in the wing blade is 100% of controls and cell number in the wing blade is 91.1% that of controls. The body mass of ban^EP3622/ban^UY3207 flies is 84% that of control flies. The wing blade surface area is 92.6% that of controls. Cell size in the wing blade is 99.3% of controls and cell number in the wing blade is 92.8% that of controls. (Raisin et al., 2003) The body mass of ban^EP3622/Df(3L)ban^Δ1 adults is only 78% of that of control flies. The body mass of homozygous adults is only 80% of that of control flies. The wing blade area of ban^EP3622/Df(3L)ban^Δ1 flies is only 90% of that of controls. This decrease is entirely due to a decrease in the number of cells, and is not due to a decrease in cell size. Expression of ban^EP3622 under the control of Scer\GAL4^en-e16E results in a significant increase in the ratio of posterior:anterior area of the wing compared to control wings. There is a statistically significant increase in the overall size of the wing compared to controls. Expression of ban^EP3622 under the control of Scer\GAL4^GMR.PF results in roughening and bulging of the eye, suggesting extensive outgrowth. Clones of cells expressing ban^EP3622 under the control of Scer\GAL4^Act5C.PP show the same distribution of cells in G1, S and G2 phases compared to wild-type cells, but the cells are 3% larger than the control cells. The cell doubling time is significantly reduced compared to controls. Expression of ban^EP3622 under the control of Scer\GAL4^Bx-MS1096 results in significant outgrowth of the entire wing, with the wings curving downwards. (Hipfner et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement Reference Scer\GAL4^Bx-MS1096, ban^EP3622 has visible phenotype, non-suppressible by Cdk4³/Cdk4³ (Hipfner et al., 2002)
Enhancer of
Statement Reference ban^EP3622/Df(3L)ban^Δ1 is an enhancer of increased cell death phenotype of Hsap\ATXN3^{tr.Q78.GMR.T:Ivir\HA1} (Bilen et al., 2006) ban^EP3622 is an enhancer of increased cell death \| somatic clone phenotype of Rbf^15aΔ (Tanaka-Matakatsu et al., 2009)
Suppressor of
Statement Reference ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of visible phenotype of rpr^GMR.PH (Brennecke et al., 2003) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of visible phenotype of W^GMR.PG/W^GMR.PG (Brennecke et al., 2003) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hpo^Scer\UAS.cUa (Nolo et al., 2006) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of W^Ala5.GMR (Brennecke et al., 2003) ban^EP3622/Scer\GAL4^hs.2sev is a suppressor of visible phenotype of Scer\GAL4^hs.2sev, ex^Scer\UAS.cBa (Hipfner et al., 2002) ban^EP3622/Scer\GAL4^tub.PU is a suppressor of cell lethal \| somatic clone phenotype of yki^Δ.w (Thompson and Cohen, 2006) Scer\GAL4^hh-Gal4/ban^EP3622 is a suppressor \| partially of cell size defective \| somatic clone phenotype of yki^B5 (Nolo et al., 2006) Scer\GAL4^ptc-559.1/ban^EP3622 is a suppressor of increased cell death phenotype of Scer\GAL4^ptc-559.1, W^EP30060 (Brennecke et al., 2003)
Other
Statement Reference Scer\GAL4^tub.PU, ban^EP3622, yki^Δ.w has increased cell size \| somatic clone phenotype (Thompson and Cohen, 2006)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ban^EP3622 has interommatidial bristle \| supernumerary phenotype, enhanceable by CycE^Scer\UAS.cRa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Nolo et al., 2006) Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ban^EP3622 has pigment cell \| supernumerary phenotype, enhanceable by CycE^Scer\UAS.cRa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Nolo et al., 2006)
NOT suppressed by
Statement Reference Scer\GAL4^Bx-MS1096, ban^EP3622 has wing phenotype, non-suppressible by Cdk4³/Cdk4³ (Hipfner et al., 2002)
Enhancer of
Statement Reference ban^EP3622, Scer\GAL4^ptc-559.1 is an enhancer of wing disc phenotype of Dp^Scer\UAS.cDa, E2f^Scer\UAS.cNa, Scer\GAL4^ptc-559.1 (Brennecke et al., 2003) ban^EP3622/Df(3L)ban^Δ1 is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.GMR.T:Ivir\HA1} (Bilen et al., 2006) ban^EP3622/Df(3L)ban^Δ1 is an enhancer of retina phenotype of Hsap\ATXN3^{tr.Q78.GMR.T:Ivir\HA1} (Bilen et al., 2006) ban^EP3622 is an enhancer of eye disc \| somatic clone \| third instar larval stage phenotype of Rbf^15aΔ (Tanaka-Matakatsu et al., 2009)
Suppressor of
Statement Reference ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of eye phenotype of rpr^GMR.PH (Brennecke et al., 2003) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor \| partially of eye phenotype of W^GMR.PG/W^GMR.PG (Brennecke et al., 2003) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of W^Ala5.GMR (Brennecke et al., 2003) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hpo^Scer\UAS.cUa (Nolo et al., 2006) ban^EP3622, Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, hpo^Scer\UAS.cUa (Nolo et al., 2006) ban^EP3622/Scer\GAL4^hs.2sev is a suppressor of eye phenotype of Scer\GAL4^hs.2sev, ex^Scer\UAS.cBa (Hipfner et al., 2002) ban^EP3622/Scer\GAL4^hs.2sev is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, ex^Scer\UAS.cBa (Hipfner et al., 2002) ban^EP3622/Scer\GAL4^tub.PU is a suppressor of wing disc \| somatic clone \| cell autonomous phenotype of yki^B5 (Neto-Silva et al., 2010) Scer\GAL4^hh-Gal4/ban^EP3622 is a suppressor \| partially of wing disc \| somatic clone phenotype of yki^B5 (Nolo et al., 2006) Scer\GAL4^nub-AC-62/ban^EP3622 is a suppressor of wing phenotype of hpo^Scer\UAS.cUa (Nolo et al., 2006)
Other
Statement Reference CycE^Scer\UAS.cRa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ban^EP3622, th^Scer\UAS.cHa has cone cell \| supernumerary phenotype (Nolo et al., 2006, Nolo et al., 2006, Nolo et al., 2006) CycE^Scer\UAS.cRa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ban^EP3622, th^Scer\UAS.cHa has eye photoreceptor cell \| supernumerary phenotype (Nolo et al., 2006, Nolo et al., 2006, Nolo et al., 2006) CycE^Scer\UAS.cRa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, ban^EP3622, th^Scer\UAS.cHa has interommatidial bristle \| supernumerary phenotype (Nolo et al., 2006, Nolo et al., 2006, Nolo et al., 2006) Scer\GAL4^tub.PU, ban^EP3622, dm^Scer\UAS.cZa, yki^B5 has wing disc \| somatic clone \| cell autonomous phenotype (Neto-Silva et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Expression of ban[EP3622] in wing disc clones (under the control of Scer\GAL4[tub.PU]) in yki[B5] mutant animals increases clone size compared to yki[B5] alone. Co-expression of dm[Scer\UAS.cZa] in this background fails to rescue the growth defect of yki[B5] mutant clones, and growth rates are similar to when ban[EP3622] is expressed alone in yki[B5] mutant discs. However, despite the small size of the clones, cell and nucleolar size are increased when dm[Scer\UAS.cZa] and ban[EP3622] are expressed in yki[B5] wing discs. (Neto-Silva et al., 2010) A significant increase in the level of cell death is observed in Rbf[15aΔ];ban[EP3622] double mutant eye disc clones. (Tanaka-Matakatsu et al., 2009) Coexpression of ban^EP3622 with hpo^Scer\UAS.cUa, both driven by Scer\GAL4^GMR.PF, significantly suppresses the eye defects and eliminates the apoptosis caused by hpo overexpression. Coexpression of ban^EP3622 with hpo^Scer\UAS.cUa in the wing, driven by Scer\GAL4^nub-AC-62, suppresses the Scer\GAL4^nub-AC-62>hpo^Scer\UAS.cUa small wing phenotype. Coexpression of CycE^Scer\UAS.cRa with ban^EP3622, under the control of Scer\GAL4^GMR.PF, enhances the extra ommatidial cell phenotype seen in Scer\GAL4^GMR.PF>ban^EP3622 pupal retinae. This phenotype is not enhanced by th^Scer\UAS.cHa. Coexpression of ban^EP3622, CycE^Scer\UAS.cRa and th^Scer\UAS.cHa, under the control of Scer\GAL4^GMR.PF, causes a large increase in interommatidial, cone and photoreceptor cells. (Nolo et al., 2006) Expression of ban^EP3622, under the control of Scer\GAL4^tub, in yki^Δ.w mutant clones generated in the wing disc rescues the lethality of these clones, resulting in clones that are larger than those generated in wild-type controls. (Thompson and Cohen, 2006) When E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa are driven by Scer\GAL4^ptc-559.1 cells in the wing disc overproliferate. The addition of ban^EP3622 enhances this phenotype. Fewer cells show pyknotic nuclei, though many cells still drop out of the epithelial layer. (Brennecke et al., 2003) EP3219^EP3219 combined with ban^EP3622 has little or no effect on growth. The wing overgrowth phenotype caused by expression of ban^EP3622 under the control of Scer\GAL4^Bx-MS1096 is not altered by Cdk4³/Cdk4³. Co-expression of ban^EP3622 almost completely suppresses the eye phenotype caused by expression of ex^Scer\UAS.cBa under the control of Scer\GAL4^hs.2sev. (Hipfner et al., 2002)
Xenogenetic Interactions
Statement Reference Reduction of ban activity through ban[EP3622]/Df(3L)ban[Δ1] enhances Hsap\MJD[tr.Q78.GMR.T:Ivir\HA1]-induced degeneration, such that flies are now born with more neuronal loss. (Bilen et al., 2006)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	^EP3622 (Tanaka-Matakatsu et al., 2009) ban^EP3622 (Meyer et al., 2006, Shcherbata et al., 2007, Yang et al., 2009, Jaklevic et al., 2008) banEP (Neto-Silva et al., 2010) EP3622 (Raisin et al., 2003) EP(3)3622 (Resino and Garcia-Bellido, 2004, Brennecke et al., 2003) EP³3622 (Kadener et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap. [FBrf0212043] Kadener et al., 2009, Genes Dev. 23(18): 2179--2191 A role for microRNAs in the Drosophila circadian clock. [FBrf0209082] Tanaka-Matakatsu et al., 2009, Dev. Biol. 326(2): 347--356 Regulation of apoptosis of rbf mutant cells during Drosophila development. [FBrf0207165] Yang et al., 2009, PLoS Genet. 5(4): e1000444 The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. [FBrf0207703] Jaklevic et al., 2008, Dev. Biol. 320(1): 122--130 Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. [FBrf0207139] Shcherbata et al., 2007, Cell Stem Cell 1(6): 698--709 Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary. [FBrf0202622] Bilen et al., 2006, Mol. Cell 24(1): 157--163 MicroRNA pathways modulate polyglutamine-induced neurodegeneration. [FBrf0192284] Meyer et al., 2006, PLoS Genet. 2(8): e134 Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. [FBrf0194224] Nolo et al., 2006, Curr. Biol. 16(19): 1895--1904 The bantam microRNA is a target of the hippo tumor-suppressor pathway. [FBrf0194704] Thompson and Cohen, 2006, Cell 126(4): 767--774 The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. [FBrf0193861] Resino and Garcia-Bellido, 2004, Mech. Dev. 121(4): 351--364 Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning. [FBrf0174883] Brennecke et al., 2003, Cell 113(1): 25--36 bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. [FBrf0158764] Raisin et al., 2003, Genetics 164(3): 1015--1025 A new genetic locus controlling growth and proliferation in Drosophila melanogaster. [FBrf0160859] Hipfner et al., 2002, Genetics 161(4): 1527--1537 The bantam gene regulates Drosophila growth. [FBrf0152024]

Allele Dmel\banEP3622

Allele Dmel\ban^EP3622