Allele Dmel\trio^123.4

General Information
Symbol	Dmel\trio^123.4	Species	D. melanogaster
Name		FlyBase ID	FBal0146746
Feature type	allele	Associated gene	Dmel\trio

Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Giniger, 2003.7.28)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	trio^S036810 (Giniger, 2003.7.28)
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (with trio¹) (Song and Giniger, 2011)
Phenotype Manifest In
	intersegmental nerve branch ISNb of A1-7 (with trio¹) (Song and Giniger, 2011)
Detailed Description
	Statement Reference trio[1]/trio[123.4] mutants display a specific axonal defect in ISNb, 'stalling' in the middle of the target field. (Song and Giniger, 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference N^l1N-ts1, trio^123.4/trio[+] has neuroanatomy defective \| heat sensitive phenotype, enhanceable by Scer\GAL4^elav-C155/trio^Scer\UAS.cBa (Song and Giniger, 2011)
Suppressed by
Statement Reference N^l1N-ts1, trio^123.4/trio[+] has neuroanatomy defective \| heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^{GEF1mu.Scer\UAS} (Song and Giniger, 2011)
NOT suppressed by
Statement Reference N^l1N-ts1, trio^123.4/trio[+] has neuroanatomy defective \| heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^{GEF1mu.Scer\UAS} (Song and Giniger, 2011)
Suppressor of
Statement Reference trio^123.4/trio[+] is a suppressor of neuroanatomy defective \| heat sensitive phenotype of N^l1N-ts1 (Song and Giniger, 2011)
Phenotype Manifest In
Enhanced by
Statement Reference N^l1N-ts1, trio^123.4/trio[+] has intersegmental nerve \| heat sensitive phenotype, enhanceable by Scer\GAL4^elav-C155/trio^Scer\UAS.cBa (Song and Giniger, 2011) N^l1N-ts1, trio^123.4/trio[+] has intersegmental nerve branch ISNb of A1-7 \| heat sensitive phenotype, enhanceable by Scer\GAL4^elav-C155/trio^Scer\UAS.cBa (Song and Giniger, 2011)
Suppressed by
Statement Reference N^l1N-ts1, trio^123.4/trio[+] has intersegmental nerve \| heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^{GEF2mu.Scer\UAS} (Song and Giniger, 2011) N^l1N-ts1, trio^123.4/trio[+] has intersegmental nerve branch ISNb of A1-7 \| heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^{GEF2mu.Scer\UAS} (Song and Giniger, 2011) N^l1N-ts1, trio^123.4/trio[+] has segmental nerve branch SNa of A1-7 \| heat sensitive phenotype, suppressible by Scer\GAL4^elav-C155/trio^{GEF2mu.Scer\UAS} (Song and Giniger, 2011)
NOT suppressed by
Statement Reference N^l1N-ts1, trio^123.4/trio[+] has intersegmental nerve \| heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^{GEF1mu.Scer\UAS} (Song and Giniger, 2011) N^l1N-ts1, trio^123.4/trio[+] has intersegmental nerve branch ISNb of A1-7 \| heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^{GEF1mu.Scer\UAS} (Song and Giniger, 2011) N^l1N-ts1, trio^123.4/trio[+] has segmental nerve branch SNa of A1-7 \| heat sensitive phenotype, non-suppressible by Scer\GAL4^elav-C155/trio^{GEF1mu.Scer\UAS} (Song and Giniger, 2011)
Suppressor of
Statement Reference trio^123.4/trio[+] is a suppressor \| partially of intersegmental nerve \| heat sensitive phenotype of N^l1N-ts1 (Crowner et al., 2003) trio^123.4/trio[+] is a suppressor of intersegmental nerve \| heat sensitive phenotype of N^l1N-ts1 (Song and Giniger, 2011) trio^123.4/trio[+] is a suppressor of intersegmental nerve branch ISNb of A1-7 \| heat sensitive phenotype of N^l1N-ts1 (Song and Giniger, 2011)
Additional Comments
Genetic Interactions
Statement Reference A trio[123.4] heterozygous background significantly restores the ability of ISNb axons to enter the ventrolateral muscle field in N[l1N-ts1] mutants. This suppression is reverted upon pan-neural expression of trio[Scer\UAS.cBa] under the control of Scer\GAL4[elav-C155]. Pan-neuronal expression of trio[GEF1mu.Scer\UAS] in a N[l1N-ts1]; trio[123.4]/+ background (under the control of Scer\GAL4[elav-C155]) does not restore the ability of ISNb axons to enter the ventrolateral muscle field. Pan-neuronal expression of trio[GEF2mu.Scer\UAS] in a N[l1N-ts1]; trio[123.4]/+ background (under the control of Scer\GAL4[elav-C155]) restores the ability of ISNb axons to enter the ventrolateral muscle field. (Song and Giniger, 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	trio^123.4 (Song and Giniger, 2011)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Song and Giniger, 2011, Dev. Dyn. 240(2): 324--332 Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio. [FBrf0212819] Crowner et al., 2003, Curr. Biol. 13(11): 967--972 Notch Steers Drosophila ISNb Motor Axons by Regulating the Abl Signaling Pathway. [FBrf0159717]
Personal communication to FlyBase	Giniger, 2003.7.28, UAS-Dl, nrt<up>M54</up>, trio<up>123.4</up> and sim-GAL4. UAS-Dl, nrt^M54, trio^123.4 and sim-GAL4. [FBrf0159722]

Allele Dmel\trio123.4

Allele Dmel\trio^123.4