FlyBase Allele Report: Dmel\egr[3]

General Information

Symbol

Dmel\egr³

Species

D. melanogaster

Name

FlyBase ID

FBal0147163

Feature type

allele

Associated gene

Dmel\egr

Associated Insertion(s)

Carried in Construct

Also Known As

eiger³, egr^3AG

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Igaki et al., 2002)

Progenitor genotype

egr^GS9830

(Igaki et al., 2002)

Cytology

Description

Deletion of approximately 15.kb of egr genomic sequences.

(Tortoriello et al., 2009)

Imprecise excision of the P{GS} element from egr^GS9830 causes a deletion that removes the first coding exon of the egr gene.

(Igaki et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by dlg1^A40.2

(Parvy et al., 2019)

modeled by scrib¹

(Parvy et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell death | adult stage | nutrition conditional

(Etchegaray et al., 2012)

abnormal feeding behavior (with egr¹)

(Mabery and Schneider, 2010)

abnormal immune response

(Berkey et al., 2009, Geuking et al., 2009, Brandt et al., 2004)

abnormal immune response | adult stage (with egr¹)

(Bastos et al., 2017)

viable

(Igaki et al., 2002)

Phenotype Manifest In

egg chamber | nutrition conditional

(Etchegaray et al., 2012)

embryonic/larval hemolymph | third instar larval stage

(Bidla et al., 2007)

follicle cell | nutrition conditional

(Etchegaray et al., 2012)

Detailed Description

Statement

Reference

egr³ homozygotes show apparently normal L3 male gonads.

(La Marca et al., 2019)

egr¹/egr³ mutant adult flies exhibit reduced susceptibility to Coxiella burnetii: their post-infection survival rate is significantly increased compared to wild-type controls.

(Bastos et al., 2017)

Follicle cells from egr³ mutant starved-induced degenerating egg chambers fail to enlarge and take up nurse cell debris, dying prematurely. Excessive follicle cell death is seen in late phases of degeneration after the engulfment defects are apparent. Many mid-stage egg chambers remain healthy under starvation conditions, and these do not show follicle cell death.

(Etchegaray et al., 2012)

egr¹/egr³ transheterozygous flies exhibit severely reduced feeding rates compared to wild-type.

(Mabery and Schneider, 2010)

Homozygous flies are resistant to V. cholerae infection compared to controls.

(Berkey et al., 2009)

egr³ mutant flies show a slight increased susceptibility to challenge by Staphylococcus aureus or Enterococcus faecalis compared to wild type flies.

(Geuking et al., 2009)

Hemolymph clots from egr³ homozygous third instar larvae show reduced levels of melanization.

(Bidla et al., 2007)

When mutant animals are infected by S.typhimurium, the mean time to death is lengthened by 3 days compared to wild-type animals.

(Brandt et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

egr³/egr³ is a suppressor | partially of abnormal size | recessive | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

egr¹/egr³ is a suppressor of neoplasia phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹

(Andersen et al., 2015)

egr³/egr³ is a suppressor of increased cell number | larval stage phenotype of scrib¹

(Parisi et al., 2014)

egr¹/egr³ is a suppressor | partially of increased cell death | somatic clone | third instar larval stage phenotype of Rok^CAT.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

egr¹/egr³ is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of scrib¹

(Khoo et al., 2013)

NOT Suppressor of

Statement

Reference

egr¹/egr³ is a non-suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, Syx7^GD2767

(Andersen et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

egr³/egr[+] is a suppressor of embryonic/larval fat body | larval stage phenotype of Noc1^JF02014, Scer\GAL4^P0206

(Mirzoyan et al., 2023)

egr³/egr³ is a suppressor | partially of gonad | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

egr¹/egr³ is a suppressor of eye-antennal disc | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Katheder et al., 2017)

egr³/egr³ is a suppressor of embryonic/larval hemocyte | larval stage phenotype of scrib¹

(Parisi et al., 2014)

egr³/egr³ is a suppressor of wing disc phenotype of scrib¹

(Parisi et al., 2014)

egr³/egr³ is a suppressor of wing disc phenotype of Scer\GAL4^dpp.PU, Vha44^UAS.cPa

(Petzoldt et al., 2013)

Other

Statement

Reference

egr¹/egr³, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Khoo et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Injecting synthetic Defensin protein into egr³, dlg1^A40.2 larvae re-establishes the increased apoptosis observed in dlg1^A40.2 larvae.

(Parvy et al., 2019)

Third instar larval eye-antennal imaginal disc clones homozygous for scrib¹ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU do not induce significant autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells if the full organism is egr¹/egr³ transheterozygous.

(Katheder et al., 2017)

The increased density of circulating hemocytes observed in scrib¹ larvae is suppressed by egr³ homozygosity.

(Parisi et al., 2014)

egr¹/egr³ partially suppresses the cell death observed in eye-antennal disc clones expressing Rok^CAT.Scer\UAS under the control of Scer\GAL4^tub.PU.

The egr¹/egr³ background fully suppresses the increased cell death seen in eye-antennal disc scrib¹/scrib¹ mutant clones, and also leads to overgrowth of these clones.

(Khoo et al., 2013)

egr³/egr³ completely suppresses the overgrowth and cell migration out of the Scer\GAL4^dpp.PU expression domain which is caused by expression of Vha44^Scer\UAS.cPa under the control of Scer\GAL4^dpp.PU in the wing disc.

(Petzoldt et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

604826

egr³/CyO, P{ActGFP}JMR1

Notes on Origin

Discoverer

Separable from: NimC1^del.

(Kodra et al., 2020)

The NimC1^del mutation present on the egr³ chromosome has been removed by outcrossing to produce a line referred to as "egr[3AG]".

(Kodra et al., 2020)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

egr³

(Loudhaief et al., 2023, Mirzoyan et al., 2023, Trombley et al., 2023, de Vreede et al., 2022, Kodra et al., 2020, La Marca et al., 2019, Parvy et al., 2019, Zhu et al., 2019, Bastos et al., 2017, Katheder et al., 2017, Andersen et al., 2015, Parisi et al., 2014, Khoo et al., 2013, Petzoldt et al., 2013, Mabery and Schneider, 2010, Berkey et al., 2009, Geuking et al., 2009, Tortoriello et al., 2009, Bidla et al., 2007)

egr^3AG

(Mirzoyan et al., 2023, Kodra et al., 2020)

eiger³

(Velarde et al., 2021, He et al., 2017, Muzzopappa et al., 2017, Pérez-Garijo et al., 2013, Etchegaray et al., 2012, Geuking et al., 2009)

eiger[3]

(Nakano et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (27)

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