FB2025_01 , released February 20, 2025
Allele: Dmel\c(2)MZ3780
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General Information
Symbol
Dmel\c(2)MZ3780
Species
D. melanogaster
Name
FlyBase ID
FBal0147242
Feature type
allele
Associated gene
Dmel\c(2)M
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Manheim and McKim, 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: V94E.

(Manheim and McKim, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,303,711..16,303,711 [+]
Nucleotide change:

T16303711A

Amino acid change:

V94E | c(2)M-PA

Reported amino acid change:

V94E

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Manheim and McKim, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes exhibit a high rate on non-disjunction (13.4% X chromosome non-disjunction) and a reduced number of crossovers, with the number of crossovers per physical distance diminishing as the region approaches the centromere.

      (Manheim and McKim, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      c(2)MEP2115

      (Manheim and McKim, 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phenotypic analysis (non-disjunction) provides an allelic series: c(2)MEP2115 > c(2)MZ0810 > c(2)MZ3780.

      (Manheim and McKim, 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      c(2)MZ3780
      Name Synonyms
      Secondary FlyBase IDs
        References (1)