FlyBase Allele Report: Dmel\egr[1]

General Information

Symbol

Dmel\egr¹

Species

D. melanogaster

Name

FlyBase ID

FBal0147164

Feature type

allele

Associated gene

Dmel\egr

Associated Insertion(s)

Carried in Construct

Also Known As

eiger¹, egr^1AG

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Igaki et al., 2002)

Progenitor genotype

egr^GS9830

(Igaki et al., 2002)

Cytology

Description

Imprecise excision of the P{GS} element from egr^GS9830 causes a deletion that removes the first coding exon of the egr gene.

(Igaki et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of carcinoma

CEA with scrib¹

(Igaki et al., 2009)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by scrib¹

(Ohsawa et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

egr¹ homozygous retinas exhibit accumulation of lipid droplets in 1-day-old flies and retinal degeneration in 2-weeks-old flies when compared to controls.

(Muliyil et al., 2020)

egr¹ homozygotes show apparently normal L3 male gonads.

(La Marca et al., 2019)

egr¹/egr³ mutant adult flies exhibit reduced susceptibility to Coxiella burnetii: their post-infection survival rate is significantly increased compared to wild-type controls.

(Bastos et al., 2017)

egr¹ mutant embryonic ventral nerve cords have no differences in the volume of apoptotic particles, the percentage of apoptotic particles that are not engulfed by phagocytes, the number of phagosomes, or the number of EVE, DAC or CUT expressing neurons, compared to controls; following irradiation, the increase in apoptotic particles and the decrease in the number of DAC expressing neurons occurs to a lesser extent than in controls.

(Shklover et al., 2015)

egr¹/egr³ transheterozygous flies exhibit severely reduced feeding rates compared to wild-type.

(Mabery and Schneider, 2010)

Homozygous flies are resistant to V. cholerae infection compared to controls.

(Berkey et al., 2009)

egr¹ mutant flies show a slight increased susceptibility to challenge by Staphylococcus aureus or Enterococcus faecalis compared to wild type flies.

(Geuking et al., 2009)

Hemolymph clots from egr¹ homozygous third instar larvae show much reduced levels of melanization.

(Bidla et al., 2007)

When mutant animals are infected by S.typhimurium, the mean time to death is lengthened by 3 days compared to wild-type animals.

(Brandt et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

egr¹, scrib¹ has hyperplasia | somatic clone | pupal stage phenotype, suppressible by egr^UAS.cIa/Scer\GAL4^Act5C.PI

(Igaki et al., 2009)

egr¹, scrib¹ has lethal | somatic clone | pupal stage phenotype, suppressible by egr^UAS.cIa/Scer\GAL4^Act5C.PI

(Igaki et al., 2009)

Enhancer of

Statement

Reference

egr¹/egr[+] is an enhancer of visible | adult stage phenotype of HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

egr¹/egr[+] is an enhancer of abnormal size | adult stage phenotype of HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

NOT Enhancer of

Statement

Reference

egr¹/egr¹ is a non-enhancer of increased cell death | embryonic stage phenotype of Scer\GAL4^elav.PU, rpr^UAS.cUa

(Shklover et al., 2015)

Suppressor of

Statement

Reference

egr¹/egr[+] is a suppressor | partially of increased cell death | larval stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

egr¹/egr[+] is a suppressor | partially of visible | adult stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

egr¹/egr[+] is a suppressor | partially of decreased size | adult stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

egr¹/egr¹ is a suppressor | partially of abnormal size | recessive | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

egr¹/egr³ is a suppressor of neoplasia phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹

(Andersen et al., 2015)

egr¹/egr¹ is a suppressor of increased cell death | embryonic stage phenotype of Scer\GAL4^elav.PU, hid^UAS.cUa

(Shklover et al., 2015)

egr¹/egr¹ is a suppressor of decreased cell number | embryonic stage phenotype of Scer\GAL4^elav.PU, hid^UAS.cUa

(Shklover et al., 2015)

egr¹/egr¹ is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^elav.PU, hid^UAS.cUa

(Shklover et al., 2015)

egr¹ is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

egr¹/egr³ is a suppressor | partially of increased cell death | somatic clone | third instar larval stage phenotype of Rok^CAT.UAS, Scer\GAL4^Tub.PU

(Khoo et al., 2013)

egr¹/egr³ is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of scrib¹

(Khoo et al., 2013)

egr¹ is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of scrib¹

(Igaki et al., 2009)

NOT Suppressor of

Statement

Reference

egr¹/egr¹ is a non-suppressor of neoplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689

(Muzzopappa et al., 2017)

egr¹/egr¹ is a non-suppressor of neoplasia | larval stage phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh.PU, rod^GD8768

(Muzzopappa et al., 2017)

egr¹/egr³ is a non-suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, Syx7^GD2767

(Andersen et al., 2015)

egr¹/egr¹ is a non-suppressor of increased cell death | embryonic stage phenotype of Scer\GAL4^elav.PU, rpr^UAS.cUa

(Shklover et al., 2015)

Other

Statement

Reference

egr¹, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Igaki et al., 2009)

egr¹, scrib¹ has hyperplasia | somatic clone | pupal stage phenotype

(Igaki et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

egr¹/egr[+] is an enhancer of eye phenotype of HAdV-C\E4orf4^UAS.cPa, Scer\GAL4^GMR.PF

(Pechkovsky et al., 2013)

NOT Enhancer of

Statement

Reference

egr¹/egr¹ is a non-enhancer of larval ventral nerve cord | embryonic stage phenotype of Scer\GAL4^elav.PU, rpr^UAS.cUa

(Shklover et al., 2015)

Suppressor of

Statement

Reference

egr¹/egr[+] is a suppressor of embryonic/larval fat body | larval stage phenotype of Noc1^JF02014, Scer\GAL4^P0206

(Mirzoyan et al., 2023)

egr¹/egr[+] is a suppressor | partially of wing phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

egr¹/egr[+] is a suppressor | partially of wing disc | larval stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

egr¹/egr¹ is a suppressor | partially of gonad | male | third instar larval stage phenotype of Strip^jam

(La Marca et al., 2019)

egr¹/egr³ is a suppressor of eye-antennal disc | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Katheder et al., 2017)

egr¹/egr¹ is a suppressor of neuron | embryonic stage phenotype of Scer\GAL4^elav.PU, hid^UAS.cUa

(Shklover et al., 2015)

egr¹/egr¹ is a suppressor of larval ventral nerve cord | embryonic stage phenotype of Scer\GAL4^elav.PU, hid^UAS.cUa

(Shklover et al., 2015)

egr¹ is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

egr¹ is a suppressor of eye-antennal disc | somatic clone | third instar larval stage phenotype of scrib¹

(Igaki et al., 2009)

egr¹ is a suppressor of wing disc | somatic clone | third instar larval stage phenotype of scrib¹

(Igaki et al., 2009)

NOT Suppressor of

Statement

Reference

egr¹/egr¹ is a non-suppressor of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689

(Muzzopappa et al., 2017)

egr¹/egr¹ is a non-suppressor of wing disc phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh.PU, rod^GD8768

(Muzzopappa et al., 2017)

egr¹/egr¹ is a non-suppressor of larval ventral nerve cord | embryonic stage phenotype of Scer\GAL4^elav.PU, rpr^UAS.cUa

(Shklover et al., 2015)

Other

Statement

Reference

egr¹/egr³, scrib¹ has eye-antennal disc | somatic clone | third instar larval stage phenotype

(Khoo et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Third instar larval eye-antennal imaginal disc clones homozygous for scrib¹ and expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU do not induce significant autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells if the full organism is egr¹/egr³ transheterozygous.

(Katheder et al., 2017)

A egr¹ mutant background suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

(Chabu and Xu, 2014)

egr¹/egr³ partially suppresses the cell death observed in eye-antennal disc clones expressing Rok^CAT.Scer\UAS under the control of Scer\GAL4^tub.PU.

The egr¹/egr³ background fully suppresses the increased cell death seen in eye-antennal disc scrib¹/scrib¹ mutant clones, and also leads to overgrowth of these clones.

(Khoo et al., 2013)

In an egr¹ mutant background, scrib¹ mutant clones in the eye-antennal disc are no longer eliminated, but grow aggressively and develop into tumours. In this background, expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^Act.PU only in the cells surrounding the scrib¹ clones reverses the tumour phenotype; the scrib¹ clones do not overgrow and are out-competed by the surrounding cells.

(Ohsawa et al., 2011)

scrib¹ mutant clones survive in egr¹ mutant eye-antennal discs background. Overgrowth of double mutant cells is observed, and tumor development is observed in pupal eye-antennal tissue. scrib¹ mutant clones generated in egr¹ mutant wing discs also survive, and tumor development is observed in the wing disc.

Tumour formation and animal lethality are both completely rescued by over-expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^Act5C.PI in scrib¹, egr¹ double mutant clones.

(Igaki et al., 2009)

Xenogenetic Interactions

Statement

Reference

One copy of egr¹ enhances the reduction in eye size seen in both males and females when Zzzz\E4orf4^Scer\UAS.cPa is expressed under the control of Scer\GAL4^GMR.PF at either 24[o]C or 29[o]C. An enhancement is also seen in females at 18[o]C, but no difference is observed in males.

(Pechkovsky et al., 2013)

Complementation and Rescue Data

Rescued by

egr¹ is rescued by egr^UAS.cIa/Scer\GAL4^He.PZ

(Bidla et al., 2007)

Comments

Expression of egr^Scer\UAS.cIa under the control of Scer\GAL4^He.PZ in a egr¹ homozygous mutant background restores melanization levels in hemolymph clots to above wild-type levels.

(Bidla et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

604825

w^*; egr¹/CyO, P{Dfd-EYFP.w^BmC}2

Notes on Origin

Discoverer

Separable from: NimC1^del.

(Kodra et al., 2020)

The NimC1^del mutation present on the egr¹ chromosome has been removed by outcrossing to produce a line referred to as "egr[1AG]".

(Kodra et al., 2020)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

egr¹

(Mirzoyan et al., 2023, de Vreede et al., 2022, Wada et al., 2021, Kodra et al., 2020, Muliyil et al., 2020, La Marca et al., 2019, Zhu et al., 2019, Poernbacher and Vincent, 2018, Bastos et al., 2017, Katheder et al., 2017, Andersen et al., 2015, Parisi et al., 2014, Khoo et al., 2013, Ohsawa et al., 2011, Mabery and Schneider, 2010, Berkey et al., 2009, Geuking et al., 2009, Igaki et al., 2009, Bidla et al., 2007)

egr^1AG

(Mirzoyan et al., 2023, Kodra et al., 2020)

eiger

(Pechkovsky et al., 2013)

eiger¹

(Velarde et al., 2021, He et al., 2017, Kenmoku et al., 2017, Muzzopappa et al., 2017, Shklover et al., 2015, Pérez-Garijo et al., 2013, Pallavi et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (30)

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