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General Information
Symbol
Dmel\Lrev6-3
Species
D. melanogaster
Name
FlyBase ID
FBal0144763
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lrev6-3 mutant eye clones exhibit a domain specific phenotype. Loss-of-function Lrev6-3 clones in the ventral eye result in the selective loss of eye fate. However, in the dorsal eye these clones have no effect on the eye fate.

Lfee/Lrev6-3 trans-heterozygotes have smaller eyes than Lfee alone.

Lrev6-3 clones in they eye disc show TUNEL-positive cells in the ventral eye (indicating cell death), while cells in the dorsal half of the eye are not affected.

Heterozygotes have normal eyes. Homozygous clones in the eye result in elimination of the ventral eye, but have no effect in the dorsal eye.

Homozygous clones in the dorsal part of the eye do not affect ommatidial development. Homozygous clones in the ventral part of the eye inhibit ommatidial development. Homozygous clones generated during the first larval instar can completely eliminate eye fate in the eye-antennal disc, whereas antennal development in the same disc is unaffected.

Homozygous embryos fail to complete germ band retraction and show no cuticle formation. Homozygous clones in the ventral part of eye disc, induced during the first larval instar, result in a large reduction of the ventral part of the eye disc in the third larval instar, with the surrounding heterozygous tissue and wild-type clonal tissue generally disappearing together with the homozygous clonal tissue. This results in adult eyes in which most of the ventral region of the eye is replaced by the cuticle. Homozygous clones of considerable size in the dorsal part of the eye disc, induced during the first larval instar, do not cause any obvious reduction in size of the dorsal part of the eye disc, and photoreceptor differentiation and polarity appears unaffected by these clones. Homozygous clones induced in ventral or dorsal regions of the eye disc during the late second and the third larval instars do not result in any obvious eye defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Statement
Reference

L[+]/Lrev6-3 is a suppressor of visible | somatic clone phenotype of pnrVX6

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Lrev6-3 has eye | somatic clone phenotype, suppressible by hth[+]/hthMeis1-P2

Lrev6-3 has eye disc | somatic clone phenotype, suppressible by hth[+]/hthMeis1-P2

Lrev6-3 has eye | somatic clone phenotype, suppressible by hth[+]/hth100-1

Lrev6-3 has eye disc | somatic clone phenotype, suppressible by hth[+]/hth100-1

Lrev6-3 has eye | ventral | somatic clone phenotype, suppressible by pnr[+]/pnrVX6

Suppressor of
Statement
Reference

L[+]/Lrev6-3 is a suppressor of eye | dorsal | somatic clone phenotype of pnrVX6

Other
Statement
Reference

Lrev6-3, sgg[+]/sgg1 has eye | ventral phenotype

Additional Comments
Genetic Interactions
Statement
Reference

Lrev6-3 heterozygous eye clones in a hth100-1 or hthMeis1-P2 heterozygous background results in no ventral eye loss and a wild-type eye phenotype.

Expression of either sggS9A.Scer\UAS or panΔN.Scer\UAS, under the control of Scer\GAL4ey.PH, in Lrev6-3 clones suppresses the loss of ventral cells in the eye disc.

sgg1/+ ; Lrev6-3/+ flies show loss of the ventral eye. The dorsal eye enlargements caused by homozygous pnrVX6 clones are no longer seen in the flies are also carrying Lrev6-3/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Revertant. Selected as: a revertant of the LD dominant half eye phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)