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General Information
Symbol
Dmel\egr1
Species
D. melanogaster
Name
FlyBase ID
FBal0147164
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
eiger1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{GS} element from egrGS9830 causes a deletion that removes the first coding exon of the egr gene.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

egr1 homozygotes show apparently normal L3 male gonads.

egr1/egr3 mutant adult flies exhibit reduced susceptibility to Coxiella burnetii: their post-infection survival rate is significantly increased compared to wild-type controls.

egr1 mutant embryonic ventral nerve cords have no differences in the volume of apoptotic particles, the percentage of apoptotic particles that are not engulfed by phagocytes, the number of phagosomes, or the number of EVE, DAC or CUT expressing neurons, compared to controls; following irradiation, the increase in apoptotic particles and the decrease in the number of DAC expressing neurons occurs to a lesser extent than in controls.

egr1/egr3 transheterozygous flies exhibit severely reduced feeding rates compared to wild-type.

Homozygous flies are resistant to V. cholerae infection compared to controls.

egr1 mutant flies show a slight increased susceptibility to challenge by Staphylococcus aureus or Enterococcus faecalis compared to wild type flies.

Hemolymph clots from egr1 homozygous third instar larvae show much reduced levels of melanization.

When mutant animals are infected by S.typhimurium, the mean time to death is lengthened by 3 days compared to wild-type animals.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Enhancer of
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Third instar larval eye-antennal imaginal disc clones homozygous for scrib1 and expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU do not induce significant autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells if the full organism is egr1/egr3 transheterozygous.

A egr1 mutant background suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

egr1/egr3 partially suppresses the cell death observed in eye-antennal disc clones expressing RokCAT.Scer\UAS under the control of Scer\GAL4tub.PU.

The egr1/egr3 background fully suppresses the increased cell death seen in eye-antennal disc scrib1/scrib1 mutant clones, and also leads to overgrowth of these clones.

In an egr1 mutant background, scrib1 mutant clones in the eye-antennal disc are no longer eliminated, but grow aggressively and develop into tumours. In this background, expression of egrScer\UAS.cIa under the control of Scer\GAL4Act.PU only in the cells surrounding the scrib1 clones reverses the tumour phenotype; the scrib1 clones do not overgrow and are out-competed by the surrounding cells.

scrib1 mutant clones survive in egr1 mutant eye-antennal discs background. Overgrowth of double mutant cells is observed, and tumor development is observed in pupal eye-antennal tissue. scrib1 mutant clones generated in egr1 mutant wing discs also survive, and tumor development is observed in the wing disc.

Tumour formation and animal lethality are both completely rescued by over-expression of egrScer\UAS.cIa under the control of Scer\GAL4Act5C.PI in scrib1, egr1 double mutant clones.

Xenogenetic Interactions
Statement
Reference

One copy of egr1 enhances the reduction in eye size seen in both males and females when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4GMR.PF at either 24[o]C or 29[o]C. An enhancement is also seen in females at 18[o]C, but no difference is observed in males.

Complementation and Rescue Data
Comments

Expression of egrScer\UAS.cIa under the control of Scer\GAL4He.PZ in a egr1 homozygous mutant background restores melanization levels in hemolymph clots to above wild-type levels.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (24)