homo- and heterozygous mutants exhibit age-dependent degeneration of the nervous system.
exhibit a mild rough eye phenotype.
mutant third instar larval brains show increased vacuolisation compared to controls. The phenotype is more severe in males than in females. An increased number of vacuoles is also seen in 4 day old adult flies.
Mutants exhibit severe vacuolisation of the central nervous system. The vacuolar pathology is most prominent around the central complex and the central parts of the brain. Neurons appear to undergo necrotic cell death. Mutants also have ~40% reduced levels of cholesterol ester.