Insertion 1.2kb upstream of the region coding for the predicted mir-276a precursor.
mir-276aRosa/mir-276aD8 flies show significantly defective naive odour avoidance responses to 4-methylcyclohexanol (1 x 10[-3] v/v) and to 3-octanol (1.5 x 10[-3] v/v), but not to benzaldehyde (0.5 x 10[-3] v/v) compared to wild-type of heterozygous controls.
mir-276aRosa/mir-276aD8 flies show a normal avoidance response to electric shock (60V).
mir-276aRosa/mir-276aA6 and mir-276aRosa/mir-276aD2.2 flies show a normal naive odour avoidance response to 4-methylcyclohexanol (1 x 10[-3] v/v).
Homozygous rosa1 mutant flies do not show any change in sensitivity to ethanol vapor compared to controls.
In memory tests, mutants perform at 96% of wild-type after a single training session, at 63% after spaced training.
mir-276aRosa/mir-276aD8 has abnormal chemosensitive behavior phenotype, suppressible by DopR[+]/Dop1R1f02676
DopRf02676/+ suppresses the defect in naive odour avoidance response to 4-methylcyclohexanol (1 x 10[-3] v/v) which is seen in mir-276aRosa/mir-276aD8 flies.
mir-276aRosa/mir-276aD8 is rescued by mir-276a+tCH321-46B15
mir-276aRosa/mir-276aD8 is not rescued by mir-276atCH322-133G18
mir-276aRosa/mir-276aD8 is not rescued by mir-276atCH322-151H13
mir-276a+tCH321-46B15 rescues the defective naive odour avoidance response to 4-methylcyclohexanol (1 x 10[-3] v/v) which is seen in mir-276aRosa/mir-276aD8 flies.
mir-276atCH322-151H13 fails to rescue the defective naive odour avoidance response to 4-methylcyclohexanol (1 x 10[-3] v/v) which is seen in mir-276aRosa/mir-276aD8 flies.
mir-276atCH322-133G18 fails to rescue the defective naive odour avoidance response to 4-methylcyclohexanol (1 x 10[-3] v/v) which is seen in mir-276aRosa/mir-276aD8 flies.
