FB2025_01 , released February 20, 2025
Allele: Dmel\taccTD.UASp.Tag:GST
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General Information
Symbol
Dmel\taccTD.UASp.Tag:GST
Species
D. melanogaster
Name
FlyBase ID
FBal0146763
Feature type
allele
Associated gene
Dmel\tacc
Associated Insertion(s)
Carried in Construct
P{UASp-tacc.GST-TD}
Key Links
Transgenic product class
inframe_deletion
(Lee et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Lee et al., 2001)
Mutagen
in vitro construct
(Lee et al., 2001)
Progenitor genotype
Carried in construct
P{UASp-tacc.GST-TD}
Cytology
Description

UASp regulatory sequences drive expression of the tacc TACC domain tagged with Tag:GST.

(Lee et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
tacc
Tagged with
Tag:GST
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Most embryos expressing taccTD.Scer\UAS.P\T.T:Sjap\GST under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 fail to develop. The embryos are often filled with microtubules that are organised into asters which are centered around aggregates of taccTD.Scer\UAS.P\T.T:Sjap\GST protein.

      (Lee et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Asters of microtubules are not detected in mutant embryos expressing taccTD.Scer\UAS.P\T.T:Sjap\GST under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 in a mspsMJ15 background. The embryos do not develop, but the male and female pronuclei seem to be in a mitotic state, with spindle-like structures organised around the condensed chromosomes.

      (Lee et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      taccTD.Scer\UAS.P\T.T:Sjap\GST
      taccTD.UASp.Tag:GST
      Name Synonyms
      Secondary FlyBase IDs
        References (1)