Allele Dmel\Gp150^k11120b

General Information
Symbol	Dmel\Gp150^k11120b	Species	D. melanogaster
Name		FlyBase ID	FBal0144851
Feature type	allele	Associated gene	Dmel\Gp150
Also Known As	gp150²

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal (with Gp150³) (Fetchko et al., 2002) visible (Fetchko et al., 2002)
Phenotype Manifest In
	anterior scutellar bristle (with Gp150³) (Fetchko et al., 2002) eye (Fetchko et al., 2002) eye (with Gp150³) (Fetchko et al., 2002) eye photoreceptor cell \| somatic clone (with Gp150^k11107b) (Li et al., 2003) macrochaeta (with Df(2R)Liprin-γ^H1) (Astigarraga et al., 2010) ommatidium (Fetchko et al., 2002) ommatidium (with Gp150³) (Fetchko et al., 2002) ommatidium (with Gp150^P8) (Fetchko et al., 2002) ommatidium \| somatic clone (with Gp150^k11107b) (Li et al., 2003) photoreceptor cell R1 (with Gp150³) (Fetchko et al., 2002) photoreceptor cell R6 (with Gp150³) (Fetchko et al., 2002) photoreceptor cell R8 (with Gp150³) (Fetchko et al., 2002) photoreceptor cell R8 \| cell autonomous \| somatic clone (Li et al., 2003) wing margin bristle (Fetchko et al., 2002) wing margin bristle \| ectopic (Fetchko et al., 2002) wing vein L3 \| ectopic (Fetchko et al., 2002)
Detailed Description
	Statement Reference In Gp150^k11120b somatic clones, the spacing of the R8 photoreceptors is irregular and extra R8 cells are seen. Defects appear to be cell autonomous. When Gp150^k11120b/Gp150^k11107b clones are made in the eye mutant ommatidia are seen. No specific photoreceptor cell type is found to be mutant at a higher proportion than the others in these clones. (Li et al., 2003) 35% of ommatidia are mutant in homozygotes. 27% of ommatidia are mutant in Gp150^k11120b/Df(2R)02311 animals. Mutants exhibit a loss of some wing margin bristles and some ectopic bristles are seen in the second and third veins. Also a "delta-like" vein structure is seen at the distal end of wing vein 3. Over 60% of Gp150^k11120b/Gp150³ flies fail to develop to adulthood with most of them dying during pupal development. 2/3 of the anterior scutellars in surviving adults, exhibit no shaft and no socket, 1/4 have double sockets, 3% have one shaft and two sockets and another 3% have two shafts and one socket. 45% of ommatidia are mutant in Gp150^k11120b/Gp150³ animals. Developing ommatidial clusters are often irregularly spaced and the morphogenetic furrow appears broader as the cells within the region are no longer constricted in a narrow stripe. Multiple R8 precursor cells are often closely located, about 10% of ommatidia contain multiple R8 precursors that become R8 cells. Some oversized ommatidia are seen at early stages of ommatidia assembly. Some ommatidia contain additional or fewer R1/R6 cells. 19.2% of ommatidia in Gp150^P8/Gp150^k11120b animals are mutant. 0.19% of ommatidia in Gp150^k11120b/+ animals are mutant. (Fetchko et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Gp150[+]/Gp150^k11120b is a suppressor of visible \| recessive phenotype of N^spl-1 (Li et al., 2003)
Phenotype Manifest In
Enhanced by
Statement Reference Gp150^k11120b/Gp150^P8 has ommatidium phenotype, enhanceable by Dl^6B (Fetchko et al., 2002) Gp150^k11120b/Gp150^P8 has ommatidium phenotype, enhanceable by Dl^9P (Fetchko et al., 2002) Gp150^k11120b/Gp150^P8 has ommatidium phenotype, enhanceable by N^55e11 (Fetchko et al., 2002) Gp150^k11120b has ommatidium phenotype, enhanceable by Dl^6B (Fetchko et al., 2002) Gp150^k11120b has ommatidium phenotype, enhanceable by Dl^9P (Fetchko et al., 2002) Gp150^k11120b has ommatidium phenotype, enhanceable by N^55e11 (Fetchko et al., 2002)
Suppressor of
Statement Reference Gp150[+]/Gp150^k11120b is a suppressor of eye phenotype of N^spl-1 (Li et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The addition of N^55e11/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 42.3%. The addition of Dl^9P/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 67.6%. Often rhabdomeres exhibit abnormal morphology. The addition of Dl^6B/+ to Gp150^P8/Gp150^k11120b animals increases the proportion of mutant ommatidia from 19.2% to 44.6%. The addition of N^55e11/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 0.65%. The addition of Dl^9P/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 2.7%. The addition of Dl^6B/+ to Gp150^k11120b/+ animals increases the proportion of mutant ommatidia from 0.19% to 0.18%. (Fetchko et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Gp150^k11120b is rescued by Gp150^GMR.PF (Fetchko et al., 2002)
Comments
Stocks ( 2 )
Bloomington	11015 y¹ w^67c23; P{lacW}l(2)k11120a^k11120a Gp150^k11120b/CyO
Kyoto	111299 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}l(2)k11120a^k11120a Gp150^k11120b /CyO y⁺
Notes on Origin
Discoverer
	Separable from: l(2)k11120a^k11120a. (FlyBase, 1992-)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	defu² (Li et al., 2003) gp150² (Li et al., 2003, Fetchko et al., 2002) Gp150^k11120b (Astigarraga et al., 2010) l(2)k11120 (Fetchko et al., 2002)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Astigarraga et al., 2010, J. Neurosci. 30(46): 15358--15368 Three Drosophila liprins interact to control synapse formation. [FBrf0212351] Li et al., 2003, Development 130(13): 2819--2827 Scabrous and Gp150 are endosomal proteins that regulate Notch activity. [FBrf0161465] Fetchko et al., 2002, EMBO J. 21(5): 1074--1083 Drosophila Gp150 is required for early ommatidial development through modulation of Notch signaling. [FBrf0144849]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Allele Dmel\Gp150k11120b

Allele Dmel\Gp150^k11120b