FlyBase Allele Report: Dmel\Gp150[k11120b]

General Information

Symbol

Dmel\Gp150^k11120b

Species

D. melanogaster

Name

FlyBase ID

FBal0144851

Feature type

allele

Associated gene

Dmel\Gp150

Associated Insertion(s)

Carried in Construct

Also Known As

gp150²

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)X58-12)

(Kahsai et al., 2016)

lethal (with Gp150³)

(Fetchko et al., 2002)

visible

(Fetchko et al., 2002)

Phenotype Manifest In

anterior scutellar bristle (with Gp150³)

(Fetchko et al., 2002)

eye

(Fetchko et al., 2002)

eye (with Gp150³)

(Fetchko et al., 2002)

eye photoreceptor cell | somatic clone (with Gp150^k11107b)

(Li et al., 2003)

macrochaeta (with Df(2R)Liprin-γ^H1)

(Astigarraga et al., 2010)

ommatidium

(Fetchko et al., 2002)

ommatidium (with Gp150³)

(Fetchko et al., 2002)

ommatidium (with Gp150^P8)

(Fetchko et al., 2002)

ommatidium | somatic clone (with Gp150^k11107b)

(Li et al., 2003)

photoreceptor cell R1 (with Gp150³)

(Fetchko et al., 2002)

photoreceptor cell R6 (with Gp150³)

(Fetchko et al., 2002)

photoreceptor cell R8 (with Gp150³)

(Fetchko et al., 2002)

photoreceptor cell R8 | cell autonomous | somatic clone

(Li et al., 2003)

wing margin bristle

(Fetchko et al., 2002)

wing margin bristle | ectopic

(Fetchko et al., 2002)

wing vein L3 | ectopic

(Fetchko et al., 2002)

Detailed Description

Statement

Reference

In Gp150^k11120b somatic clones, the spacing of the R8 photoreceptors is irregular and extra R8 cells are seen. Defects appear to be cell autonomous. When Gp150^k11120b/Gp150^k11107b clones are made in the eye mutant ommatidia are seen. No specific photoreceptor cell type is found to be mutant at a higher proportion than the others in these clones.

(Li et al., 2003)

35% of ommatidia are mutant in homozygotes. 27% of ommatidia are mutant in Gp150^k11120b/Df(2R)02311 animals. Mutants exhibit a loss of some wing margin bristles and some ectopic bristles are seen in the second and third veins. Also a "delta-like" vein structure is seen at the distal end of wing vein 3. Over 60% of Gp150^k11120b/Gp150³ flies fail to develop to adulthood with most of them dying during pupal development. 2/3 of the anterior scutellars in surviving adults, exhibit no shaft and no socket, 1/4 have double sockets, 3% have one shaft and two sockets and another 3% have two shafts and one socket. 45% of ommatidia are mutant in Gp150^k11120b/Gp150³ animals. Developing ommatidial clusters are often irregularly spaced and the morphogenetic furrow appears broader as the cells within the region are no longer constricted in a narrow stripe. Multiple R8 precursor cells are often closely located, about 10% of ommatidia contain multiple R8 precursors that become R8 cells. Some oversized ommatidia are seen at early stages of ommatidia assembly. Some ommatidia contain additional or fewer R1/R6 cells. 19.2% of ommatidia in Gp150^P8/Gp150^k11120b animals are mutant. 0.19% of ommatidia in Gp150^k11120b/+ animals are mutant.

(Fetchko et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Gp150[+]/Gp150^k11120b is a suppressor of visible | recessive phenotype of N^spl-1

(Li et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Gp150^k11120b/Gp150^P8 has ommatidium phenotype, enhanceable by Delta^6B

(Fetchko et al., 2002)

Gp150^k11120b/Gp150^P8 has ommatidium phenotype, enhanceable by Delta^9P

(Fetchko et al., 2002)

Gp150^k11120b/Gp150^P8 has ommatidium phenotype, enhanceable by N^55e11

(Fetchko et al., 2002)

Gp150^k11120b has ommatidium phenotype, enhanceable by Delta^6B

(Fetchko et al., 2002)

Gp150^k11120b has ommatidium phenotype, enhanceable by Delta^9P

(Fetchko et al., 2002)

Gp150^k11120b has ommatidium phenotype, enhanceable by N^55e11

(Fetchko et al., 2002)

Suppressor of

Statement

Reference

Gp150[+]/Gp150^k11120b is a suppressor of eye phenotype of N^spl-1

(Li et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of N^55e11/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 42.3%. The addition of Dl^9P/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 67.6%. Often rhabdomeres exhibit abnormal morphology. The addition of Dl^6B/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 44.6%. The addition of N^55e11/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 0.65%. The addition of Dl^9P/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 2.7%. The addition of Dl^6B/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 0.18%.