FB2025_01 , released February 20, 2025
Allele: Dmel\egrUAS.cIa
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General Information
Symbol
Dmel\egrUAS.cIa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Igaki
FlyBase ID
FBal0147161
Feature type
allele
Associated gene
Dmel\egr
Associated Insertion(s)
Carried in Construct
P{UAS-eiger.I}
Also Known As
UAS-Egr, UAS-eiger, UAS-Eigerw, UAS-EgrW, UAS-Eiger+W
Key Links
Transgenic product class
wild_type
(Igaki et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Igaki et al., 2002)
Mutagen
in vitro construct
(Igaki et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-eiger.I}
Cytology
Description

UASt sequences drive expression of egr.

(Igaki et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
egr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  carcinoma
      CEA
      (Zhang et al., 2019)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by Ras85DV12.UAS, shgk03401
      (Igaki et al., 2006)
      modeled by Ras85DV12.UAS
      (Igaki et al., 2006)
      model of  carcinoma
      is ameliorated by panJF02306
      (Zhang et al., 2019)
      is ameliorated by wgGD5007
      (Zhang et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal cell migration | third instar larval stage, with Scer\GAL4ptc-559.1

      (Zhang et al., 2019)

      abnormal size, with Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      abnormal size | adult stage, with Scer\GAL4GMR.PF

      (Yanku et al., 2018, Pechkovsky et al., 2013)

      abnormal size | adult stage, with Scer\GAL4GMR.PU

      (Ma et al., 2017)

      abnormal size | larval stage, with Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      decreased size | adult stage, with Scer\GAL4GMR.PU

      (Das et al., 2023, Zheng et al., 2023)

      increased cell death, with Scer\GAL4FRT.Act5C

      (Ma et al., 2013)

      increased cell death, with Scer\GAL4GMR.PF

      (Zhang et al., 2015, Yang et al., 2013, Ma et al., 2012)

      increased cell death | larval stage, with Scer\GAL4GMR.PU

      (Das et al., 2023)

      increased cell death | larval stage, with Scer\GAL4ptc.PU

      (Das et al., 2023)

      increased cell death | somatic clone, with Scer\GAL4GMR.PF

      (Igaki et al., 2006)

      lethal - all die before end of larval stage, with Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      lethal - all die before end of P-stage, with Scer\GAL4pnr-MD237

      (Zhang et al., 2010)

      lethal - all die before end of pupal stage, with Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      majority die during P-stage | male limited, with Scer\GAL4ptc.PU

      (Das et al., 2023)

      neoplasia | third instar larval stage, with Scer\GAL4Bx-MS1096

      (Bunker et al., 2015)

      partially lethal - majority die | heat sensitive, with Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      partially lethal - majority live | temperature conditional, with Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      some die during embryonic stage, with Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      some die during pupal stage, with Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      visible, with Scer\GAL4GMR.PF

      (Zhang et al., 2015, Tiwari and Roy, 2009, Arya and Lakhotia, 2008, Xue et al., 2007)

      visible, with Scer\GAL4GMR.PU

      (Chabu and Xu, 2014, Zhang et al., 2010)

      visible, with Scer\GAL4pnr.PU

      (Ma et al., 2014)

      visible, with Scer\GAL4pnr-MD237

      (Xue et al., 2007)

      visible | adult stage, with Scer\GAL4bbg-C96

      (Mok and Choi, 2021)

      visible | adult stage, with Scer\GAL4GMR.PF

      (Yanku et al., 2018, Pechkovsky et al., 2013)

      visible | adult stage, with Scer\GAL4GMR.PU

      (Das et al., 2023, Zheng et al., 2023, Ma et al., 2017)

      visible | adult stage, with Scer\GAL4ptc.PU

      (Das et al., 2023)
      Phenotype Manifest In

      anterior crossvein | absent, with Scer\GAL4ptc.PU

      (Das et al., 2023)

      anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4ptc-559.1

      (Zhang et al., 2019)

      embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4He.PZ

      (Bidla et al., 2007)

      embryonic/larval optic stalk, with Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      embryonic/larval salivary gland | larval stage, with Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      eye, with Scer\GAL4FRT.Act5C

      (Ma et al., 2013)

      eye, with Scer\GAL4GMR.PF

      (Yanku et al., 2018, Zhang et al., 2015, Pechkovsky et al., 2013, Yang et al., 2013, Ma et al., 2012, Mallik and Lakhotia, 2009, Tiwari and Roy, 2009, Arya and Lakhotia, 2008, Xue et al., 2007, Igaki et al., 2002)

      eye, with Scer\GAL4GMR.PU

      (Das et al., 2023, Zheng et al., 2023, Ma et al., 2017, Chabu and Xu, 2014, Zhang et al., 2010)

      eye | somatic clone, with Scer\GAL4GMR.PF

      (Igaki et al., 2006)

      eye-antennal disc, with Scer\GAL4GMR.PU

      (Das et al., 2023)

      eye-antennal disc | somatic clone, with Scer\GAL4Act5C.PI

      (Igaki et al., 2009)

      eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      male genitalia, with Scer\GAL4ptc.PU

      (Das et al., 2023)

      ommatidium, with Scer\GAL4GMR.PU

      (Das et al., 2023)

      scutellar bristle | decreased number, with Scer\GAL4ptc.PU

      (Das et al., 2023)

      scutellum, with Scer\GAL4pnr.PU

      (Ma et al., 2014)

      scutellum, with Scer\GAL4pnr-MD237

      (Xue et al., 2007)

      wing, with Scer\GAL4bbg-C96

      (Mok and Choi, 2021)

      wing, with Scer\GAL4vg.PM

      (Mallik and Lakhotia, 2009)

      wing blade, with Scer\GAL4ptc.PU

      (Das et al., 2023)

      wing disc | third instar larval stage, with Scer\GAL4Bx-MS1096

      (Bunker et al., 2015)

      wing margin, with Scer\GAL4ptc.PU

      (Ma et al., 2012)
      Detailed Description
      Statement
      Reference

      The expression of egrUAS.cIa under the control of Scer\GAL4bbg-C96 (and Dicer-2 for a more efficient RNAi) induces notches along the wing margin.

      (Mok and Choi, 2021)

      Expressing egrUAS.cIa under the control of either Scer\GAL4C587, Scer\GAL4nos.PU, Scer\GAL4upd1.PU does not induce any major L3 spermatogenesis defects.

      (La Marca et al., 2019)

      Expressing egrUAS.cIa at the anterior/posterior boundary of the third instar larval wing disc (under the control of Scer\GAL4ptc-559.1) leads to severe cell migration away from the ptc-positive domain,

      (Zhang et al., 2019)

      Expression of egrUAS.cIa under the control of Scer\GAL4ptc-559.1 results in small, underdeveloped larval salivary glands, as compared to controls.

      Expression of egrUAS.cIa under the control of Scer\GAL4GMR.PF results in a small eye phenotype.

      (Yanku et al., 2018)

      The expression of egrUAS.cIa under the control of Scer\GAL4hh-Gal4 does not lead to any obvious phenotype in the wing disc, as compared to controls.

      (de Vreede et al., 2018)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU results in a small rough eye phenotype in adult flies.

      (Ma et al., 2017)

      The expression of egrScer\UAS.cIa driven by Scer\GAL4Bx-MS1096 leads to tissue disorganization in third instar larval wing discs, without disrupting cell polarity, as compared to controls.

      (Bunker et al., 2015)

      Expression of egrUAS.cIa under the control of Scer\GAL4repo.PL or Scer\GAL4elav.PU in the embryonic ventral nerve cord does not affect the volume of apoptotic particles, compared to controls; in the case of Scer\GAL4elav.PU, the numbers of EVE, DAC and CUT expressing neurons are unaffected, compared to controls; in the case of Scer\GAL4repo.PL, the number of glial cells are unaffected, compared to controls.

      (Shklover et al., 2015)

      Expression of egrScer\UAS.cIa in the developing eye driven by Scer\GAL4GMR.PF triggers massive cell death and produces a small-eye phenotype.

      (Zhang et al., 2015)

      Flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU show a small eye phenotype.

      (Chabu and Xu, 2014)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4pnr.PU produces a small scutellum phenotype.

      (Ma et al., 2014)

      Expression of egrScer\UAS.cIa in the developing eye, under the control of Scer\GAL4Scer\FRT.Act5C, generates a small eye phenotype.

      Ectopic expression of egrScer\UAS.cIa in the wing disc, under the control of Scer\GAL4ptc-559.1 results in cell invasion from the anterior-posterior boundary to the posterior compartment and up-regulation of Mmp1.

      Ectopic expression of egrScer\UAS.cIa driven by Scer\GAL4pnr-MD237 triggers cell death in the notum area of 3rd instar larval wing discs, and generates a small scutellum phenotype.

      Ectopic expression of egrScer\UAS.cIa driven by Scer\GAL4sd-SG29.1 results in extensive cell death in 3rd instar larval wing discs, and loss of wing margin tissue in adults.

      (Ma et al., 2013)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF results in reduced adult eclosion; 81% of adults eclose at 18[o]C, 49% at 24[o]C and 38% at 29[o]C.

      The eyes of flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF at 18[o]C are reduced to 13% of the size of controls in females and 26% in males.

      (Pechkovsky et al., 2013)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4hs.2sev does not affect eye morphology.

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF results in a substantially smaller adult eye.

      (Yang et al., 2013)

      Expression of egrScer\UAS.cIa in the developing eye under the control of Scer\GAL4GMR.PF induces cell death and a small eye phenotype.

      Ectopic expression of egrScer\UAS.cIa along the anterior posterior compartment boundary of the wing disc (under the control of Scer\GAL4ptc.PU), produces a notch phenotype in the adult wing margin.

      (Ma et al., 2012)

      Ectopic expression of egrScer\UAS.cIa under the control of Scer\GAL4pnr-MD237 causes pupal stage lethality.

      Ectopic expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU leads to a small-eye phenotype.

      (Zhang et al., 2010)

      Expression of egrScer\UAS.cIa in the eye under the control of Scer\GAL4GMR.PF does not result in any morphological defects.

      Expression of egrScer\UAS.cIa in 20 % reduction in average clone size compared to wild-type somatic clones.

      (Igaki et al., 2009)

      Scer\GAL4GMR.PF-driven expression of egrScer\UAS.cIa results in almost complete loss of the eye and lethality of 36% of differentiated pupae.

      Scer\GAL4GMR.PF-driven expression of egrScer\UAS.cIa results in a reduction and abnormal arrangement of photoreceptor cells in eye discs.

      Scer\GAL4GMR.PF-driven expression of egrScer\UAS.cIa leads to disarrayed axonal projections in the optic stalk of eye discs.

      Scer\GAL4vg.PM-mediated expression of egrScer\UAS.cIa leads to formation of reduced and vestigial wings.

      (Mallik and Lakhotia, 2009)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF results in a small eye phenotype.

      (Tiwari and Roy, 2009)

      Expression of egrScer\UAS.cIa in hemocytes under the control of Scer\GAL4He.PZ is sufficient to induce melanization. Expression of egrScer\UAS.cIa in the fat-body under the control of Scer\GAL4Lsp2.PH is not sufficient to induce melanization.

      (Bidla et al., 2007)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF results in a small-eye phenotype.

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4pnr-MD237 at 18[o]C results in a small scutellum compared to wild type.

      (Xue et al., 2007)

      Overexpression of egrScer\UAS.cIa in eye clones, under the control of Scer\GAL4GMR.PF results in a severe eye phenotype with apparently massive levels of apoptosis.

      (Igaki et al., 2006)

      Expression of egrScer\UAS.cIa when driven by Scer\GAL4GMR.PF causes a severe reduced eye phenotype.

      (Igaki et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PU, egrUAS.cIa has increased cell death | larval stage phenotype, enhanceable by spoonUAS.Tag:HA/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by spoonUAS.Tag:HA/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has decreased size | adult stage phenotype, enhanceable by spoonUAS.Tag:HA/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has decreased size | adult stage phenotype, enhanceable by Ire1UAS.Tag:V5/Scer\GAL4Act.PU

      (Zheng et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by Ire1UAS.Tag:V5/Scer\GAL4Act.PU

      (Zheng et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has decreased size | adult stage phenotype, enhanceable by Scer\GAL4Act.PU/Xbp1UAS.s.Tag:V5

      (Zheng et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by Scer\GAL4Act.PU/Xbp1UAS.s.Tag:V5

      (Zheng et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has abnormal size | adult stage phenotype, enhanceable by fmtGD6928/Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by fmtGD6928/Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has abnormal size | adult stage phenotype, enhanceable by PpVGD7532, Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by PpVGD7532, Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has abnormal size | adult stage phenotype, enhanceable by fmt[+]/fmt1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by fmt[+]/fmt1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has abnormal size | adult stage phenotype, enhanceable by PpV[+]/PpVΔ1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by PpV[+]/PpVΔ1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has abnormal size | adult stage phenotype, enhanceable by PpV[+]/fmt[+]/PpVΔ1/fmt1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, enhanceable by PpV[+]/fmt[+]/PpVΔ1/fmt1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has visible phenotype, enhanceable by TaceGD572/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has visible phenotype, enhanceable by TaceRNAi.UAS.cSa/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, enhanceable by MarfJF01650, Scer\GAL4GMR.PF

      (Yang et al., 2013)
      NOT Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PU, egrUAS.cIa has increased cell death | larval stage phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has decreased size | adult stage phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has increased cell death | larval stage phenotype, suppressible | partially by spoonGL00644/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, suppressible | partially by spoonGL00644/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has decreased size | adult stage phenotype, suppressible | partially by spoonGL00644/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has visible | adult stage phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has increased cell death | larval stage phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has increased mortality during development | male limited phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc-559.1, egrUAS.cIa has abnormal cell migration | third instar larval stage phenotype, suppressible | partially by Scer\GAL4ptc-559.1/wgGD5007

      (Zhang et al., 2019)

      Scer\GAL4ptc-559.1, egrUAS.cIa has abnormal cell migration | third instar larval stage phenotype, suppressible | partially by panGD1506/Scer\GAL4ptc-559.1

      (Zhang et al., 2019)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size | adult stage phenotype, suppressible by HUWE1EY01689, Scer\GAL4GMR.PF

      (Yanku et al., 2018)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible | adult stage phenotype, suppressible by HUWE1EY01689, Scer\GAL4GMR.PF

      (Yanku et al., 2018)

      Scer\GAL4ptc-559.1, egrUAS.cIa has abnormal size | larval stage phenotype, suppressible by HUWE1EY01689, Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      Scer\GAL4ptc-559.1, egrUAS.cIa has increased mortality during development phenotype, suppressible | partially by HUWE1EY01689, Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      Scer\GAL4GMR.PU, egrUAS.cIa has abnormal size | adult stage phenotype, suppressible | partially by fmtUAS.cMa/PpVUASp.N.EGFP, Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible | adult stage phenotype, suppressible | partially by fmtUAS.cMa/PpVUASp.N.EGFP, Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by wgSp-1/wg[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by wgSp-1/wg[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by wg[+]/wgl-17

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by wg[+]/wgl-17

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by wgNIG.4889R/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by wgNIG.4889R/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by dsh[+]/dsh6

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by dsh[+]/dsh6

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by arm1/arm[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by arm1/arm[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by pan[+]/pan13a

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by pan[+]/pan13a

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by dshRNAi.UAS.cUa/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by dshRNAi.UAS.cUa/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by panVDRC.cUa/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by panVDRC.cUa/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by sggEP1576/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by sggEP1576/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by Apc2UAS.cUa, Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by Apc2UAS.cUa, Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by bsk1/bsk[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by bsk1/bsk[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size phenotype, suppressible by bskDN.UAS/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by bskDN.UAS/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible by TaceGD572/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible by TaceRNAi.UAS.cSa/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible | partially by Df(1)HA92/+

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible | partially by Df(1)benCO1/+

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible | partially by Df(1)benCO2/+

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible | partially by ben[+]/ben1

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible by benGD1387/Scer\GAL4GMR.PU

      (Ma et al., 2014)

      Scer\GAL4pnr.PU, egrUAS.cIa has visible phenotype, suppressible | partially by benGD1387/Scer\GAL4pnr.PU

      (Ma et al., 2014)

      Scer\GAL4pnr.PU, egrUAS.cIa has visible phenotype, suppressible by ben1

      (Ma et al., 2014)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has increased cell death phenotype, suppressible | partially by Df(3L)Exel6104/+

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has increased cell death phenotype, suppressible | partially by Df(3L)Exel6105/+

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has increased cell death phenotype, suppressible | partially by Uev1A[+]/Uev1ADG14805

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has increased cell death phenotype, suppressible by Df(3L)Exel6105/Df(3L)Exel6104

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has increased cell death phenotype, suppressible by Df(3L)Exel6104/Uev1ADG14805

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has increased cell death phenotype, suppressible | partially by Scer\GAL4FRT.Act5C/Uev1AGD6650

      (Ma et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has partially lethal - majority die | heat sensitive phenotype, suppressible by HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has partially lethal - majority live | temperature conditional phenotype, suppressible by HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible | adult stage phenotype, suppressible by HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has abnormal size | adult stage phenotype, suppressible by HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by CatUAS.cAa, Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by GtpxUAS.cMa, Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by wal[+]/wal02516

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Df(3L)vin5

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Df(2L)cact-255rv64

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Cyt-c-dbln1/Cyt-c-d[+]

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by walHMS01263/Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Df(3L)H99

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Df(2R)Exel7153

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Df(2R)BSC337

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by nopo5-SZ-3004

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Scer\GAL4GMR.PF/nopoGD11550

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Diap1UAS.cHa, Scer\GAL4GMR.PF

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by DroncC318G.UAS, Scer\GAL4GMR.PF

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Traf6ex1

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by Tak11

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by bskDN.UAS/Scer\GAL4GMR.PF

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has increased cell death phenotype, suppressible by pucUAS.cMa/Scer\GAL4GMR.PF

      (Ma et al., 2012)

      Scer\GAL4pnr-MD237, egrUAS.cIa has lethal - all die before end of P-stage phenotype, suppressible | partially by POSHGD11467, Scer\GAL4pnr-MD237

      (Zhang et al., 2010)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible by POSHGD11467, Scer\GAL4GMR.PU

      (Zhang et al., 2010)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible | partially by POSHp327/POSH[+]

      (Zhang et al., 2010)

      Scer\GAL4GMR.PU, egrUAS.cIa has visible phenotype, suppressible | partially by POSHUAS.cSa, Scer\GAL4GMR.PU

      (Zhang et al., 2010)

      Scer\GAL4GMR.PF, egrUAS.cIa has lethal | pupal stage phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by Hsp60DRNAi.Sym.UAS, Scer\GAL4GMR.PF

      (Arya and Lakhotia, 2008)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by CYLDmr4/CYLD[+]

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by CYLDmr4/CYLDmr4

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by Traf6[+]/Traf6ex1

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by Traf6ex1/Traf6ex1

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has visible phenotype, suppressible by Scer\GAL4GMR.PF/Traf6RNAi.UAS

      (Xue et al., 2007)
      NOT suppressed by
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      egrUAS.cIa, Scer\GAL4GMR.PU is a non-suppressor of visible phenotype of POSHUAS.cSa, Scer\GAL4GMR.PU

      (Zhang et al., 2010)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PU, egrUAS.cIa has eye-antennal disc phenotype, enhanceable by spoonUAS.Tag:HA/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by spoonUAS.Tag:HA/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has ommatidium phenotype, enhanceable by spoonUAS.Tag:HA/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by Ire1UAS.Tag:V5/Scer\GAL4Act.PU

      (Zheng et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by Scer\GAL4Act.PU/Xbp1UAS.s.Tag:V5

      (Zheng et al., 2023)

      Scer\GAL4bbg-C96, egrUAS.cIa has wing phenotype, enhanceable by Mnat9KK109382, Scer\GAL4bbg-C96

      (Mok and Choi, 2021)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by fmtGD6928/Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by PpVGD7532, Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by fmt[+]/fmt1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by PpV[+]/PpVΔ1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, enhanceable by PpV[+]/fmt[+]/PpVΔ1/fmt1

      (Ma et al., 2017)

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has eye phenotype, enhanceable by TaceGD572/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, bskDN.UAS, egrUAS.cIa has eye phenotype, enhanceable by TaceRNAi.UAS.cSa/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, enhanceable by MarfJF01650, Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, enhanceable by Rab5UAS.cEa, Scer\GAL4GMR.PF

      (Igaki et al., 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has embryonic/larval optic stalk phenotype, enhanceable by lncRNA:HsrωEP3037/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, enhanceable by Diap1RNAi.UAS.cLa, Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, enhanceable by pucE69/puc[+]

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, enhanceable by Scer\GAL4GMR.PF/lncRNA:HsrωEP93D

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, enhanceable by lncRNA:HsrωEP3037/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye photoreceptor cell | third instar larval stage phenotype, enhanceable by lncRNA:HsrωEP3037/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PU, egrUAS.cIa has eye-antennal disc phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has ommatidium phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye-antennal disc phenotype, suppressible | partially by spoonGL00644/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by spoonGL00644/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4GMR.PU, egrUAS.cIa has ommatidium phenotype, suppressible | partially by spoonGL00644/Scer\GAL4GMR.PU

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has wing blade phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has anterior crossvein | absent phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has scutellar bristle | decreased number phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc.PU, egrUAS.cIa has male genitalia phenotype, suppressible | partially by spoonKG02745

      (Das et al., 2023)

      Scer\GAL4ptc-559.1, egrUAS.cIa has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by Scer\GAL4ptc-559.1/wgGD5007

      (Zhang et al., 2019)

      Scer\GAL4ptc-559.1, egrUAS.cIa has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by panGD1506/Scer\GAL4ptc-559.1

      (Zhang et al., 2019)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by HUWE1EY01689, Scer\GAL4GMR.PF

      (Yanku et al., 2018)

      Scer\GAL4ptc-559.1, egrUAS.cIa has embryonic/larval salivary gland | larval stage phenotype, suppressible by HUWE1EY01689, Scer\GAL4ptc-559.1

      (Yanku et al., 2018)

      FBal0293990:, Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by fmtUAS.cMa/PpVUASp.N.EGFP/PpVUASp.N.EGFP, Scer\GAL4GMR.PU

      (Ma et al., 2017)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by bskDN.UAS/Scer\GAL4GMR.PF

      (Zhang et al., 2015, Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by wgSp-1/wg[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by wg[+]/wgl-17

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by wgNIG.4889R/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by dsh[+]/dsh6

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by arm1/arm[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by pan[+]/pan13a

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by dshRNAi.UAS.cUa/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by panVDRC.cUa/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by sggEP1576/Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Apc2UAS.cUa, Scer\GAL4GMR.PF

      (Zhang et al., 2015)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by bsk1/bsk[+]

      (Zhang et al., 2015)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible by TaceGD572/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible by TaceRNAi.UAS.cSa/Scer\GAL4GMR.PU

      (Chabu and Xu, 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by Df(1)HA92/+

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by Df(1)benCO1/+

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by Df(1)benCO2/+

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by ben[+]/ben1

      (Ma et al., 2014)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible by benGD1387/Scer\GAL4GMR.PU

      (Ma et al., 2014)

      Scer\GAL4pnr.PU, egrUAS.cIa has scutellum phenotype, suppressible | partially by benGD1387/Scer\GAL4pnr.PU

      (Ma et al., 2014)

      Scer\GAL4pnr.PU, egrUAS.cIa has scutellum phenotype, suppressible by ben1

      (Ma et al., 2014)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has eye phenotype, suppressible | partially by Df(3L)Exel6104/+

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has eye phenotype, suppressible | partially by Df(3L)Exel6105/+

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has eye phenotype, suppressible | partially by Uev1A[+]/Uev1ADG14805

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has eye phenotype, suppressible by Df(3L)Exel6105/Df(3L)Exel6104

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has eye phenotype, suppressible by Df(3L)Exel6104/Uev1ADG14805

      (Ma et al., 2013)

      Scer\GAL4FRT.Act5C, egrUAS.cIa has eye phenotype, suppressible by Uev1AGD6650/Scer\GAL4GMR.PF

      (Ma et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by HAdV-C\E4orf4UAS.cPa, Scer\GAL4GMR.PF

      (Pechkovsky et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by walHMS01263/Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by CatUAS.cAa, Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by GtpxUAS.cMa, Scer\GAL4GMR.PF

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Df(3L)vin5

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Df(2L)cact-255rv64

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Cyt-c-dbln1/Cyt-c-d[+]

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by wal[+]/wal02516

      (Yang et al., 2013)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Df(3L)H99

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Df(2R)Exel7153

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Df(2R)BSC337

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by nopo5-SZ-3004

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Scer\GAL4GMR.PF/nopoGD11550

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by DroncC318G.UAS, Scer\GAL4GMR.PF

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Traf6ex1

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Tak11

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by pucUAS.cMa/Scer\GAL4GMR.PF

      (Ma et al., 2012)

      Scer\GAL4ptc.PU, egrUAS.cIa has wing margin phenotype, suppressible by nopoGD11550/Scer\GAL4ptc.PU

      (Ma et al., 2012)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Diap1UAS.cHa, Scer\GAL4GMR.PF

      (Ma et al., 2012, Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible by POSHGD11467, Scer\GAL4GMR.PU

      (Zhang et al., 2010)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by POSHp327/POSH[+]

      (Zhang et al., 2010)

      Scer\GAL4GMR.PU, egrUAS.cIa has eye phenotype, suppressible | partially by POSHUAS.cSa, Scer\GAL4GMR.PU

      (Zhang et al., 2010)

      Scer\GAL4GMR.PF, egrUAS.cIa, pucE69/puc[+] has eye phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Diap1UAS.cHa, Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS, Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4vg.PM, egrUAS.cIa has wing phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS/Scer\GAL4vg.PM

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye photoreceptor cell | third instar larval stage phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has embryonic/larval optic stalk phenotype, suppressible by lncRNA:HsrωRNAi.Sym.UAS/Scer\GAL4GMR.PF

      (Mallik and Lakhotia, 2009)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Hsp60DRNAi.Sym.UAS, Scer\GAL4GMR.PF

      (Arya and Lakhotia, 2008)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by CYLDmr4/CYLD[+]

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by CYLDmr4/CYLDmr4

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Traf6[+]/Traf6ex1

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Traf6ex1/Traf6ex1

      (Xue et al., 2007)

      Scer\GAL4GMR.PF, egrUAS.cIa has eye phenotype, suppressible by Scer\GAL4GMR.PF/Traf6RNAi.UAS

      (Xue et al., 2007)
      NOT suppressed by
      Enhancer of
      Suppressor of
      Statement
      Reference

      egrUAS.cIa/Scer\GAL4Act5C.PI is a suppressor of eye-antennal disc | somatic clone phenotype of scrib1

      (Igaki et al., 2009)

      egrUAS.cIa/Scer\GAL4Act5C.PI is a suppressor of eye | somatic clone phenotype of scrib1

      (Igaki et al., 2009)
      NOT Suppressor of
      Statement
      Reference

      egrUAS.cIa, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of POSHUAS.cSa, Scer\GAL4GMR.PU

      (Zhang et al., 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small rough eye phenotype characteristic for adult flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU is enhanced by co-expression of either fmtGD6928 or PpVGD7532 or by combination with a single copy of fmt1 or PpVΔ1, when combined with one copy of both fmt1 and PpVΔ1 the eye is almost completely lost.

      The reduced eye size of Scer\GAL4GMR.PU>egrScer\UAS.cIa adults is not suppressed by co-expressing either fmtScer\UAS.cMa or PpVScer\UAS.P\T.N.T:Avic\GFP-EGFP individually but simultaneous expression of both transgenes significantly ameliorates the small eye phenotype.

      (Ma et al., 2017)

      Expression of TaceGD572 suppresses the small eye phenotype seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4GMR.PU.

      Expression of TacedsRNA.Scer\UAS suppresses the small eye phenotype seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4GMR.PU.

      Co-expression of egrScer\UAS.cIa and bskDN.Scer\UAS under the control of Scer\GAL4GMR.PU results in a moderate hanging eye phenotype.

      Expression of TaceGD572 enhances the hanging eye phenotype seen when egrScer\UAS.cIa and bskDN.Scer\UAS are co-expressed under the control of Scer\GAL4GMR.PU. The majority of these triple mutant animals die in late pupal stages and show a ring of necrotic tissue around the eyes.

      Expression of TacedsRNA.Scer\UAS enhances the hanging eye phenotype seen when egrScer\UAS.cIa and bskDN.Scer\UAS are co-expressed under the control of Scer\GAL4GMR.PU. The majority of these triple mutant animals die in late pupal stages and show a ring of necrotic tissue around the eyes.

      (Chabu and Xu, 2014)

      One copy of any of Df(1)HA92, Df(1)benCO1 or Df(1)benCO2 partially suppresses the small eye phenotype seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4GMR.PU.

      One copy of ben1 partially suppresses the small eye phenotype seen in females expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU. ben1/Y fully suppresses the small eye phenotype. This suppression is reverted upon expression of ben+t6.

      Expression of benGD1387 strongly suppresses the small eye phenotype seen in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PU. This suppression is partially reverted upon expression of either ben+t6, benEP1651 or bend09936.

      Expression of benGD1387 strongly suppresses the scutellum phenotype seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4pnr.PU.

      ben1/Y fully suppresses the scutellum phenotype seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4pnr.PU.

      (Ma et al., 2014)

      Cell death posterior to the eye morphogenetic furrow, triggered by egrScer\UAS.cIa expression under the control of Scer\GAL4Scer\FRT.Act5C is suppressed by expression of Uev1AGD6650.

      Co-expression of Uev1AGD6650 significantly suppresses the cell death increase and small scutellum phenotype found in 3rd instar larval wing discs expressing egrScer\UAS.cIa under the control of Scer\GAL4pnr-MD237.

      Co-expression of Uev1AGD6650 significantly suppresses the extensive cell death in 3rd instar larval wing discs, and loss of wing margin tissue in adults expressing egrScer\UAS.cIa under the control of Scer\GAL4pnr-MD237.

      (Ma et al., 2013)

      Chelating ROS by overexpression of CatScer\UAS.cAa or PHGPxScer\UAS.cMa strongly suppresses egrScer\UAS.cIa-mediated cell death.

      A wal02516/+ background suppresses the small eye phenotype found upon expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A Df(3L)vin5/+ background suppresses the small eye phenotype found upon expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A Df(2L)cact-255rv64/+ background suppresses the small eye phenotype found upon expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A Cyt-c-dbln1/+ background suppresses the small eye phenotype found upon expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      Co-expression of MarfJF01650 enhances the small eye phenotype found upon expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      Co-expression of walHMS01263 partially suppresses the small eye phenotype found upon expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      (Yang et al., 2013)

      A Df(3L)H99 background suppresses the small eye phenotype in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A Df(2R)Exel7153 background mildly suppresses the small eye phenotype in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A Df(2R)BSC337 background mildly suppresses the small eye phenotype in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A Df(2R)ED3485 background fails to suppress the small eye phenotype in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      A nopo5-SZ-3004 mutant background partially suppresses the small eye phenotype found in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      Co-expression of nopoGD11550 partially suppresses the small eye phenotype found in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      Co-expression of nopoGD11550 fully suppresses the adult wing notch phenotype found in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4ptc.PU.

      Expression of thScer\UAS.cHa suppresses the small eye phenotype in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      Expression of NcC318G.Scer\UAS suppresses the small eye phenotype in flies expressing egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      egrScer\UAS.cIa-induced cell death is partially suppressed in hemizygous Traf6ex1 or Tak11 mutant males.

      egrScer\UAS.cIa-induced cell death is partially suppressed by co-expression of bskDN.Scer\UAS or pucScer\UAS.cMa, under the control of Scer\GAL4GMR.PF.

      (Ma et al., 2012)

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4Act.PU in the cells surrounding scrib1 clones in the eye-antennal disc significantly enhances the elimination of the mutant scrib1 clones compared to that seen when the cells surrounding the clone are wild type.

      In an egr1 mutant background, scrib1 mutant clones in the eye-antennal disc are no longer eliminated, but grow aggressively and develop into tumours. In this background, expression of egrScer\UAS.cIa under the control of Scer\GAL4Act.PU only in the cells surrounding the scrib1 clones reverses the tumour phenotype; the scrib1 clones do not overgrow and are out-competed by the surrounding cells.

      (Ohsawa et al., 2011)

      The pupal lethality of Scer\GAL4pnr-MD237>egrScer\UAS.cIa is partially suppressed by the co-expression of POSHGD11467. The flies survive to adulthood with a thorax cleft.

      Co-expression of POSHGD11467 significantly suppresses the Scer\GAL4GMR.PU>egrScer\UAS.cIa-induced small-eye phenotype.

      Heterozygous POSHp327 can suppress the Scer\GAL4GMR.PU>egrScer\UAS.cIa eye phenotype by 37%.

      Overexpression of POSHScer\UAS.cSa can suppress the small-eye phenotype of Scer\GAL4GMR.PU>egrScer\UAS.cIa, although a rough-eye phenotype is still observed.

      (Zhang et al., 2010)

      Expression of egrScer\UAS.cIa and Rab5Scer\UAS.cEa in the eye under the control of Scer\GAL4GMR.PF results in a severe small-eye phenotype.

      Tumour formation and animal lethality are both completely rescued by over-expression of egrScer\UAS.cIa under the control of Scer\GAL4Act5C.PI in scrib1, egr1 double mutant clones.

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4Act5C.PI in scrib1 somatic mutant clones results in a reduction in the size of the clones by 86.5%, and mutant clones are not evident in adult eyes.

      (Igaki et al., 2009)

      Co-expression of P{Sym-UAS-Hsrω} restores ommatidial integrity of Scer\GAL4GMR.PF, egrScer\UAS.cIa almost to wild type, and also substantially reduces the mortality of differentiated pupae.

      Coexpression of HsrωEP93D or HsrωEP3037 enhances the Scer\GAL4GMR.PF, egrScer\UAS.cIa eye phenotype, leading to severe head malformations and the formation of black lesions on the eye, though pupal lethality is not increased.

      Introduction of a single copy of pucE69 into the Scer\GAL4GMR.PF, egrScer\UAS.cIa background dramatically enhances the reduced eye phenotype, with flies displaying a prominent black lesion in place of the eye.

      Co-expression of P{Sym-UAS-Hsrω} strongly suppresses the severe eye degeneration in Scer\GAL4GMR.PF, egrScer\UAS.cIa, pucE69/+ flies, restoring ommatidial integrity and eye size to almost that of wild type.

      Co-expression of P{Sym-UAS-Hsrω} suppresses, while co-expression of HsrωEP3037 enhances the photoreceptor degeneration phenotype seen in Scer\GAL4GMR.PF, egrScer\UAS.cIa eye discs.

      Co-expression of thScer\UAS.cHa suppresses, while co-expression of thdsRNA.Scer\UAS.cLa enhances the eye phenotype of Scer\GAL4GMR.PF, egrScer\UAS.cIa flies.

      Additional co-expression of P{Sym-UAS-Hsrω} in Scer\GAL4GMR.PF, egrScer\UAS.cIa, thScer\UAS.cHa flies restores eyes to wild type. However, additional co-expression of P{Sym-UAS-Hsrω} in Scer\GAL4GMR.PF, egrScer\UAS.cIa, thdsRNA.Scer\UAS.cLa flies fails to rescue the eye phenotype.

      Co-expression of P{Sym-UAS-Hsrω} suppresses, while co-expression of HsrωEP3037 enhances the optic stalk axonal projection phenotype seen in Scer\GAL4GMR.PF, egrScer\UAS.cIa eye discs.

      Co-expression of P{Sym-UAS-Hsrω} restores wing morphology to Scer\GAL4vg.PM, egrScer\UAS.cIa wings such that they are indistinguishable from wild type.

      (Mallik and Lakhotia, 2009)

      The reduced eye phenotype caused by expression of Rab11N124I.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by co-expression of egrScer\UAS.cIa.

      (Tiwari and Roy, 2009)

      Co-expression of Hsp60DdsRNA.Sym.Scer\UAS suppresses the eye phenotype caused by expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF.

      (Arya and Lakhotia, 2008)

      The small-eye phenotype caused by expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF is partially suppressed by one copy of CYLDmr4 (animals heterozygous for Df(2L)CYLDmr4 and carrying P{LX107} to rescue the function of CG13138 and nmd) and is almost completely suppressed by homozygosity for CYLDmr4 (animals homozygous for Df(2L)CYLDmr4 and carrying P{LX107}).

      The small-eye phenotype caused by expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF is not suppressed by Traf4ex1/+ or by co-expression of Traf4dsRNA.Scer\UAS.

      The small-eye phenotype caused by expression of egrScer\UAS.cIa under the control of Scer\GAL4GMR.PF is strongly suppressed by Traf6ex1/+ or by co-expression of Traf6dsRNA.Scer\UAS and is completely suppressed by Traf6ex1/Traf6ex1.

      (Xue et al., 2007)

      Co-expression of bskdsRNA.Scer\UAS with egrScer\UAS.cIa in eye clones, under the control of Scer\GAL4GMR.PF results in suppression of the apoptotic eye phenotype observed in egrScer\UAS.cIa mutant clones.

      Overexpression of egrScer\UAS.cIa in Ras85DV12.Scer\UAS mutants (both under the control of Scer\GAL4Act5C.PI) using the FLP/FRT system in brain somatic clones results in accelerated tumour growth, despite nether expression of Ras85DV12.Scer\UAS or egrScer\UAS.cIa alone causing dramatic overgrowth. These tumorigenic regions do not invade into the ventral nerve cord.

      shgk03401 mutant larval brain cells expressing both Ras85DV12.Scer\UAS and egrScer\UAS.cIa under the control of Scer\GAL4Act5C.PI generate into invasive tumours that can invade the ventral nerve cord (this phenotype occurs with 88% penetrance).

      Expression of Ras85DV12.Scer\UAS, egrScer\UAS.cIa and bskDN.Scer\UAS, under the control of Scer\GAL4Act5C.PI in shgk03401 mutant larval cephalic complexes (brain, eye and antennal discs) induces tumor invasion of the ventral nerve cord.

      (Igaki et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Zzzz\E4orf4Scer\UAS.cPa suppresses the lethality seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4GMR.PF; 99% of adults eclose at 18[o]C, 100% at 24[o]C and 94% at 29[o]C.

      Expression of Zzzz\E4orf4Scer\UAS.cPa partially suppresses the reduction in eye size seen when egrScer\UAS.cIa is expressed under the control of Scer\GAL4GMR.PF at 18[o]C. Eye size is increased to 39% in females (from 13%) and 53% in males (from 26%).

      (Pechkovsky et al., 2013)

      Overexpression of egrScer\UAS.cIa in necrotic Scer\GAL4hs.2sev->Mmus\Gria1Lc.Scer\UAS neurons enhances the eye size defect seen upon expression of Mmus\Gria1Lc.Scer\UAS alone.

      (Yang et al., 2013)
      Complementation and Rescue Data
      Rescues

      egrUAS.cIa/Scer\GAL4He.PZ rescues egr1

      (Bidla et al., 2007)
      Comments

      Expression of egrScer\UAS.cIa under the control of Scer\GAL4He.PZ in a egr1 homozygous mutant background restores melanization levels in hemolymph clots to above wild-type levels.

      (Bidla et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      egrScer\UAS.cIa
      egrUAS.cIa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Igaki
      (Igaki et al., 2002)
      Secondary FlyBase IDs
        References (45)