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General Information
Symbol
Dmel\Nop60BDL4
Species
D. melanogaster
Name
FlyBase ID
FBal0144707
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nop60BDL4 was generated by Δ2-3 induced imprecise excision of P{lacW}Nop60BDL2011. Approximately 3.5Kb of the P{lacW} insert remains, and no flanking genomic sequence is lost.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Testes from Nop60BDL4 mutants are severely reduced in size compared to wild-type, with little or no evidence of a spermatocyte fusome and a dramatic reduction in the numbers of germ cells, including germ-line stem cells. Somatic cell numbers in the testes are unaffected, although the hub cells are elongated.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Nop60BDL4 homozygotes carrying Nop60Bhs.PG show a dramatic rescue of testicular atrophy, with rescue of branched fusomes and of germ cells. The degree of rescue diminishes with age.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Nop60BDL4
Name Synonyms
Secondary FlyBase IDs
    References (1)